| Assay ID | Title | Year | Journal | Article |
|---|
| AID73521 | Efficacy for human GABA-A receptor alpha-5-beta-3-gamma-2 subunits expressed in mammalian fibroblast L(tk-)cells | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition. |
| AID73370 | Percentage modulation of GABA EC20 against human GABA-A receptor alpha-5-beta-3-gamma-2 subunits expressed in Xenopus laevis oocytes | 2002 | Journal of medicinal chemistry, Mar-14, Volume: 45, Issue:6
| 6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists. |
| AID233051 | Binding selectivity for GABA-A alpha5 subunit over GABA-A alpha1,alpha2 or alpha3 subunit receptors | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition. |
| AID1298178 | Inhibition of human recombinant LRRK2 G2019S mutant using fluorescein- ERM as substrate after 1 hr by TR-FRET assay | 2016 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 26, Issue:11
| Potent, selective and orally bioavailable leucine-rich repeat kinase 2 (LRRK2) inhibitors. |
| AID72636 | Selectivity for GABA-A receptor alpha-5 subunit binding over alpha-1,2,3 when co-expressed with beta-3 and gamma-2 | 2002 | Journal of medicinal chemistry, Mar-14, Volume: 45, Issue:6
| 6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists. |
| AID73240 | Efficacy for human GABA-A receptor alpha-3-beta-3-gamma-2 subunits expressed in mammalian fibroblast L(tk-)cells | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition. |
| AID73536 | Maximum modulation relative to GABA EC20 against human GABA-A receptor alpha-5-beta-3-gamma-2 subunits expressed in mammalian fibroblast L(tk-) cells | 2002 | Journal of medicinal chemistry, Mar-14, Volume: 45, Issue:6
| 6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists. |
| AID73520 | Efficacy for GABA-A receptor alpha-5-beta-3-gamma-2 subunits expressed in Xenopus laevis oocytes by two-electrode voltage clamp recording | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition. |
| AID73217 | Displacement of [3H]- Ro 15-1788 binding from human GABA-A receptor alpha-2-beta-3-gamma-2 subunits | 2002 | Journal of medicinal chemistry, Mar-14, Volume: 45, Issue:6
| 6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists. |
| AID73066 | Displacement of [3H]- Ro 15-1788 binding from human GABA-A receptor alpha-1-beta-3-gamma-2 subunits | 2002 | Journal of medicinal chemistry, Mar-14, Volume: 45, Issue:6
| 6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists. |
| AID168377 | Tested for cognitive performance in rats in delayed matching-to-place version of water maze test at 0.3 mg/kg i.p.; Enhanced performance | 2004 | Journal of medicinal chemistry, Jul-01, Volume: 47, Issue:14
| Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site. |
| AID73069 | Maximum modulation relative to GABA EC20 against human GABA-A receptor alpha-1-beta-3-gamma-2 subunits expressed in mammalian fibroblast L(tk-) cells | 2002 | Journal of medicinal chemistry, Mar-14, Volume: 45, Issue:6
| 6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists. |
| AID73531 | Binding affinity to human GABA A alpha-5-beta-3-gamma-2 receptor, using a [3H]-Ro- 15-1788 radioligand | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition. |
| AID1298177 | Inhibition of GST-tagged human recombinant wild type LRRK2 using fluorescein- ERM as substrate after 1 hr by TR-FRET assay | 2016 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 26, Issue:11
| Potent, selective and orally bioavailable leucine-rich repeat kinase 2 (LRRK2) inhibitors. |
| AID72934 | Binding affinity to human gamma-aminobutyric-acid A receptor alpha-1-beta-3-gamma-2, determined using [3H]-Ro- 15-1788 radioligand | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition. |
| AID73219 | Maximum modulation relative to GABA EC20 against human GABA-A receptor alpha-2-beta-3-gamma-2 subunits expressed in mammalian fibroblast L(tk-) cells | 2002 | Journal of medicinal chemistry, Mar-14, Volume: 45, Issue:6
| 6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists. |
| AID73086 | Efficacy for human GABA-A receptor alpha-2-beta-3-gamma-2 subunits expressed in mammalian fibroblast L(tk-)cells | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition. |
| AID73094 | Binding affinity to human gamma-amino butyric-acid A receptor alpha-2-beta-3-gamma-2, using a [3H]-Ro- 15-1788 radioligand | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition. |
| AID72924 | Efficacy for human GABA-A receptor alpha-1-beta-3-gamma-2 subunits expressed in mammalian fibroblast L(tk-)cells | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition. |
| AID72627 | In vivo [3H]L-655708 binding to mouse GABA-A receptor alpha-5 subunit at 3 mg/kg ip dose | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition. |
| AID73246 | Binding affinity to human gamma-amino butyric-acid A receptor alpha-3-beta-3-gamma-2, using a [3H]-Ro- 15-1788 radioligand | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition. |
| AID73361 | Displacement of [3H]- Ro 15-1788 binding from human GABA-A receptor alpha-3-beta-3-gamma-2 subunits | 2002 | Journal of medicinal chemistry, Mar-14, Volume: 45, Issue:6
| 6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists. |
| AID73363 | Maximum modulation relative to GABA EC20 against human GABA-A receptor alpha-3-beta-3-gamma-2 subunits expressed in mammalian fibroblast L(tk-) cells | 2002 | Journal of medicinal chemistry, Mar-14, Volume: 45, Issue:6
| 6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists. |
| AID73532 | Displacement of [3H]- Ro 15-1788 binding from human GABA-A receptor alpha-5-beta-3-gamma-2 subunits | 2002 | Journal of medicinal chemistry, Mar-14, Volume: 45, Issue:6
| 6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |