Compounds > fumiquinazoline f
Page last updated: 2024-11-12

fumiquinazoline f

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

fumiquinazoline F: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

fumiquinazoline F : A fumiquinazoline that consists of pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione bearing a methyl substituent at position 1 and an indol-3-yl group at position 4. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID10089772
CHEMBL ID2229117
CHEBI ID64550
MeSH IDM0490744

Synonyms (9)

Synonym
CHEBI:64550 ,
(1s,4r)-4-(1h-indol-3-ylmethyl)-1-methyl-2h-pyrazino[2,1-b]quinazoline-3,6(1h,4h)-dione
fumiquinazoline f
CHEMBL2229117
(1s,4r)-4-(1h-indol-3-ylmethyl)-1-methyl-2,4-dihydro-1h-pyrazino[2,1-b]quinazoline-3,6-dione
169626-35-1
DTXSID30891847
Q27133342
C22145
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (3)

ClassDescription
pyrazinoquinazolineAny organic heterotricyclic compound that consists of a pyrazine ring ortho-fused to a quinazoline.
fumiquinazolineA group of indole alkaloids biosynthesised using L-tryptophan, L-alanine and anthranilic acid building blocks.
indolesAny compound containing an indole skeleton.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

PathwayProteinsCompounds
fumiquinazoline D biosynthesis515

Bioassays (23)

Assay IDTitleYearJournalArticle
AID1225326Cytotoxicity against human A549 cells2015Journal of natural products, Mar-27, Volume: 78, Issue:3
Alkaloidal metabolites from a marine-derived Aspergillus sp. fungus.
AID1225332Antimicrobial activity against Proteus hauseri incubated for 24 hrs2015Journal of natural products, Mar-27, Volume: 78, Issue:3
Alkaloidal metabolites from a marine-derived Aspergillus sp. fungus.
AID1225335Inhibition of sortase A (unknown origin)2015Journal of natural products, Mar-27, Volume: 78, Issue:3
Alkaloidal metabolites from a marine-derived Aspergillus sp. fungus.
AID1082819Antifungal activity against Fusarium solani at 28 degC after 48 hr microbroth dilution method2012Journal of agricultural and food chemistry, Apr-04, Volume: 60, Issue:13
Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
AID1225331Antimicrobial activity against Salmonella typhimurium incubated for 24 hrs2015Journal of natural products, Mar-27, Volume: 78, Issue:3
Alkaloidal metabolites from a marine-derived Aspergillus sp. fungus.
AID1082821Antifungal activity against Fusarium oxysporum f. sp. vasinfectum at 28 degC after 48 hr microbroth dilution method2012Journal of agricultural and food chemistry, Apr-04, Volume: 60, Issue:13
Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
AID1225336Inhibition of Candida albicans isocitrate lyase assessed as reduction in glyoxylate phenylhydrazone formation using phenylhydrazine and isocitrate incubated for 30 mins by spectrophotometry2015Journal of natural products, Mar-27, Volume: 78, Issue:3
Alkaloidal metabolites from a marine-derived Aspergillus sp. fungus.
AID1082816Antifungal activity against Alternaria solani at 28 degC after 48 hr microbroth dilution method2012Journal of agricultural and food chemistry, Apr-04, Volume: 60, Issue:13
Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
AID1082823Toxicity in Artemia salina (brine shrimp) at 28 degC after 48 hr2012Journal of agricultural and food chemistry, Apr-04, Volume: 60, Issue:13
Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
AID1858673Antibacterial activity against Staphylococcus aureus assessed as bacterial growth inhibition2021European journal of medicinal chemistry, Jan-01, Volume: 209Tryptophan derived natural marine alkaloids and synthetic derivatives as promising antimicrobial agents.
AID1225329Antimicrobial activity against Bacillus subtilis incubated for 24 hrs2015Journal of natural products, Mar-27, Volume: 78, Issue:3
Alkaloidal metabolites from a marine-derived Aspergillus sp. fungus.
AID1082815Antifungal activity against Botryotinia fuckeliana at 28 degC after 48 hr microbroth dilution method2012Journal of agricultural and food chemistry, Apr-04, Volume: 60, Issue:13
Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
AID1082817Antifungal activity against Alternaria alternata at 28 degC after 48 hr microbroth dilution method2012Journal of agricultural and food chemistry, Apr-04, Volume: 60, Issue:13
Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
AID1225333Antimicrobial activity against Escherichia coli incubated for 24 hrs2015Journal of natural products, Mar-27, Volume: 78, Issue:3
Alkaloidal metabolites from a marine-derived Aspergillus sp. fungus.
AID1858675Antibacterial activity against Micrococcus luteus assessed as bacterial growth inhibition2021European journal of medicinal chemistry, Jan-01, Volume: 209Tryptophan derived natural marine alkaloids and synthetic derivatives as promising antimicrobial agents.
AID1225334Inhibition of porcine cerebral cortex Na+/K+ ATPase using 3-O-methylfluorescein phosphate and creatinine phosphate incubated for 30 mins by spectrophotometry2015Journal of natural products, Mar-27, Volume: 78, Issue:3
Alkaloidal metabolites from a marine-derived Aspergillus sp. fungus.
AID1082822Antifungal activity against Fusarium graminearum at 28 degC after 48 hr microbroth dilution method2012Journal of agricultural and food chemistry, Apr-04, Volume: 60, Issue:13
Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
AID1225328Antimicrobial activity against Staphylococcus aureus incubated for 24 hrs2015Journal of natural products, Mar-27, Volume: 78, Issue:3
Alkaloidal metabolites from a marine-derived Aspergillus sp. fungus.
AID1082820Antifungal activity against Fusarium oxysporum f. sp. niveum at 28 degC after 48 hr microbroth dilution method2012Journal of agricultural and food chemistry, Apr-04, Volume: 60, Issue:13
Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
AID1225327Cytotoxicity against human K562 cells2015Journal of natural products, Mar-27, Volume: 78, Issue:3
Alkaloidal metabolites from a marine-derived Aspergillus sp. fungus.
AID1082824Antifeedant activity against Mythimna separata (Oriental armyworm) larvae assessed as antifeedant index by area of the leaf consumed2012Journal of agricultural and food chemistry, Apr-04, Volume: 60, Issue:13
Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
AID1082818Antifungal activity against Colletotrichum gloeosporioides at 28 degC after 48 hr microbroth dilution method2012Journal of agricultural and food chemistry, Apr-04, Volume: 60, Issue:13
Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
AID1225330Antimicrobial activity against Micrococcus luteus incubated for 24 hrs2015Journal of natural products, Mar-27, Volume: 78, Issue:3
Alkaloidal metabolites from a marine-derived Aspergillus sp. fungus.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's4 (66.67)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.78

