gw-9578 has been researched along with Hyperlipidemias* in 2 studies
1 review(s) available for gw-9578 and Hyperlipidemias
| Article | Year |
|---|---|
The PPARs: from orphan receptors to drug discovery.
Topics: Animals; Diabetes Mellitus; Drug Design; Humans; Hyperlipidemias; Hypertension; Inflammation; Ligands; Models, Molecular; Neoplasms; Nuclear Proteins; Obesity; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2000 |
1 other study(ies) available for gw-9578 and Hyperlipidemias
| Article | Year |
|---|---|
Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis.
Using solid-phase, parallel-array synthesis, a series of urea-substituted thioisobutyric acids was synthesized and assayed for activity on the human PPAR subtypes. GW7647 (3) was identified as a potent human PPARalpha agonist with approximately 200-fold selectivity over PPARgamma and PPARdelta, and potent lipid-lowering activity in animal models of dyslipidemia. GW7647 (3) will be a valuable chemical tool for studying the biology of PPARalpha in human cells and animal models of disease. Topics: Animals; Butyrates; Cricetinae; Dietary Fats; Drug Design; Hyperlipidemias; Hypolipidemic Agents; Phenylurea Compounds; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2001 |