Page last updated: 2024-11-12

(S)-Isosclerone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID10442251
CHEMBL ID448359
CHEBI ID192112

Synonyms (21)

Synonym
NCGC00180322-01
ACON1_001617
4,8-dihydroxy-3,4-dihydro-2h-naphthalen-1-one
BRD-A75320967-001-01-8
CHEMBL448359
4,8-dihydroxy-1-tetralone
(s)-isosclerone
62332-73-4
CHEBI:192112
1(2h)-naphthalenone, 3,4-dihydro-4,8-dihydroxy-
AKOS022639864
4,8-dihydroxy-1,2,3,4-tetrahydronaphthalen-1-one
(4s)-4,8-dihydroxy-alpha-tetralone
(4rs)-4,8-dihydroxy-3,4-dihydronaphthalen-1(2h)-one
bdbm50597760
AU5N5H7K3C ,
unii-au5n5h7k3c
4,8-dihydroxytetralin-1-one
(+/-)-isosclerone
isosclerone, (+/-)-
3,4-dihydro-4,8-dihydroxy-1(2h)-naphthalenone
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
tetralinsCompounds containing a tetralin skeleton.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (19)

Assay IDTitleYearJournalArticle
AID1082818Antifungal activity against Colletotrichum gloeosporioides at 28 degC after 48 hr microbroth dilution method2012Journal of agricultural and food chemistry, Apr-04, Volume: 60, Issue:13
Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
AID1918888Induction of adipogenesis in differentiated human BMMSC cells assessed as increase in adiponectin level at 30 uM in presence of IDX by ELISA2022Journal of natural products, 12-23, Volume: 85, Issue:12
Discovery of Pan-peroxisome Proliferator-Activated Receptor Modulators from an Endolichenic Fungus,
AID1082820Antifungal activity against Fusarium oxysporum f. sp. niveum at 28 degC after 48 hr microbroth dilution method2012Journal of agricultural and food chemistry, Apr-04, Volume: 60, Issue:13
Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
AID1478517Cytotoxicity against human Ramos cells assessed as decrease in cell viability after 24 hrs by CellTiter-Glo assay2017Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11
Identification of spirobisnaphthalene derivatives with anti-tumor activities from the endophytic fungus Rhytidhysteron rufulum AS21B.
AID377984Antifungal activity against Eurotium repens at 50 ug by agar diffusion test1999Journal of natural products, Jan, Volume: 62, Issue:1
Three new metabolites from marine-derived fungi of the genera coniothyrium and microsphaeropsis
AID1082821Antifungal activity against Fusarium oxysporum f. sp. vasinfectum at 28 degC after 48 hr microbroth dilution method2012Journal of agricultural and food chemistry, Apr-04, Volume: 60, Issue:13
Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
AID405579Nematicidal activity against Bursaphelenchus xylophilus at 200 ug/ml after 48 hrs2008Journal of natural products, Jun, Volume: 71, Issue:6
Ymf 1029A-E, preussomerin analogues from the fresh-water-derived fungus YMF 1.01029.
AID405696Nematicidal activity against Bursaphelenchus xylophilus at 100 ug/ml after 48 hrs2008Journal of natural products, Jun, Volume: 71, Issue:6
Ymf 1029A-E, preussomerin analogues from the fresh-water-derived fungus YMF 1.01029.
AID1082822Antifungal activity against Fusarium graminearum at 28 degC after 48 hr microbroth dilution method2012Journal of agricultural and food chemistry, Apr-04, Volume: 60, Issue:13
Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
AID1082823Toxicity in Artemia salina (brine shrimp) at 28 degC after 48 hr2012Journal of agricultural and food chemistry, Apr-04, Volume: 60, Issue:13
Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
AID377985Antifungal activity against Ustilago violacea at 50 ug by agar diffusion test1999Journal of natural products, Jan, Volume: 62, Issue:1
Three new metabolites from marine-derived fungi of the genera coniothyrium and microsphaeropsis
AID1478518Cytotoxicity against human NCI-H1975 cells assessed as decrease in cell viability after 72 hrs by CellTiter-Glo assay2017Bioorganic & medicinal chemistry, 06-01, Volume: 25, Issue:11
Identification of spirobisnaphthalene derivatives with anti-tumor activities from the endophytic fungus Rhytidhysteron rufulum AS21B.
AID405578Nematicidal activity against Bursaphelenchus xylophilus at 200 ug/ml after 24 hrs2008Journal of natural products, Jun, Volume: 71, Issue:6
Ymf 1029A-E, preussomerin analogues from the fresh-water-derived fungus YMF 1.01029.
AID1082815Antifungal activity against Botryotinia fuckeliana at 28 degC after 48 hr microbroth dilution method2012Journal of agricultural and food chemistry, Apr-04, Volume: 60, Issue:13
Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
AID405580Nematicidal activity against Bursaphelenchus xylophilus at 100 ug/ml after 24 hrs2008Journal of natural products, Jun, Volume: 71, Issue:6
Ymf 1029A-E, preussomerin analogues from the fresh-water-derived fungus YMF 1.01029.
AID1082816Antifungal activity against Alternaria solani at 28 degC after 48 hr microbroth dilution method2012Journal of agricultural and food chemistry, Apr-04, Volume: 60, Issue:13
Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
AID1082819Antifungal activity against Fusarium solani at 28 degC after 48 hr microbroth dilution method2012Journal of agricultural and food chemistry, Apr-04, Volume: 60, Issue:13
Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
AID1882002Inhibition of AChE (unknown origin) using acetylcholine as substrate preincubated for 15 mins by Ellman's method2022European journal of medicinal chemistry, Jan-05, Volume: 227Research progress in pharmacological activities and structure-activity relationships of tetralone scaffolds as pharmacophore and fluorescent skeleton.
AID1082817Antifungal activity against Alternaria alternata at 28 degC after 48 hr microbroth dilution method2012Journal of agricultural and food chemistry, Apr-04, Volume: 60, Issue:13
Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's1 (16.67)29.6817
2010's2 (33.33)24.3611
2020's2 (33.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.03

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.03 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.97 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.03)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (16.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (83.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]