Compounds > 3-amino-2-hydroxy-5-methylhexanoic acid
Page last updated: 2024-11-08

3-amino-2-hydroxy-5-methylhexanoic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3-amino-2-hydroxy-5-methylhexanoic acid: structure given in first source; RN given refers to cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID173844
SCHEMBL ID2452941
MeSH IDM0106270

Synonyms (12)

Synonym
ahmha
norstatine
3-amino-2-hydroxy-5-methylhexanoic acid
hexanoic acid, 3-amino-2-hydroxy-5-methyl-
62023-30-7
AKOS013566937
SCHEMBL2452941
l-asparticaciddiethylesterhydrochloride
GZLMFCWSEKVVGO-UHFFFAOYSA-N
3-amino-2-hydroxy-5-methyl hexanoic acid
DTXSID00977561
EN300-322675

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" Its bioactive monomethylamine metabolite (35, CP-108,671) was subsequently found to have uniformly high oral bioavailability and activity in various species including primates."( Discovery of inhibitors of human renin with high oral bioavailability.
Bindra, JS; Hockel, GM; Holt, WF; Hoover, DJ; Kleinman, EF; Lefker, BA; Mangiapane, ML; Murphy, WR; Rosati, RL; Wester, RT, 1995)		0.29
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (13.33)18.7374
1990's4 (26.67)18.2507
2000's7 (46.67)29.6817
2010's2 (13.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.73

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.73 (24.57)
Research Supply Index2.89 (2.92)
Research Growth Index4.62 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.73)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
glycine
[no description available]		2.0210alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
oxazoles
Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.		2.07101,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
statine
statine: amine component of pepstatin; structure		2.3820
3-amino-2-hydroxy-4-phenylbutanoic acid
[no description available]		210
alpha-chymotrypsin
Chymotrypsin: A serine endopeptidase secreted by the pancreas as its zymogen, CHYMOTRYPSINOGEN and carried in the pancreatic juice to the duodenum where it is activated by TRYPSIN. It selectively cleaves aromatic amino acids on the carboxyl side.		1.9810
ConditionIndicatedRelationship StrengthStudiesTrials
HIV Coinfection
[description not available]		02.1110
HIV Infections
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).		02.1110
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		01.9610