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.78 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.72 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.78)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (16.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (83.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
uracil
2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder		2.0710pyrimidine nucleobase;
pyrimidone		allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prodrug;
Saccharomyces cerevisiae metabolite
ampicillin
Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.		2.1110beta-lactam antibiotic;
penicillin allergen;
penicillin		antibacterial drug
tryptophan
Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.		2.9840erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan		antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
quinazolines
Quinazolines: A group of aromatic heterocyclic compounds that contain a bicyclic structure with two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring.. quinazoline : A mancude organic heterobicyclic parent that is naphthalene in which the carbon atoms at positions 1 and 3 have been replaced by nitrogen atoms.. quinazolines : Any organic heterobicyclic compound based on a quinazoline skeleton and its substituted derivatives.		2.9840azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
quinazolines
hymexazol
hymexazol: a chemical used to sterilize soil; structure in first source. hymexazol : A member of the class of isoxazoles carrying hydroxy and methyl substituents at positions 3 and 5 respectively. It is used worldwide as a systemic soil and seed fungicide for the control of diseases caused by Fusarium, Aphanomyces, Pythium, and Corticium spp. in rice, sugarbeet, fodderbeet, vegetables, cucurbits, and ornamentals.		2.0710heteroaryl hydroxy compound;
isoxazoles		antifungal agrochemical
carbendazim
carbendazim: carcinogen when combined with sodium nitrite; principle metabolite of thiophanate methyl & benomyl; structure. carbendazim : A member of the class of benzimidazoles that is 2-aminobenzimidazole in which the primary amino group is substituted by a methoxycarbonyl group. A fungicide, carbendazim controls Ascomycetes, Fungi Imperfecti, and Basidiomycetes on a wide variety of crops, including bananas, cereals, cotton, fruits, grapes, mushrooms, ornamentals, peanuts, sugarbeet, soybeans, tobacco, and vegetables.		2.0710benzimidazole fungicide;
benzimidazoles;
benzimidazolylcarbamate fungicide;
carbamate ester		antifungal agrochemical;
antinematodal drug;
metabolite;
microtubule-destabilising agent
cyclo(prolylglycyl)
cyclo(prolylglycyl): RN given is for 17O-labeled cpd		2.0710
glyantrypine
glyantrypine: structure given in first source; an anthranilic acid-containing metabolite isolated from Aspergillus clavatus		7.0210quinazolines
brevianamide f
brevianamide F: isolated from the endophyte from Aspergillus fumigatus associated with Melia azedarach L that could be used to develop a natural eco-friendly herbicide.structure in first source. brevianamide F : A pyrrolopyrazine that is hexahydropyrrolo[1,2-a]pyrazine-1,4-dione bearing an indol-3-ylmethyl substituent at position 3 (the 3S,8aS-diastereomer, obtained by formal cyclocondensation of L-tryptophan and L-proline).		3.6420dipeptide;
indoles;
pyrrolopyrazine		metabolite
bromodeoxytopsentin
bromodeoxytopsentin: from sponge Topsentia pachastrelloides; structure in first source. bromodeoxytopsentin : An aromatic ketone that is imidazole which is substituted by a 1H-indole-3-carbonyl group and a 6-bromo-1H-indol-3-yl group at positions 2 and 4, respectively. Isolated from the Mediterranean shallow-water sponge, Topsentia genetrix. It is a potent inhibitor of MRSA pyruvate kinase and exhibits antibacterial properties.		3.4110aromatic ketone;
bromoindole;
imidazoles;
indole alkaloid		antibacterial agent;
EC 2.7.1.40 (pyruvate kinase) inhibitor;
marine metabolite
tryptoquivaline
fumitremorgin C : An organic heteropentacyclic compound that is a mycotoxic indole alkaloid produced by several fungi. A potent and specific inhibitor of the breast cancer resistance protein multidrug transporter.		2.0710aromatic ether;
indole alkaloid;
organic heteropentacyclic compound		breast cancer resistance protein inhibitor;
mycotoxin
ouabain
Ouabain: A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like DIGITALIS. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-EXCHANGING ATPASE.. cardiac glycoside : Steroid lactones containing sugar residues that act on the contractile force of the cardiac muscles.. ouabain : A steroid hormone that is a multi-hydroxylated alpha-L-rhamnosyl cardenoloide. It binds to and inhibits the plasma membrane Na(+)/K(+)-ATPase (sodium pump). It has been isolated naturally from Strophanthus gratus.		2.111011alpha-hydroxy steroid;
14beta-hydroxy steroid;
5beta-hydroxy steroid;
alpha-L-rhamnoside;
cardenolide glycoside;
steroid hormone		anti-arrhythmia drug;
cardiotonic drug;
EC 2.3.3.1 [citrate (Si)-synthase] inhibitor;
EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor;
ion transport inhibitor;
plant metabolite
deformylflustrabromine
deformylflustrabromine: has antineoplastic activity; isolated from Flustra folicea; structure in first source		3.4110tryptamines
helvolic acid
helvolic acid: structure. helvolic acid : A steroid C-21 acid having a 29-nordammarane skeleton substituted with an acetoxy group at C-16 and oxo groups at C-3 and -7, with double bonds at C-1, -17(20) and -24.		2.07103-oxo-Delta(1) steroid;
acetate ester;
monocarboxylic acid;
steroid acid		antibacterial agent;
fungal metabolite;
mycotoxin
jbp 485
JBP 485: has antihepatitis activity		2.0710
pseurotin
pseurotin: metabolite isolated from culture filtrates of Pseudeurotium ovalis Stolk; structure. pseurotin A : A spirocyclic that is 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione bearing 1,2-dihydroxyhex-3-en-1-yl, methyl, methoxy, benzoyl and hydroxy substituents at positions 2, 3, 8, 8 and 9 respectively.		2.0710azaspiro compound;
lactam;
oxaspiro compound		metabolite
toosendanin
[no description available]		2.0710limonoid
tryprostatin a
tryprostatin A: isolated from Aspergillus fumigatus; a mammalian cell cycle inhibitor; structure given in first source. tryprostatin A : A cyclic dipeptide that is brevianamide F (cyclo-L-Trp-L-Pro) substituted at positions 2 and 6 on the indole ring by prenyl and methoxy groups respectively.		2.0710aromatic ether;
dipeptide;
indole alkaloid;
indoles;
pyrrolopyrazine		breast cancer resistance protein inhibitor
flustramine c
flustramine C: structure in first source		3.4110
fiscalin b
fiscalin B: isolated from culture broth produced by Neosartorya fischeri; inhibits the binding of substance P ligand to human neurokinin receptor; structure given in first source		7.0210
(S)-Isosclerone
[no description available]		2.0710tetralins
fumiquinazoline a
fumiquinazoline A: structure in first source. fumiquinazoline A : A fumiquinazoline that consists of imidazoindole and pyrazinoquinazoline units connected by a methylene group.		2.7730fumiquinazoline;
imidazoindole;
pyrazinoquinazoline
fumiquinazoline c
fumiquinazoline C: structure in first source. fumiquinazoline C : A fumiquinazoline obtained by oxidative spirocyclisation of fumiquinazoline A.		2.110azaspiro compound;
fumiquinazoline;
imidazoindole;
organic heteroheptacyclic compound;
oxaspiro compound
6-methoxyspirotryprostatin b
6-methoxyspirotryprostatin B: cytotoxic compound from the marine-derived fungus Aspergillus sydowi; structure in first source. 6-methoxyspirotryprostatin B : An indole alkaloid isolated from a marine-derived fungal strain Aspergillus sydowii PFW1-13 and has been shown to exhibit cytotoxic activity.		2.0710aromatic ether;
azaspiro compound;
indole alkaloid;
indolones		antineoplastic agent;
Aspergillus metabolite
ConditionIndicatedRelationship StrengthStudiesTrials