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dATP diphosphatase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: dATP + H2O = dAMP + H+ + diphosphate. [GOC:pde, PMID:11139615, RHEA:28334]

dATP diphosphatase activity catalyzes the hydrolysis of deoxyadenosine triphosphate (dATP) to deoxyadenosine monophosphate (dAMP) and inorganic pyrophosphate (PPi). This reaction is essential for maintaining the proper balance of deoxyribonucleotide triphosphates (dNTPs) in the cell, which are required for DNA synthesis. dATP diphosphatase activity is involved in several cellular processes, including DNA replication, repair, and recombination. It also plays a role in the regulation of DNA synthesis by controlling the availability of dATP. The enzyme is typically found in the cytoplasm and nucleus of cells. It is often associated with other enzymes involved in DNA metabolism, such as DNA polymerase and DNA ligase. Mutations in genes encoding dATP diphosphatase can lead to a variety of human diseases, including cancer and immune deficiencies.'
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Proteins (1)

ProteinDefinitionTaxonomy
7,8-dihydro-8-oxoguanine triphosphataseAn oxidized purine nucleoside triphosphate hydrolase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P36639]Homo sapiens (human)

Compounds (19)

CompoundDefinitionClassesRoles
kinetincytokinin : A phytohormone that promote cell division, or cytokinesis, in plant roots and shoots.

kinetin : A member of the class of 6-aminopurines that is adenine carrying a (furan-2-ylmethyl) substituent at the exocyclic amino group.

Kinetin: A furanyl adenine found in PLANTS and FUNGI. It has plant growth regulation effects.
6-aminopurines;
furans
cytokinin;
geroprotector
7-azaindolepyrrolopyridine
2-aminobenzimidazole2-aminobenzimidazole : A member of the class of benzimidazoles that is benzimidazole in which the hydrogen at position 2 is replaced by an amino group.

2-aminobenzimidazole: metabolite of benomyl; RN given refers to parent cpd
benzimidazolesmarine xenobiotic metabolite
imiquimodimiquimod : An imidazoquinoline fused [4,5-c] carrying isobutyl and amino substituents at N-1 and C-4 respectively. A prescription medication, it acts as an immune response modifier and is used to treat genital warts, superficial basal cell carcinoma, and actinic keratosis.

Imiquimod: A topically-applied aminoquinoline immune modulator that induces interferon production. It is used in the treatment of external genital and perianal warts, superficial CARCINOMA, BASAL CELL; and ACTINIC KERATOSIS.
imidazoquinolineantineoplastic agent;
interferon inducer
1h-imidazo(4,5-b)pyridine1H-imidazo(4,5-b)pyridine: structure given in first source

4-azabenzimidazole : The [4,5-b]-fused isomer of imidazopyridine.
imidazopyridine
resiquimodS 28463: structure given in first sourceimidazoquinoline
4-methyl-2-quinazolinamine4-methyl-2-quinazolinamine: from Streptomyces of TCM plant; structure in first source
8-deoxygartanin8-deoxygartanin: a butyrylcholinesterase inhibitor; isolated from Garcinia mangostana; structure in first sourcexanthones
zeatinZeatin: An aminopurine factor in plant extracts that induces cell division. (Grant & Hackh's Chemical Dict, 5th ed)zeatinplant metabolite
mangostinalpha-mangostin : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities.

mangostin: xanthone from rind of Garcinia mangostana Linn. fruit
aromatic ether;
phenols;
xanthones
antimicrobial agent;
antineoplastic agent;
antioxidant;
plant metabolite
norathyriolnorathyriol : A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 3, 6 and 7. Isolated from Garcinia mangostana and Maclura pomifera, it exhibits inhibitory activity against protein kinase C.

norathyriol: from Gentinanaceae; has vasorelaxing action on rat thoracic aorta; structure given in first source
polyphenol;
xanthones
antineoplastic agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
plant metabolite
gamma-mangostingamma-mangostin : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3, 6 and 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antitumour activity.phenols;
xanthones
antineoplastic agent;
plant metabolite;
protein kinase inhibitor
1,3,7-trihydroxy-2-(3-methylbut-2-enyl)-xanthone1,3,7-trihydroxy-2-(3-methylbut-2-enyl)-xanthone: from stems of Kielmeyera coriacea; structure in first source
sch 51344SCH 51344: inhibits ras transformation; structure given in first source

SCH51344 : A pyrazoloquinoline that is 6-methoxy-3-methyl-1H-pyrazolo[3,4-b]quinoline bearing an additional 2-[(2-hydroxyethoxy)ethyl]amino substituent at position 4
aromatic amine;
aromatic ether;
primary alcohol;
pyrazoloquinoline;
secondary amino compound
antineoplastic agent
3,4,5,6-tetrahydroxyxanthone
sm360320SM360320: Proc Natl Acad Sci U S A 2006 Feb 7;103(6):1828-33
3-isomangostin3-isomangostin: structure in first sourcexanthones
garcinone cgarcinone C: an acetylcholinesterase inhibitor; isolated from Garcinia mangostana; structure in first sourcexanthones
ent-crizotinibent-crizotinib : A 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine that is the (S)-enantiomer of crizotinib.3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine