| Assay ID | Title | Year | Journal | Article |
|---|
| AID1357472 | Growth inhibition of human HepG2 cells after 24 hrs by MTT assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Incorporation of nitric oxide donor into 1,3-dioxyxanthones leads to synergistic anticancer activity. |
| AID289303 | Growth inhibition of human SF268 cells | 2007 | Bioorganic & medicinal chemistry, Sep-15, Volume: 15, Issue:18
| Dihydroxyxanthones prenylated derivatives: synthesis, structure elucidation, and growth inhibitory activity on human tumor cell lines with improvement of selectivity for MCF-7. |
| AID1464407 | Inhibition of recombinant human topoisomerase-2alpha expressed in Saccharomyces cerevisiae JEL1 harboring topoisomerase1 deletion mutant assessed as enzyme-mediated supercoiled pBR322 cleavable complex formation up to 10 uM in presence of CaCl2 by ethidiu | 2017 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 27, Issue:20
| Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase IIα. |
| AID1496399 | Inhibition of Saccharomyces cerevisiae alpha-glucosidase using PNP glycoside as substrate preincubated for 30 mins followed by substrate addition measured after 60 secs by spectrophotometric method | 2018 | Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12
| Novel oxazolxanthone derivatives as a new type of α-glucosidase inhibitor: synthesis, activities, inhibitory modes and synergetic effect. |
| AID1357474 | Growth inhibition of human MCF7 cells after 24 hrs by MTT assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Incorporation of nitric oxide donor into 1,3-dioxyxanthones leads to synergistic anticancer activity. |
| AID657726 | Antibacterial activity against Moraxella catarrhalis ATCC 23246 after 20 to 22 hrs by broth microdilution method | 2012 | Bioorganic & medicinal chemistry, May-15, Volume: 20, Issue:10
| An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization. |
| AID361498 | Inhibition of yeast alpha glucosidase in phosphate buffer after 0.5 hrs by spectrophotometry | 2008 | Bioorganic & medicinal chemistry, Aug-01, Volume: 16, Issue:15
| Synthesis, inhibitory activities, and QSAR study of xanthone derivatives as alpha-glucosidase inhibitors. |
| AID1597635 | Induction of glucose uptake in human HepG2 cells at 0.625 to 2.5 uM incubated for 24 hrs in low glucose medium | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Design and synthesis of novel xanthone-triazole derivatives as potential antidiabetic agents: α-Glucosidase inhibition and glucose uptake promotion. |
| AID1464404 | Ratio of IC50 for recombinant human topoisomerase-2alpha expressed in Saccharomyces cerevisiae JEL1 harboring topoisomerase1 deletion mutant assessed as enzyme-mediated decatenation of kinetoplast DNA to IC50 for recombinant human topoisomerase-2alpha cat | 2017 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 27, Issue:20
| Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase IIα. |
| AID1478622 | Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by CCK8 assay | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Synthesis of xanthone derivatives and studies on the inhibition against cancer cells growth and synergistic combinations of them. |
| AID1464405 | Inhibition of recombinant human topoisomerase-2alpha catalytic activity expressed in Saccharomyces cerevisiae JEL1 harboring topoisomerase1 deletion mutant assessed as reduction in supercoiled pBR322 DNA relaxation at 10 uM in presence of spermine by ethi | 2017 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 27, Issue:20
| Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase IIα. |
| AID1520336 | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Mar-15, Volume: 166 | All that glitters is not gold: Panning cytotoxic natural products and derivatives with a fused tricyclic backbone by the estimation of their leadlikeness for cancer treatment. |
| AID661918 | Antiviral activity against Influenza A virus PR/8/34 H1N1 infected in dog MDCK cells assessed as reduction in virus-induced cytopathic effect at 5 ug/mL | 2012 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11
| Xanthones from Polygala karensium inhibit neuraminidases from influenza A viruses. |
| AID287846 | Inhibition of yeast alpha glucosidase at pH 6.8 | 2007 | Bioorganic & medicinal chemistry, Apr-15, Volume: 15, Issue:8
| Synthesis of xanthone derivatives with extended pi-systems as alpha-glucosidase inhibitors: insight into the probable binding mode. |
| AID1464406 | Inhibition of recombinant human topoisomerase-2alpha catalytic activity expressed in Saccharomyces cerevisiae JEL1 harboring topoisomerase1 deletion mutant assessed as reduction in supercoiled pBR322 DNA relaxation at 10 uM in presence of spermidine by et | 2017 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 27, Issue:20
| Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase IIα. |
| AID1464409 | Inhibition of 3 nM recombinant human topoisomerase-2alpha catalytic activity expressed in Saccharomyces cerevisiae JEL1 harboring topoisomerase1 deletion mutant assessed as reduction in supercoiled pBR322 DNA relaxation at 10 uM after 4 mins by ethidium b | 2017 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 27, Issue:20
| Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase IIα. |
| AID1478625 | Antiproliferative activity against human K562 cells after 48 hrs by CCK8 assay | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Synthesis of xanthone derivatives and studies on the inhibition against cancer cells growth and synergistic combinations of them. |
| AID1474808 | Antibacterial activity against Staphylococcus aureus NBRC 100910 after overnight incubation by microdilution method | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| Syntheses of benzophenone-xanthone hybrid polyketides and their antibacterial activities. |
| AID615825 | Inhibition of yeast alpha-glucosidase using PNP glycoside as substrate after 30 mins by spectrophotometry | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
| Toward potent α-glucosidase inhibitors based on xanthones: a closer look into the structure-activity correlations. |
| AID1478626 | Antiproliferative activity against human COLO320 cells after 48 hrs by CCK8 assay | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Synthesis of xanthone derivatives and studies on the inhibition against cancer cells growth and synergistic combinations of them. |
| AID657725 | Antibacterial activity against Streptococcus pyogenes ATCC 700294 after 20 to 22 hrs by broth microdilution method | 2012 | Bioorganic & medicinal chemistry, May-15, Volume: 20, Issue:10
| An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization. |
| AID1474810 | Antibacterial activity against Klebsiella pneumoniae NBRC 14940 after overnight incubation by microdilution method | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| Syntheses of benzophenone-xanthone hybrid polyketides and their antibacterial activities. |
| AID657723 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 20 to 22 hrs by broth microdilution method | 2012 | Bioorganic & medicinal chemistry, May-15, Volume: 20, Issue:10
| An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization. |
| AID1478623 | Antiproliferative activity against human MCF7 cells after 48 hrs by CCK8 assay | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Synthesis of xanthone derivatives and studies on the inhibition against cancer cells growth and synergistic combinations of them. |
| AID657727 | Antibacterial activity against Haemophilus influenzae ATCC 49247 after 20 to 22 hrs by broth microdilution method | 2012 | Bioorganic & medicinal chemistry, May-15, Volume: 20, Issue:10
| An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization. |
| AID289301 | Growth inhibition of human MCF7 cells | 2007 | Bioorganic & medicinal chemistry, Sep-15, Volume: 15, Issue:18
| Dihydroxyxanthones prenylated derivatives: synthesis, structure elucidation, and growth inhibitory activity on human tumor cell lines with improvement of selectivity for MCF-7. |
| AID1464400 | Poison activity at recombinant human topoisomerase-2alpha expressed in Saccharomyces cerevisiae JEL1 harboring topoisomerase1 deletion mutant assessed as enzyme-mediated supercoiled pBR322 cleavable complex formation at 2.5 to 100 uM after 6 mins by ethid | 2017 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 27, Issue:20
| Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase IIα. |
| AID1597640 | Cytotoxicity against human L02 cells assessed as effect on cell survival at 0.625 to 2.5 uM incubated for 44 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Sep-01, Volume: 177 | Design and synthesis of novel xanthone-triazole derivatives as potential antidiabetic agents: α-Glucosidase inhibition and glucose uptake promotion. |
| AID657729 | Cytotoxicity against human HepG2 cells assessed as NADH level after overnight incubation by MTS assay | 2012 | Bioorganic & medicinal chemistry, May-15, Volume: 20, Issue:10
| An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization. |
| AID661915 | Inhibition of wild type H1N1 swine influenza virus neuraminidase using 4-MU-NANA as substrate by fluorescence assay | 2012 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11
| Xanthones from Polygala karensium inhibit neuraminidases from influenza A viruses. |
| AID1464403 | Inhibition of 3 nM recombinant human topoisomerase-2alpha catalytic activity expressed in Saccharomyces cerevisiae JEL1 harboring topoisomerase1 deletion mutant assessed as reduction in supercoiled pBR322 DNA relaxation after 4 mins by ethidium bromide st | 2017 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 27, Issue:20
| Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase IIα. |
| AID661914 | Inhibition of Influenza A virus H9N2 neuraminidase using 4-MU-NANA as substrate by fluorescence assay | 2012 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11
| Xanthones from Polygala karensium inhibit neuraminidases from influenza A viruses. |
| AID1275955 | Inhibition of yeast alpha-glucosidase using PNP glycoside as substrate preincubated for 30 mins followed by substrate addition measured for 60 secs by spectrophotometric analysis | 2016 | Bioorganic & medicinal chemistry, Apr-01, Volume: 24, Issue:7
| Synthesis of 3-acyloxyxanthone derivatives as α-glucosidase inhibitors: A further insight into the 3-substituents' effect. |
| AID657728 | Antibacterial activity against Escherichia coli ATCC 25922 after 20 to 22 hrs by broth microdilution method | 2012 | Bioorganic & medicinal chemistry, May-15, Volume: 20, Issue:10
| An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization. |
| AID1478624 | Antiproliferative activity against human HepG2 cells after 48 hrs by CCK8 assay | 2017 | European journal of medicinal chemistry, Jun-16, Volume: 133 | Synthesis of xanthone derivatives and studies on the inhibition against cancer cells growth and synergistic combinations of them. |
| AID1357473 | Growth inhibition of human MDA-MB-231 cells after 24 hrs by MTT assay | 2018 | European journal of medicinal chemistry, May-10, Volume: 151 | Incorporation of nitric oxide donor into 1,3-dioxyxanthones leads to synergistic anticancer activity. |
| AID1474809 | Antibacterial activity against Bacillus subtilis NBRC 13719 after overnight incubation by microdilution method | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| Syntheses of benzophenone-xanthone hybrid polyketides and their antibacterial activities. |
| AID661912 | Selectivity ratio of IC50 for wild type H1N1 swine influenza virus neuraminidase to IC50 for oseltamivir-resistant H1N1 swine influenza virus neuraminidase H274Y mutant | 2012 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11
| Xanthones from Polygala karensium inhibit neuraminidases from influenza A viruses. |
| AID661913 | Inhibition of Influenza A virus H1N1 neuraminidase using 4-MU-NANA as substrate by fluorescence assay | 2012 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11
| Xanthones from Polygala karensium inhibit neuraminidases from influenza A viruses. |
| AID289304 | Growth inhibition of human UACC62 cells | 2007 | Bioorganic & medicinal chemistry, Sep-15, Volume: 15, Issue:18
| Dihydroxyxanthones prenylated derivatives: synthesis, structure elucidation, and growth inhibitory activity on human tumor cell lines with improvement of selectivity for MCF-7. |
| AID657730 | Cytotoxicity against human Jurkat T cells assessed as NADH level after overnight incubation by MTS assay | 2012 | Bioorganic & medicinal chemistry, May-15, Volume: 20, Issue:10
| An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization. |
| AID289302 | Growth inhibition of human NCI-H460 cells | 2007 | Bioorganic & medicinal chemistry, Sep-15, Volume: 15, Issue:18
| Dihydroxyxanthones prenylated derivatives: synthesis, structure elucidation, and growth inhibitory activity on human tumor cell lines with improvement of selectivity for MCF-7. |
| AID657724 | Antibacterial activity against Streptococcus pneumoniae ATCC 49619 after 20 to 22 hrs by broth microdilution method | 2012 | Bioorganic & medicinal chemistry, May-15, Volume: 20, Issue:10
| An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization. |
| AID1474811 | Antibacterial activity against Escherichia coli NBRC 102203 after overnight incubation by microdilution method | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| Syntheses of benzophenone-xanthone hybrid polyketides and their antibacterial activities. |
| AID1464408 | Inhibition of 150 nM recombinant human topoisomerase-2alpha catalytic activity expressed in Saccharomyces cerevisiae JEL1 harboring topoisomerase1 deletion mutant assessed as reduction in supercoiled pBR322 DNA relaxation at 10 uM after 4 mins by ethidium | 2017 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 27, Issue:20
| Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase IIα. |
| AID661916 | Inhibition of oseltamivir-resistant H1N1 swine influenza virus neuraminidase H274Y mutant using 4-MU-NANA as substrate by fluorescence assay | 2012 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11
| Xanthones from Polygala karensium inhibit neuraminidases from influenza A viruses. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |