prolyl-glycyl-proline has been researched along with Brain-Ischemia* in 3 studies
3 other study(ies) available for prolyl-glycyl-proline and Brain-Ischemia
| Article | Year |
|---|---|
Semax, an analog of ACTH
Brain stroke continues to claim the lives of million people every year. To build the effective strategies for stroke treatment it is necessary to understand the neuroprotective mechanisms that are able to prevent the ischemic injury. Consisting of the ACTH Topics: Adrenocorticotropic Hormone; Animals; Antigen Presentation; Brain Ischemia; Disease Models, Animal; Gene Expression Profiling; Genes, Immunoglobulin Heavy Chain; Immunoglobulin Heavy Chains; Male; Middle Cerebral Artery; Neuroprotective Agents; Oligopeptides; Peptide Fragments; Proline; Rats; Rats, Wistar; Stress, Physiological; Transcriptome | 2017 |
The effect of Semax and its C-end peptide PGP on the morphology and proliferative activity of rat brain cells during experimental ischemia: a pilot study.
The neuropeptide preparation Semax (Met-Glu-His-Phe-Pro-Gly-Pro) has been employed successfully in clinical practice for treating patients with severe brain blood circulation disorders. In spite of numerous studies, many aspects of the therapeutic effects of this preparation remain unknown. In this context, the effects of Semax and its C-end tripeptide PGP on the functional morphology of nervous tissue cells were studied in the normal rat brain and in a model of incomplete global rat brain ischemia. In control animals, both peptides activated the capillary network and caused similar morphological changes to neurons and the neuropil regions. We show here for the first time at the histological level that Semax and PGP increased proliferation of the neuroglia, blood vessel endothelium, and progenitor cells in the subventricular zone. In these experimental conditions, only Semax abated the manifestation of ischemic damage to the nervous tissue. This was probably attributable to a decrease in vascular stasis symptoms as well as the trophic effect of the peptide. Topics: Adrenocorticotropic Hormone; Animals; Brain; Brain Ischemia; Cell Proliferation; Humans; Male; Neuroprotective Agents; Oligopeptides; Peptide Fragments; Pilot Projects; Proline; Rats; Rats, Wistar | 2011 |
C-terminal Pro-Gly-Pro tripeptide in contrast to full-length neuropeptide semax exhibits no neuroprotective effect in experimental cerebral ischemia.
The C-terminal fragment Pro-Gly-Pro of semax does not modulate the development of symptoms of neurological deficiency and mortality in rats with incomplete global cerebral ischemia. Hence, previously revealed neuroprotective effects of semax are mainly determined by corticotropin ACTH4-7 fragment. Topics: Animals; Brain Ischemia; Neuroprotective Agents; Oligopeptides; Proline; Rats | 2005 |