Page last updated: 2024-12-05

n,n-dimethyl-1-dodecanamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

N,N-dimethyl-1-dodecanamine: increases body weight & feed efficiency in animals; RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID8168
CHEMBL ID109737
SCHEMBL ID107058
MeSH IDM0110582

Synonyms (89)

Synonym
bdbm50147570
dodecyl-dimethyl-amine
112-18-5
armeen dm-12d
dda (corrosion inhibitor)
rc 5629
n-dodecyldimethylamine
dimethyl lauramine
dda (antioxidant)
1-dodecanamine,n-dimethyl-
barlene 125
dodecyldimethylamine
nsc-7332
nsc7332
n,n-dimethyl-n-dodecylamine
n,n-dimethyllaurylamine
dodecylamine,n-dimethyl-
armeen dm 12d
wln: 12n1 & 1
antioxidant dda
dimethyl-n-dodecylamine
lauryldimethylamine
n,n-dimethyldodecylamine
monolauryl dimethylamine
n-lauryldimethylamine
n,n-dimethyldodecan-1-amine
adma 2
ai3-16726
n,n-dimethyl-1-dodecanamine
genamin la 302d
nsc 7332
dimethyl laurylamine
einecs 203-943-8
lauryl dimethyl amine
empigen ab
farmin dm 20
farmin dm 2098
hsdb 5568
dodecylamine, n,n-dimethyl-
1-dodecanamine, n,n-dimethyl-
n,n-dimethyldodecylamine, 97%
NCGC00164121-01
1-(dimethylamino)dodecane
D0002
CHEMBL109737 ,
FT-0653316
AKOS005720939
dtxcid806906
dtxsid1026906 ,
cas-112-18-5
tox21_303073
NCGC00257196-01
BBL011370
STL146467
einecs 269-923-6
sda 16-040-00
ec 269-923-6
ec 269-915-2
68391-04-8
einecs 269-915-2
ec 203-943-8
6v2om30i1z ,
unii-6v2om30i1z
FT-0629557
n,n-dimethyl-1-dodecanamine [hsdb]
dimethyl lauramine [inci]
lauryl dimethylamine
dodecyl dimethyl amine
n,n-dimethyl-dodecylamine
dodecyldimethyl amine
dimethylmono-n-dodecylamine
dimethyldodecylamine
dimethyldodecyl amine
SCHEMBL107058
1-dimethylaminododecane
n,n-dimethyl-1-dodecamine
adma 12
n-dodecyl-n,n-dimethylamine
onamine 12
barlene 12s
kemamine t-6902
W-108655
mfcd00008970
VS-02931
Q24736495
dodecyl dimethylamine
1,1-dimethyl-aminododecane
CS-0297531
EN300-248170

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" Dose-response data were analyzed statistically to determine the concentration for each compound which would inhibit cellulose digestion of VFA production by 50%, thereby providing a convenient reference point for evaluation of the amine with respect to the antibiotics."( Comparison of N,N-dimethyldodecanamine with antibiotics on in vitro cellulose digestion and volatile fatty acid production by ruminal microorganisms.
Baldwin, KA; Bitman, J; Thompson, MJ, 1982
)
0.26
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
farnesoid X nuclear receptorHomo sapiens (human)Potency50.11870.375827.485161.6524AID588526
estrogen nuclear receptor alphaHomo sapiens (human)Potency5.62340.000229.305416,493.5996AID588514
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Dynamin-1Homo sapiens (human)IC50 (µMol)14.79003.15004.17335.0000AID63727
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (11)

Processvia Protein(s)Taxonomy
endocytosisDynamin-1Homo sapiens (human)
receptor-mediated endocytosisDynamin-1Homo sapiens (human)
endosome organizationDynamin-1Homo sapiens (human)
modulation of chemical synaptic transmissionDynamin-1Homo sapiens (human)
protein homooligomerizationDynamin-1Homo sapiens (human)
protein homotetramerizationDynamin-1Homo sapiens (human)
regulation of vesicle sizeDynamin-1Homo sapiens (human)
clathrin coat assembly involved in endocytosisDynamin-1Homo sapiens (human)
vesicle scissionDynamin-1Homo sapiens (human)
receptor internalizationDynamin-1Homo sapiens (human)
synaptic vesicle budding from presynaptic endocytic zone membraneDynamin-1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (11)

Processvia Protein(s)Taxonomy
RNA bindingDynamin-1Homo sapiens (human)
GTPase activityDynamin-1Homo sapiens (human)
protein bindingDynamin-1Homo sapiens (human)
GTP bindingDynamin-1Homo sapiens (human)
phosphatidylinositol-4,5-bisphosphate bindingDynamin-1Homo sapiens (human)
phosphatidylinositol-3,4,5-trisphosphate bindingDynamin-1Homo sapiens (human)
GDP bindingDynamin-1Homo sapiens (human)
protein kinase bindingDynamin-1Homo sapiens (human)
identical protein bindingDynamin-1Homo sapiens (human)
protein homodimerization activityDynamin-1Homo sapiens (human)
microtubule bindingDynamin-1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (15)

Processvia Protein(s)Taxonomy
photoreceptor inner segmentDynamin-1Homo sapiens (human)
plasma membraneDynamin-1Homo sapiens (human)
clathrin-coated pitDynamin-1Homo sapiens (human)
endocytic vesicleDynamin-1Homo sapiens (human)
chromaffin granuleDynamin-1Homo sapiens (human)
cell projectionDynamin-1Homo sapiens (human)
extracellular exosomeDynamin-1Homo sapiens (human)
photoreceptor ribbon synapseDynamin-1Homo sapiens (human)
presynapseDynamin-1Homo sapiens (human)
presynaptic endocytic zone membraneDynamin-1Homo sapiens (human)
glutamatergic synapseDynamin-1Homo sapiens (human)
membrane coatDynamin-1Homo sapiens (human)
plasma membraneDynamin-1Homo sapiens (human)
synapseDynamin-1Homo sapiens (human)
microtubuleDynamin-1Homo sapiens (human)
cytoplasmDynamin-1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID393938Antibacterial activity against Staphylococcus aureus 8325-4 after 18 hrs by broth microdilution method2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Discovery of new inhibitors of the bacterial peptidoglycan biosynthesis enzymes MurD and MurF by structure-based virtual screening.
AID63727Concentration required against dynamin-1 GTPase activity of sheep brain.2004Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
Long chain amines and long chain ammonium salts as novel inhibitors of dynamin GTPase activity.
AID393937Antibacterial activity against AcrAB deficient Escherichia coli SM1411 after 18 hrs by broth microdilution method2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Discovery of new inhibitors of the bacterial peptidoglycan biosynthesis enzymes MurD and MurF by structure-based virtual screening.
AID393936Antibacterial activity against Escherichia coli 1411 after 18 hrs by broth microdilution method2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Discovery of new inhibitors of the bacterial peptidoglycan biosynthesis enzymes MurD and MurF by structure-based virtual screening.
AID393933Inhibition of Escherichia coli MurF assessed as residual activity at 250 uM by malachite green assay2009Bioorganic & medicinal chemistry, Mar-01, Volume: 17, Issue:5
Discovery of new inhibitors of the bacterial peptidoglycan biosynthesis enzymes MurD and MurF by structure-based virtual screening.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (23.08)18.7374
1990's1 (7.69)18.2507
2000's6 (46.15)29.6817
2010's3 (23.08)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.48

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.48 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index5.12 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.48)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies1 (7.69%)4.05%
Observational0 (0.00%)0.25%
Other12 (92.31%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]