Page last updated: 2024-12-08
solavetivone
Description
solavetivone: from Solanum indicum (Solanaceae); structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
solavetivone : A cyclic ketone derived from spiro[4.5]dec-6-en-8-one by substitution of hydrogens by methyl groups at positions 6 and 10, and by an isopropenyl group at position 2 (the (2R,5S,10R)-diastereoisomer). [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|
| Solanum | genus | A plant genus of the family SOLANACEAE. Members contain SOLANACEOUS ALKALOIDS. Some species in this genus are called deadly nightshade which is also a common name for ATROPA BELLADONNA.[MeSH] | Solanaceae | A plant family of the order SOLANALES, class MAGNOLIOPSIDA. Among the most noted are POTATOES; TOMATOES; CAPSICUM (green and red peppers); TOBACCO; and BELLADONNA.[MeSH] |
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 442399 |
| CHEMBL ID | 465907 |
| CHEBI ID | 9192 |
| SCHEMBL ID | 707134 |
| MeSH ID | M0403807 |
Synonyms (21)
| Synonym |
|---|
| 54878-25-0 |
| C09737 |
| solavetivone |
| ()-(2r,5s,10r)-2-isopropenyl-6,10-dimethylspiro[4.5]dec-6-en-8-one |
| (2r,5s,10r)-6,10-dimethyl-2-(prop-1-en-2-yl)spiro[4.5]dec-6-en-8-one |
| katahdinone |
| ()-solavetivone |
| (-)-solavetivone |
| chebi:9192 , |
| CHEMBL465907 |
| (-)-(2r,5s,10r)-2-isopropenyl-6,10-dimethylspiro[4.5]dec-6-en-8-one |
| (3r,5s,6r)-6,10-dimethyl-3-prop-1-en-2-ylspiro[4.5]dec-9-en-8-one |
| spiro(4.5)dec-6-en-8-one, 6,10-dimethyl-2-(1-methylethenyl)-, (2r,5s,10r)- |
| (2r,5s,10r)-2-isopropenyl-6,10-dimethylspiro(4,5)-dec-6-en-8-one |
| hs8o8a7rez , |
| unii-hs8o8a7rez |
| SCHEMBL707134 |
| (2r,5s,10r)-6,10-dimethyl-2-(1-methylethenyl)spiro(4.5)dec-6-en-8-one |
| Q27108304 |
| DTXSID00970214 |
| 6,10-dimethyl-2-(prop-1-en-2-yl)spiro[4.5]dec-6-en-8-one |
Research Excerpts
Effects
Roles (2)
| Role | Description |
|---|
| phytoalexin | A toxin made by a plant that acts against an organism attacking it. |
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Drug Classes (3)
| Class | Description |
|---|
| spiro compound | A compound having one atom as the only common member of two rings. |
| sesquiterpenoid | Any terpenoid derived from a sesquiterpene. The term includes compounds in which the C15 skeleton of the parent sesquiterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups). |
| cyclic ketone | |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Bioassays (3)
| Assay ID | Title | Year | Journal | Article |
|---|
| AID403529 | Antibacterial activity against Staphylococcus aureus after 2 days by agar plate dilution method | 1998 | Journal of natural products, Dec, Volume: 61, Issue:12
| Phytoalexins from hairy roots of Hyoscyamus albus treated with methyl jasmonate. |
| AID403530 | Antibacterial activity against Bacillus subtilis after 2 days by agar plate dilution method | 1998 | Journal of natural products, Dec, Volume: 61, Issue:12
| Phytoalexins from hairy roots of Hyoscyamus albus treated with methyl jasmonate. |
| AID357930 | Cytotoxicity against human OVCAR-3 cells | 2001 | Journal of natural products, Sep, Volume: 64, Issue:9
| Cytotoxic and novel compounds from Solanum indicum. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (6)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 23.24
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 23.24 (24.57) | | Research Supply Index | 2.08 (2.92) | | Research Growth Index | 4.73 (4.65) | | Search Engine Demand Index | 21.17 (26.88) | | Search Engine Supply Index | 2.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |