Compounds > dehydrolysine

Page last updated: 2024-11-12

dehydrolysine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID Source	ID
PubMed CID	10219500
CHEMBL ID	1241436
SCHEMBL ID	2266509
SCHEMBL ID	2266512
MeSH ID	M0042691

Synonyms (12)

Synonym
(e)-2,6-diaminohex-4-enoic acid
4,5-trans-dehydrolysine
dehydrolysine
AKOS006271649
CHEMBL1241436
5-hexenoic acid, 2,6-diamino-, (e)-(+-)-
34069-68-6
trans-4,5-dehydrolysine
SCHEMBL2266509
SCHEMBL2266512
4-hexenoicacid,2,6-diamino-,(4e)-
(e)-2,6-diaminohex-4-enoicacid

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay ID	Title	Year	Journal	Article
AID1204889	Binding affinity to lysC riboswitch in Bacillus subtilis	2015	Journal of medicinal chemistry, Apr-23, Volume: 58, Issue:8	(Dis)similar Analogues of Riboswitch Metabolites as Antibacterial Lead Compounds.
AID513354	Binding affinity to lysine riboswitch 179 lysc of Bacillus subtilis 168 M2 harboring adenosine deletion within 95 to 97 sequence in loop E of P2 motif	2007	Nature chemical biology, Jan, Volume: 3, Issue:1	Antibacterial lysine analogs that target lysine riboswitches.
AID513348	Antibacterial activity against Bacillus subtilis 168 M1 harboring G163A mutation in P4 motif after 24 hrs by CLSI method	2007	Nature chemical biology, Jan, Volume: 3, Issue:1	Antibacterial lysine analogs that target lysine riboswitches.
AID513352	Binding affinity to Bacillus subtilis 168 1A1 lysine riboswitch 179 lysc	2007	Nature chemical biology, Jan, Volume: 3, Issue:1	Antibacterial lysine analogs that target lysine riboswitches.
AID513349	Antibacterial activity against Bacillus subtilis 168 M2 harboring adenosine deletion within 95 to 97 sequence in loop E of P2 motif after 24 hrs by CLSI method	2007	Nature chemical biology, Jan, Volume: 3, Issue:1	Antibacterial lysine analogs that target lysine riboswitches.
AID513343	Binding affinity to Bacillus subtilis 168 1A1 lysine riboswitch 179 lysc by in-line probing assay	2007	Nature chemical biology, Jan, Volume: 3, Issue:1	Antibacterial lysine analogs that target lysine riboswitches.
AID513346	Inhibition of wild-type Bacillus subtilis 168 1A1 lysine riboswitch 179 lysc assessed as reduction of beta-galactosidase activity at 5 mM after 3 hrs by lacZ reporter gene assay	2007	Nature chemical biology, Jan, Volume: 3, Issue:1	Antibacterial lysine analogs that target lysine riboswitches.
AID513344	Antibacterial activity against Bacillus subtilis 168 1A1 at 100 uM after 24 hrs by by CLSI method	2007	Nature chemical biology, Jan, Volume: 3, Issue:1	Antibacterial lysine analogs that target lysine riboswitches.
AID513345	Antibacterial activity against Bacillus subtilis 1A40 at 1 mM after 3 hrs by CLSI method	2007	Nature chemical biology, Jan, Volume: 3, Issue:1	Antibacterial lysine analogs that target lysine riboswitches.
AID513351	Inhibition of lysine riboswitch 179 lysc in Bacillus subtilis 168 M2 harboring adenosine deletion within 95 to 97 sequence in loop E of P2 motif assessed as reduction of beta-galactosidase activity at 5 mM after 3 hrs by lacZ reporter gene assay	2007	Nature chemical biology, Jan, Volume: 3, Issue:1	Antibacterial lysine analogs that target lysine riboswitches.
AID513350	Inhibition of lysine riboswitch 179 lysc in Bacillus subtilis 168 M1 harboring G163A mutation in P4 motif assessed as reduction of beta-galactosidase activity at 5 mM after 3 hrs by lacZ reporter gene assay	2007	Nature chemical biology, Jan, Volume: 3, Issue:1	Antibacterial lysine analogs that target lysine riboswitches.
AID513357	Antibacterial activity against Bacillus subtilis 168 1A1 after 24 hrs by CLSI method	2007	Nature chemical biology, Jan, Volume: 3, Issue:1	Antibacterial lysine analogs that target lysine riboswitches.
AID513353	Binding affinity to lysine riboswitch 179 lysc of Bacillus subtilis 168 M1 harboring G163A mutation in P4 motif	2007	Nature chemical biology, Jan, Volume: 3, Issue:1	Antibacterial lysine analogs that target lysine riboswitches.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (60.00)	29.6817
2010's	2 (40.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.87

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.87 (24.57)
Research Supply Index	1.79 (2.92)
Research Growth Index	4.66 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.87)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (20.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	4 (80.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
2-aminoadipic acid 2-Aminoadipic Acid: A metabolite in the principal biochemical pathway of lysine. It antagonizes neuroexcitatory activity modulated by the glutamate receptor, N-METHYL-D-ASPARTATE; (NMDA).. 2-aminoadipic acid : An alpha-amino acid that is adipic acid bearing a single amino substituent at position 2. An intermediate in the formation of lysine.	2.15	1	0	amino dicarboxylic acid; dicarboxylic fatty acid; non-proteinogenic alpha-amino acid	Caenorhabditis elegans metabolite; mammalian metabolite
dithionite Dithionite: Dithionite. The dithionous acid ion and its salts.	2	1	0	sulfur oxide; sulfur oxoanion
lysine Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.	9.24	5	0	aspartate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; lysine; organic molecular entity; proteinogenic amino acid	algal metabolite; anticonvulsant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
homoarginine L-homoarginine : An L-lysine derivative that is the L-enantiomer of homoarginine.	3.57	2	0	homoarginine; L-lysine derivative; non-proteinogenic L-alpha-amino acid	biomarker; EC 3.1.3.1 (alkaline phosphatase) inhibitor; human metabolite; rat metabolite; xenobiotic metabolite
selenomethionine [no description available]	2	1	0	selenoamino acid; selenomethionines	plant metabolite
deuterium Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.	2	1	0	dihydrogen
n-epsilon-acetyllysine N(6)-acetyl-L-lysine : An N(6)-acyl-L-lysine where the N(6)-acyl group is specified as acetyl.	2.03	1	0	acetyl-L-lysine; amino acid zwitterion; N(6)-acyl-L-lysine	human metabolite
n(alpha)-acetyllysine N(alpha)-acetyllysine: RN given refers to (L)-isomer. acetyl-L-lysine : An N-acetyl-L-amino acid that is the N-acetyl derivative of L-lysine.. N(2)-acetyl-L-lysine : An acetyl-L-lysine where the acetyl group is located at the N(2)-posiiton.	2.03	1	0	acetyl-L-lysine; amino acid zwitterion	human metabolite
s-2-aminoethyl cysteine S-2-aminoethyl cysteine: inhibits protein synthesis in mammalian cells; RN given refers to parent cpd; structure. L-thialysine : A cysteine derivative that is the S-(2-aminoethyl) analogue of L-cysteine; reported to have cytotoxic effects.	3.57	2	0	L-cysteine thioether; non-proteinogenic L-alpha-amino acid	EC 5.4.3.2 (lysine 2,3-aminomutase) inhibitor; metabolite; protein synthesis inhibitor
2-amino-n(6)-hydroxyadenine 2-amino-N(6)-hydroxyadenine: mutagen & bacterial growth inhibitor; structure in first source. 2-amino-6-hydroxyaminopurine : A 2,6-diaminopurine that is the N(6)-hydroxy derivative of 2,6-diamino-3H-purine.	3.21	1	0	2,6-diaminopurines; hydroxylamines; nucleobase analogue	mutagen; teratogenic agent
i-677 4-oxalysine: from Streptomyces reseoviridofuscus; RN given refers to cpd without isomeric designation. O-(2-aminoethyl)-L-serine : An L-alpha-amino acid that is L-serine in which the hydroxy group at position 3 is converted to the corresponding 2-aminoethyl ether. An antimetabolic antibiotic obtained from Streptomyces reseoviridofuscus.	3.57	2	0	L-serine derivative; non-proteinogenic L-alpha-amino acid	antimetabolite; antimicrobial agent; antineoplastic agent; metabolite
allysine L-allysine : An optically active form of allysine having L-configuration.	2.15	1	0	allysine; amino acid zwitterion; aminoadipate semialdehyde; non-proteinogenic L-alpha-amino acid	human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
kynurenine L-kynurenine : A kynurenine that has L configuration.	2.03	1	0	amino acid zwitterion; kynurenine; non-proteinogenic L-alpha-amino acid	human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
5'-deoxyadenosine 5'-deoxyadenosine: main heading DEOXYADENOSINE refers to the 3' cpd. 5'-deoxyadenosine : A 5'-deoxyribonucleoside compound having adenosine as the nucleobase.	2	1	0	5'-deoxyribonucleoside; adenosines	Escherichia coli metabolite; human metabolite; mouse metabolite
trimethyllysine trimethyllysine: stimulates growth of tumor cells; RN given refers to (S)-isomer	2.03	1	0	alpha-amino-acid cation	human metabolite; mouse metabolite
n(6)-(1-iminoethyl)lysine N(6)-acetimidoyl-L-lysine : An L-lysine derivative that is L-lysine in which one of the hydrogens attached to N(6) is substituted by an acetimidoyl group	2.03	1	0	L-lysine derivative; non-proteinogenic L-alpha-amino acid
s-adenosylmethionine (R)-S-adenosyl-L-methionine : An S-adenosyl-L-methionine that has R-configuration.. S-adenosyl-L-methionine zwitterion : A zwitterionic tautomer of S-adenosyl-L-methionine arising from shift of the proton from the carboxy group to the amino group.. (R)-S-adenosyl-L-methionine zwitterion : An S-adenosyl-L-methionine zwitterion that has R-configuration; major species at pH 7.3.. (S)-S-adenosyl-L-methionine zwitterion : An S-adenosyl-L-methionine zwitterion that has S-configuration; major species at pH 7.3.. S-adenosyl-L-methionine : A sulfonium compound that is the S-adenosyl derivative of L-methionine. It is an intermediate in the metabolic pathway of methionine.	2	1	0	organic cation; sulfonium compound	coenzyme; cofactor; human metabolite; micronutrient; Mycoplasma genitalium metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
guanine [no description available]	3.21	1	0	2-aminopurines; oxopurine; purine nucleobase	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
6-hydroxy-2,4,5-triaminopyrimidine 6-hydroxy-2,4,5-triaminopyrimidine: pyrimidine moiety of pterins; RN given refers to parent cpd; structure. 2,5,6-triamino-4-hydroxypyrimidine : A member of the class of aminopyrimidines that is 2,5,6-triaminopyrimidine carrying an additional hydroxy substituent at position 4.	3.21	1	0	aminopyrimidine; hydroxypyrimidine	antioxidant; chromophore

Condition	Indicated	Relationship Strength	Studies	Trials
Bacterial Disease [description not available]	0	3.03	1	0
Bacterial Infections Infections by bacteria, general or unspecified.	0	3.03	1	0