prolyl-glycyl-proline has been researched along with Gastritis* in 1 studies
1 other study(ies) available for prolyl-glycyl-proline and Gastritis
| Article | Year |
|---|---|
Effects of Glyprolines on DNA Synthesis and Free Radical Oxidation in Mouse Gastric Mucosa Under Physiological Conditions and During Therapy with Oral Non-Steroid Anti-Inflammatory Drugs.
Studies by (3)H-thymidin autoradiography showed that injections of Pro-Gly-Pro and Arg-Gly-Pro peptides caused no changes in the DNA synthesis processes in the gastric mucosa. Both peptides induced a reduction of free radical oxidation activity, which was shown by chemiluminescence. Indomethacin induced lesions in the gastric mucosa, triggered oxidative stress, and reduced proliferative activity. Injection of Pro-Gly-Pro peptide before indomethacin corrected disorders in oxidative status and normalized DNA synthesis. Preinjection of Arg-Gly-Pro led to enlargement (by 4.6 times) of the focus of lesions in animals treated by indomethacin and augmented oxidative stress. Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; DNA Replication; Drug Evaluation, Preclinical; Free Radical Scavengers; Free Radicals; Gastric Mucosa; Gastritis; Indomethacin; Male; Mice; Oligopeptides; Oxidation-Reduction; Oxidative Stress; Proline | 2015 |