racepinephrine has been researched along with Acute Disease in 23 studies
Racepinephrine: A racemic mixture of d-epinephrine and l-epinephrine.
4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol : A catecholamine in which the aminoethyl side-chain is hydroxy-substituted at C-1 and methylated on nitrogen.
Acute Disease: Disease having a short and relatively severe course.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In children up to the 18th month of life, ED treatment of bronchiolitis with nebulized racemic albuterol led to more successful discharges than nebulized epinephrine." | 9.13 | Comparison of nebulized epinephrine to albuterol in bronchiolitis. ( Caldwell, J; Friese, S; McQuillan, KK; Robbins, D; Rothenberg, SJ; Walsh, P, 2008) |
| "To determine if nebulized epinephrine is more efficacious than nebulized albuterol in the emergency department (ED) treatment of moderately ill infants with bronchiolitis." | 9.11 | A randomized trial of nebulized epinephrine vs albuterol in the emergency department treatment of bronchiolitis. ( Bechtel, KA; Carlin, T; Ferri, LR; Gracely, EJ; Mull, CC; Rissman, RL; Salvaggio, C; Scarfone, RJ; Trephan, MA, 2004) |
| "Our objective was to determine if nebulized racemic epinephrine is more efficacious than nebulized albuterol or saline placebo in the treatment of bronchiolitis in the outpatient setting when dosing is equivalent in terms of beta-2 agonist potency." | 9.11 | Randomized, placebo-controlled trial of albuterol and epinephrine at equipotent beta-2 agonist doses in acute bronchiolitis. ( Anaya, T; Hartenberger, C; Kelly, HW; Qualls, C; Ralston, S, 2005) |
| "To investigate whether nebulized racemic epinephrine or albuterol improves respiratory distress in infants with acute bronchiolitis." | 9.08 | The clinical efficacy of nebulized racemic epinephrine and albuterol in acute bronchiolitis. ( Korppi, M; Pitkäkangas, S; Reijonen, T; Remes, K; Tenhola, S, 1995) |
| "In children up to the 18th month of life, ED treatment of bronchiolitis with nebulized racemic albuterol led to more successful discharges than nebulized epinephrine." | 5.13 | Comparison of nebulized epinephrine to albuterol in bronchiolitis. ( Caldwell, J; Friese, S; McQuillan, KK; Robbins, D; Rothenberg, SJ; Walsh, P, 2008) |
| "To determine if nebulized epinephrine is more efficacious than nebulized albuterol in the emergency department (ED) treatment of moderately ill infants with bronchiolitis." | 5.11 | A randomized trial of nebulized epinephrine vs albuterol in the emergency department treatment of bronchiolitis. ( Bechtel, KA; Carlin, T; Ferri, LR; Gracely, EJ; Mull, CC; Rissman, RL; Salvaggio, C; Scarfone, RJ; Trephan, MA, 2004) |
| "Our objective was to determine if nebulized racemic epinephrine is more efficacious than nebulized albuterol or saline placebo in the treatment of bronchiolitis in the outpatient setting when dosing is equivalent in terms of beta-2 agonist potency." | 5.11 | Randomized, placebo-controlled trial of albuterol and epinephrine at equipotent beta-2 agonist doses in acute bronchiolitis. ( Anaya, T; Hartenberger, C; Kelly, HW; Qualls, C; Ralston, S, 2005) |
| "To investigate whether nebulized racemic epinephrine or albuterol improves respiratory distress in infants with acute bronchiolitis." | 5.08 | The clinical efficacy of nebulized racemic epinephrine and albuterol in acute bronchiolitis. ( Korppi, M; Pitkäkangas, S; Reijonen, T; Remes, K; Tenhola, S, 1995) |
| "In the treatment of acute bronchiolitis in infants, inhaled racemic adrenaline is not more effective than inhaled saline." | 2.78 | Racemic adrenaline and inhalation strategies in acute bronchiolitis. ( Brügmann-Pieper, SK; Brun, AC; Carlsen, KH; Engen, H; Eskedal, L; Haavaldsen, M; Hunderi, JO; Kvenshagen, B; Lunde, J; Lødrup Carlsen, KC; Mowinckel, P; Rolfsjord, LB; Siva, C; Skjerven, HO; Vikin, T, 2013) |
| " The highest dose used in the dose-response trials (=0." | 2.65 | Inhalation of racemic epinephrine in children with asthma. Dose-response relation and comparison with salbutamol. ( Kjellman, B; Tollig, H; Wettrell, G, 1980) |
| "Laryngeal dyspnea is a life-threatening emergency situation." | 2.42 | [Acute laryngeal dyspnea]. ( Cros, AM; Hervé, Y, 2003) |
| " Future studies need to examine dosing of glucocorticoids for inpatients with croup." | 2.40 | Recent advances in the treatment of bronchiolitis and laryngitis. ( Klassen, TP, 1997) |
| "Acute laryngitis is the most common form of upper airway obstruction in young children." | 2.38 | [Acute laryngitis in children]. ( Dobrescu, O; Geoffroy, L; Rousseau, E, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (34.78) | 18.7374 |
| 1990's | 6 (26.09) | 18.2507 |
| 2000's | 8 (34.78) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Skjerven, HO | 1 |
| Hunderi, JO | 1 |
| Brügmann-Pieper, SK | 1 |
| Brun, AC | 1 |
| Engen, H | 1 |
| Eskedal, L | 1 |
| Haavaldsen, M | 1 |
| Kvenshagen, B | 1 |
| Lunde, J | 1 |
| Rolfsjord, LB | 1 |
| Siva, C | 1 |
| Vikin, T | 1 |
| Mowinckel, P | 1 |
| Carlsen, KH | 3 |
| Lødrup Carlsen, KC | 3 |
| Grewal, S | 1 |
| Ali, S | 1 |
| McConnell, DW | 1 |
| Vandermeer, B | 1 |
| Klassen, TP | 2 |
| Hariprakash, S | 1 |
| Alexander, J | 1 |
| Carroll, W | 1 |
| Ramesh, P | 1 |
| Randell, T | 1 |
| Turnbull, F | 1 |
| Lenney, W | 1 |
| Cros, AM | 1 |
| Hervé, Y | 1 |
| Mull, CC | 1 |
| Scarfone, RJ | 1 |
| Ferri, LR | 1 |
| Carlin, T | 1 |
| Salvaggio, C | 1 |
| Bechtel, KA | 1 |
| Trephan, MA | 1 |
| Rissman, RL | 1 |
| Gracely, EJ | 1 |
| Ralston, S | 1 |
| Hartenberger, C | 1 |
| Anaya, T | 1 |
| Qualls, C | 1 |
| Kelly, HW | 1 |
| Wiebe, K | 1 |
| Rowe, BH | 1 |
| Walsh, P | 1 |
| Caldwell, J | 1 |
| McQuillan, KK | 1 |
| Friese, S | 1 |
| Robbins, D | 1 |
| Rothenberg, SJ | 1 |
| Rowe, LD | 1 |
| Kjellman, B | 1 |
| Tollig, H | 1 |
| Wettrell, G | 1 |
| Reijonen, T | 1 |
| Korppi, M | 1 |
| Pitkäkangas, S | 1 |
| Tenhola, S | 1 |
| Remes, K | 1 |
| Kristjánsson, S | 1 |
| Wennergren, G | 1 |
| Strannegård, IL | 1 |
| Jones, JS | 1 |
| Hendricks, J | 1 |
| Westley, CR | 1 |
| Cotton, EK | 1 |
| Brooks, JG | 1 |
| Taussig, LM | 1 |
| Castro, O | 1 |
| Beaudry, PH | 1 |
| Fox, WW | 1 |
| Bureau, M | 1 |
| Breivik, H | 1 |
| Dobrescu, O | 1 |
| Geoffroy, L | 1 |
| Rousseau, E | 1 |
| Sivan, Y | 1 |
| Deakers, TW | 1 |
| Newth, CJ | 1 |
| Super, DM | 1 |
| Cartelli, NA | 1 |
| Brooks, LJ | 1 |
| Lembo, RM | 1 |
| Kumar, ML | 1 |
| Kissoon, N | 1 |
| Mitchell, I | 1 |
| Gardner, HG | 1 |
| Powell, KR | 1 |
| Roden, VJ | 1 |
| Cherry, JD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Bronchiolitis All-study, SE-Norway What is the Optimal Inhalation Treatment for Children 0-12 Months With Acute Bronchiolitis?[NCT00817466] | Phase 4 | 500 participants (Anticipated) | Interventional | 2010-01-31 | Active, not recruiting | ||
| A Randomized Trial of Nebulized 3% Hypertonic Saline With Salbutamol in the Treatment of Acute Bronchiolitis in Pediatric Hospital[NCT02233985] | Phase 4 | 64 participants (Actual) | Interventional | 2013-08-31 | Completed | ||
| Nebulized Hypertonic Saline for Acute Bronchiolitis in the Emergency Department[NCT01247064] | Phase 4 | 62 participants (Actual) | Interventional | 2010-10-31 | Completed | ||
| Randomized Controlled Trial of Epinephrine and Albuterol in Bronchiolitis[NCT00114478] | 600 participants | Interventional | 2003-11-30 | Active, not recruiting | |||
| "Are Steroids Efficacious in Hospitalized Patients With Bronchiolitis Who Show an Objective Clinical Improvement After Albuterol (Albuterol Responders)?"[NCT00798616] | 0 participants (Actual) | Interventional | Withdrawn (stopped due to We were unable to enroll a sufficient number of patients due to manpower.) | ||||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Each patient record the time of entry and measured the total hospital stay time in hours, recording the time of discharge to determine the total stay in hours. The hospital stay will be evaluated in hours. Staying hospitalized until they had mild respiratory stage scale scores for at least 2 hrs. (NCT02233985)
Timeframe: Throughout the stay for each patient until discharge. Follow-up will be continued for a period of 30 days in which they may present readmissions, complications or adverse effects.
| Intervention | hours (Median) |
|---|---|
| Hypertonic Saline Solution 3% (SHS 3%) | 8 |
| Saline Solution 0.9% (SS 0.9%) Group | 39.3 |
It is a validated clinical scale, sufficiently reliable measure of Severity of the respiratory distress. It consists of the summation score of the sibilance / crackling parameters (the largest of them), respiratory effort, pulmonary air inlet, oxygen saturation, heart rate and breathing rate. It is stratified into 3 levels of severity: mild from 0 to 5 points, moderate from 6 to 10 and severe from 10 to 16. (NCT02233985)
Timeframe: Basal, 30 minutes after the end of the first 3 continuous nebulization sessions, at 4 hours, 8 hours and every 24 hours during the entire hospital stay
| Intervention | units on a scale (Median) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Basal | 30 minutes | 4 hours | 8 hours | 12 hours | 24 hours | 48 hours | 72 hours | 96 hours | 120 hours | 144 hours | 196 hours | |
| Hypertonic Saline Solution 3% (HSS 3%) Group | 8 | 6 | 5 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Saline Solution 0.9% (SS 0.9%) Group | 8 | 8 | 8 | 8 | 7 | 7 | 7 | 6 | 5 | 3 | 6 | 4 |
(NCT01247064)
Timeframe: Baseline and 1 hour
| Intervention | percent (Mean) |
|---|---|
| Nebulized 3% Saline | 1.1 |
| Nebulized 0.9% Normal Saline | 0.1 |
(NCT01247064)
Timeframe: 1 hour
| Intervention | percentage of participants (Number) |
|---|---|
| Nebulized 3% Saline | 50 |
| Nebulized 0.9% Normal Saline | 54.8 |
(NCT01247064)
Timeframe: 1 day
| Intervention | percentage of participants (Number) |
|---|---|
| Nebulized 3% Saline | 71 |
| Nebulized 0.9% Normal Saline | 64.5 |
The Respiratory Assessment Change Score (RACS) assesses change in respiratory status using the change in the Respiratory Distress Assessment Instrument (RDAI) and a standardized change in respiratory rate, with points being assigned by change increments of 10%. Thus, a change in respiratory rate of ≤5% from baseline counted as a change of 0 units, decrease/increase of 6% to 15% counted as improvement/deterioration of 1 unit, etc. The overall RACS is the arithmetic sum of the RDAI change and the standardized respiratory rate change between assessments with a decrease in RACS signifying improvement. (NCT01247064)
Timeframe: Baseline and 1 hour
| Intervention | units on a scale (Mean) |
|---|---|
| Nebulized 3% Saline | -1.5 |
| Nebulized 0.9% Normal Saline | -4 |
(NCT01247064)
Timeframe: Baseline and 1 hour
| Intervention | breaths per minute (Mean) |
|---|---|
| Nebulized 3% Saline | -1.8 |
| Nebulized 0.9% Normal Saline | -9.8 |
5 reviews available for racepinephrine and Acute Disease
| Article | Year |
|---|---|
[Acute laryngeal dyspnea].
Topics: Acute Disease; Airway Obstruction; Anti-Inflammatory Agents; Bronchodilator Agents; Dyspnea; Epineph | 2003 |
Nebulized racemic epinephrine used in the treatment of severe asthmatic exacerbation: a case report and literature review.
Topics: Acute Disease; Adult; Asthma; Bronchodilator Agents; Epinephrine; Female; Humans; Nebulizers and Vap | 2007 |
Advances and controversies in the management of supraglottitis and laryngotracheobronchitis.
Topics: Acute Disease; Bronchitis; Child; Child, Preschool; Dexamethasone; Epinephrine; Evaluation Studies a | 1980 |
Recent advances in the treatment of bronchiolitis and laryngitis.
Topics: Acute Disease; Bronchiolitis; Bronchodilator Agents; Child, Preschool; Epinephrine; Glucocorticoids; | 1997 |
[Acute laryngitis in children].
Topics: Acute Disease; Bacterial Infections; Child; Epinephrine; Humans; Laryngitis; Racepinephrine; Steroid | 1992 |
13 trials available for racepinephrine and Acute Disease
| Article | Year |
|---|---|
Racemic adrenaline and inhalation strategies in acute bronchiolitis.
Topics: Acute Disease; Administration, Inhalation; Age Factors; Bronchiolitis; Combined Modality Therapy; Do | 2013 |
A randomized trial of nebulized 3% hypertonic saline with epinephrine in the treatment of acute bronchiolitis in the emergency department.
Topics: Acute Disease; Age Factors; Asthma; Bronchiolitis, Viral; Bronchodilator Agents; Double-Blind Method | 2009 |
A randomized trial of nebulized 3% hypertonic saline with epinephrine in the treatment of acute bronchiolitis in the emergency department.
Topics: Acute Disease; Age Factors; Asthma; Bronchiolitis, Viral; Bronchodilator Agents; Double-Blind Method | 2009 |
A randomized trial of nebulized 3% hypertonic saline with epinephrine in the treatment of acute bronchiolitis in the emergency department.
Topics: Acute Disease; Age Factors; Asthma; Bronchiolitis, Viral; Bronchodilator Agents; Double-Blind Method | 2009 |
A randomized trial of nebulized 3% hypertonic saline with epinephrine in the treatment of acute bronchiolitis in the emergency department.
Topics: Acute Disease; Age Factors; Asthma; Bronchiolitis, Viral; Bronchodilator Agents; Double-Blind Method | 2009 |
Randomized controlled trial of nebulized adrenaline in acute bronchiolitis.
Topics: Acute Disease; Administration, Inhalation; Bronchiolitis; Bronchodilator Agents; Double-Blind Method | 2003 |
A randomized trial of nebulized epinephrine vs albuterol in the emergency department treatment of bronchiolitis.
Topics: Acute Disease; Administration, Inhalation; Albuterol; Bronchiolitis; Bronchodilator Agents; Double-B | 2004 |
Randomized, placebo-controlled trial of albuterol and epinephrine at equipotent beta-2 agonist doses in acute bronchiolitis.
Topics: Acute Disease; Adrenergic beta-Agonists; Albuterol; Bronchiolitis; Double-Blind Method; Epinephrine; | 2005 |
Comparison of nebulized epinephrine to albuterol in bronchiolitis.
Topics: Acute Disease; Administration, Inhalation; Albuterol; Bronchiolitis; Bronchodilator Agents; Double-B | 2008 |
Inhalation of racemic epinephrine in children with asthma. Dose-response relation and comparison with salbutamol.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Albuterol; Asthma; Child; Dose-Response Relat | 1980 |
The clinical efficacy of nebulized racemic epinephrine and albuterol in acute bronchiolitis.
Topics: Acute Disease; Albuterol; Bronchiolitis; Double-Blind Method; Epinephrine; Female; Heart Rate; Human | 1995 |
Nebulised racemic adrenaline in the treatment of acute bronchiolitis in infants and toddlers.
Topics: Acute Disease; Administration, Inhalation; Blood Gas Monitoring, Transcutaneous; Blood Pressure; Bro | 1993 |
Nebulized racemic epinephrine by IPPB for the treatment of croup: a double-blind study.
Topics: Acute Disease; Aerosols; Child, Preschool; Clinical Trials as Topic; Croup; Double-Blind Method; Epi | 1978 |
Treatment of laryngotracheobronchitis (croup). Use of intermittent positive-pressure breathing and racemic epinephrine.
Topics: Acute Disease; Aerosols; Carbon Dioxide; Child; Child, Preschool; Clinical Trials as Topic; Croup; E | 1975 |
A prospective randomized double-blind study to evaluate the effect of dexamethasone in acute laryngotracheitis.
Topics: Acute Disease; Adolescent; Adult; Child; Child, Preschool; Croup; Dexamethasone; Double-Blind Method | 1989 |
The evaluation of racemic epinephrine in the treatment of infectious croup.
Topics: Acute Disease; Aerosols; Child, Hospitalized; Child, Preschool; Clinical Trials as Topic; Epinephrin | 1973 |
5 other studies available for racepinephrine and Acute Disease
| Article | Year |
|---|---|
Racemic epinephrine in the treatment of laryngotracheitis: can relapse be prevented?
Topics: Acute Disease; Bronchodilator Agents; Child; Child, Preschool; Croup; Emergency Medical Services; Ep | 1996 |
Inhaled nebulized adrenaline improves lung function in infants with acute bronchiolitis.
Topics: Acute Disease; Administration, Inhalation; Adrenergic Agonists; Bronchiolitis; Epinephrine; Female; | 2000 |
[Treatment of acute laryngitis with nebulized racemic adrenaline].
Topics: Acute Disease; Aerosols; Epinephrine; Laryngitis; Racepinephrine | 1975 |
Thoracoabdominal asynchrony in acute upper airway obstruction in small children.
Topics: Abdomen; Acute Disease; Airway Obstruction; Child, Preschool; Croup; Epinephrine; Humans; Infant; In | 1990 |
Adverse effects of racemic epinephrine in epiglottitis.
Topics: Acute Disease; Airway Obstruction; Child, Preschool; Diagnosis, Differential; Epiglottitis; Epinephr | 1985 |