n(6)-(1-iminoethyl)lysine and Chronic-Disease

n(6)-(1-iminoethyl)lysine has been researched along with Chronic-Disease* in 1 studies

Other Studies

1 other study(ies) available for n(6)-(1-iminoethyl)lysine and Chronic-Disease

Article	Year
1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo. Journal of medicinal chemistry, 2003, Mar-13, Volume: 46, Issue:6 The discovery of a novel class of nitric oxide synthase (NOS) inhibitors, 2-substituted 1,2-dihydro-4-quinazolinamines, and the related 4'-aminospiro[piperidine-4,2'(1'H)-quinazolin]-4'-amines is described. Members of both series exhibit nanomolar potency and high selectivity for the inducible isoform of the enzyme (i-NOS) relative to the constitutive isoforms in vitro. Efficacy in acute and chronic animal models of inflammatory disease following oral administration has also been demonstrated using these compounds. Topics: Acute Disease; Administration, Oral; Amines; Animals; Arthritis, Experimental; Cell Line; Chronic Disease; Enzyme Inhibitors; Injections, Intravenous; Isoenzymes; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Quinazolines; Rats; Spiro Compounds; Structure-Activity Relationship	2003

Article

Year

1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo.

Journal of medicinal chemistry, 2003, Mar-13, Volume: 46, Issue:6

The discovery of a novel class of nitric oxide synthase (NOS) inhibitors, 2-substituted 1,2-dihydro-4-quinazolinamines, and the related 4'-aminospiro[piperidine-4,2'(1'H)-quinazolin]-4'-amines is described. Members of both series exhibit nanomolar potency and high selectivity for the inducible isoform of the enzyme (i-NOS) relative to the constitutive isoforms in vitro. Efficacy in acute and chronic animal models of inflammatory disease following oral administration has also been demonstrated using these compounds.

Topics: Acute Disease; Administration, Oral; Amines; Animals; Arthritis, Experimental; Cell Line; Chronic Disease; Enzyme Inhibitors; Injections, Intravenous; Isoenzymes; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Quinazolines; Rats; Spiro Compounds; Structure-Activity Relationship

2003