Pregnancy, Cornual

A type of pregnancy in which the EMBRYO IMPLANTATION occurs in the horn of the UTERUS instead of in the uterine cavity, i.e. at the junction of the uterus and one of the FALLOPIAN TUBES.

Synonym
Pregnancy, Cornual

Excerpt	Reference
"Cornual pregnancy is a rare entity, representing 2% of ectopic pregnancies."	( Benbara, A; Boujenah, J; Bricou, A; Carbillon, L; Moreaux, G; Nguyen, C; Nikodijevic, K; Poncelet, C, 2016)
"Although cornual pregnancy is a rare form of ectopic pregnancy, the associated mortality rate is considerably higher than that of ectopic pregnancy overall."	( Bardawil, EC; Biest, SW; Cameo, T; de Souza, KM; Min, CJ; Ross, WT, 2023)

Excerpt	Reference
"Early diagnosis and early treatment of cornual pregnancy are very important."	( Huang, H; Li, J; Liu, H; Lu, J; Wang, R; Yang, Y, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	8 (61.54)	28.8240
2020's	5 (38.46)	9.53

Drug	Relationship Strength	Studies
mifepristone	low	3
methotrexate	low	10
carboprost	low	1
misoprostol	low	1
pituitrin	low	1

Protein Targets (227)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	1	0	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
Chain A, Ferritin light chain	2	0	0	2
acid sphingomyelinase	1	0	0	1
dopamine D1 receptor	2	0	0	2
thioredoxin reductase	2	0	0	2
ClpP	1	0	0	1
15-lipoxygenase, partial	1	0	0	1
phosphopantetheinyl transferase	1	0	0	1
ATAD5 protein, partial	3	0	0	3
USP1 protein, partial	2	0	0	2
TDP1 protein	3	0	0	3
Microtubule-associated protein tau	2	0	0	2
AR protein	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	2	0	0	2
estrogen receptor 2 (ER beta)	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	2	0	0	2
progesterone receptor	2	0	0	2
EWS/FLI fusion protein	2	0	0	2
retinoid X nuclear receptor alpha	2	0	0	2
estrogen-related nuclear receptor alpha	2	0	0	2
farnesoid X nuclear receptor	2	0	0	2
estrogen nuclear receptor alpha	3	0	0	3
67.9K protein	1	0	0	1
peroxisome proliferator-activated receptor delta	2	0	0	2
peroxisome proliferator activated receptor gamma	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	2	0	0	2
Thymidylate synthase	0	1	0	1
alpha-galactosidase	1	0	0	1
IDH1	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	3	0	0	3
Thymidylate synthase	0	1	0	1
Histone H2A.x	2	0	0	2
Bloom syndrome protein isoform 1	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
vitamin D3 receptor isoform VDRA	3	0	0	3
chromobox protein homolog 1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
transcriptional regulator ERG isoform 3	1	0	0	1
thyroid hormone receptor beta isoform 2	2	0	0	2
importin subunit beta-1 isoform 1	1	0	0	1
DNA polymerase beta	2	0	0	2
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
flap endonuclease 1	1	0	0	1
snurportin-1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	2	0	0	2
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
geminin	3	0	0	3
DNA polymerase kappa isoform 1	1	0	0	1
peripheral myelin protein 22	3	0	0	3
survival motor neuron protein isoform d	2	0	0	2
M-phase phosphoprotein 8	2	0	0	2
muscleblind-like protein 1 isoform 1	1	0	0	1
histone acetyltransferase KAT2A isoform 1	2	0	0	2
caspase-1 isoform alpha precursor	1	0	0	1
lamin isoform A-delta10	3	0	0	3
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	2	0	2
Multidrug resistance-associated protein 4	0	2	0	3
Bile salt export pump	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Voltage-dependent calcium channel gamma-2 subunit	2	0	0	2
Bile salt export pump	0	2	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Carbonic anhydrase 2	0	0	1	1
Cellular tumor antigen p53	3	0	0	3
Thymidylate synthase	0	2	0	2
Integrin beta-3	1	0	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Integrin alpha-IIb	1	0	0	1
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Glutamate receptor 2	2	0	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Spike glycoprotein	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
TAR DNA-binding protein 43	1	0	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	2	0	2
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
ATPase family AAA domain-containing protein 5	3	0	0	3
Ataxin-2	3	0	0	3
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	0	0	1
ATP-dependent phosphofructokinase	2	0	0	2
Chain A, Beta-lactamase	1	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Chain A, PROGESTERONE RECEPTOR	0	1	0	1
Chain A, Cruzipain	2	0	0	2
Glucocorticoid receptor	0	1	0	1
glp-1 receptor, partial	1	0	0	1
pregnane X receptor	1	0	0	1
RAR-related orphan receptor gamma	1	0	0	1
SMAD family member 2	1	0	0	1
Fumarate hydratase	1	0	0	1
GLS protein	1	0	0	1
SMAD family member 3	1	0	0	1
GLI family zinc finger 3	1	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
hypothetical protein, conserved	1	0	0	1
regulator of G-protein signaling 4	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	2	0	0	2
nonstructural protein 1	1	0	0	1
glucocorticoid receptor [Homo sapiens]	1	0	0	1
retinoic acid nuclear receptor alpha variant 1	1	0	0	1
pregnane X nuclear receptor	1	0	0	1
G	2	0	0	2
cytochrome P450 2D6	2	0	0	2
polyprotein	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	1	0	0	1
activating transcription factor 6	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
D(1A) dopamine receptor	1	0	0	1
heat shock protein beta-1	1	0	0	1
huntingtin isoform 2	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
nuclear receptor ROR-gamma isoform 1	2	0	0	2
neuropeptide S receptor isoform A	2	0	0	2
Interferon beta	2	0	0	2
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Estrogen receptor	1	2	1	4
Glucocorticoid receptor	1	2	2	7
Prostaglandin G/H synthase 1	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Progesterone receptor	0	2	1	5
Tegument protein VP16	0	0	1	1
Glucocorticoid receptor	0	1	1	3
Glucocorticoid receptor	0	1	0	1
Glycine receptor subunit alpha-1	0	2	0	2
Mineralocorticoid receptor	1	2	1	5
Cytochrome P450 3A4	0	2	0	2
Coagulation factor VII	0	1	0	1
Androgen receptor	1	2	1	4
Cytochrome P450 2C8	0	1	0	1
Thyroid hormone receptor alpha	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Cytochrome P450 2C9	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Tissue factor	0	1	0	1
Androgen receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	1	0	1
Glycine receptor subunit beta	0	2	0	2
ATP-dependent translocase ABCB1	0	0	1	1
Glycine receptor subunit alpha-2	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Glycine receptor subunit alpha-3	0	2	0	2
Adenosine receptor A1	0	0	1	1
Adenosine receptor A2a	0	0	1	1
Substance-P receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
D(1A) dopamine receptor	1	0	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Progesterone receptor	0	0	1	1
Inositol hexakisphosphate kinase 1	2	0	0	2
Estrogen receptor beta	1	2	1	4
Sigma non-opioid intracellular receptor 1	0	2	0	2
Glucocorticoid receptor	0	1	0	1
cytochrome P450 2C9, partial	2	0	0	2
thioredoxin glutathione reductase	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (13)

Protein Targets (227)

Pregnancy, Cornual

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (13)

Drugs Studied (5)

Protein Targets (227)