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2-hydroxy-dATP hydrolase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: 2-hydroxy-dATP + H2O = 2-hydroxy-dAMP + H+ + diphosphate. [PMID:11139615, RHEA:31583]

2-Hydroxy-dATP hydrolase activity is a catalytic activity that specifically hydrolyzes 2-hydroxy-dATP, a modified deoxyadenosine triphosphate. This enzyme plays a crucial role in maintaining the fidelity of DNA replication by removing 2-hydroxy-dATP, which is a mutagenic nucleotide analog. 2-Hydroxy-dATP can arise from oxidative stress or other cellular processes, and its presence can lead to misincorporation into DNA, resulting in mutations and genomic instability. 2-Hydroxy-dATP hydrolase activity ensures that this mutagenic nucleotide is removed from the cellular pool, preventing its incorporation into DNA and preserving the integrity of the genome. The enzyme utilizes a hydrolytic mechanism, breaking the phosphodiester bond between the phosphate group and the ribose moiety of 2-hydroxy-dATP, releasing 2-hydroxy-dAMP and inorganic pyrophosphate. This activity is essential for maintaining genomic stability and preventing the accumulation of mutations. It is part of a larger network of DNA repair and nucleotide metabolism pathways that collectively safeguard the genetic information within cells.'
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Proteins (1)

ProteinDefinitionTaxonomy
7,8-dihydro-8-oxoguanine triphosphataseAn oxidized purine nucleoside triphosphate hydrolase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P36639]Homo sapiens (human)

Compounds (19)

CompoundDefinitionClassesRoles
kinetincytokinin : A phytohormone that promote cell division, or cytokinesis, in plant roots and shoots.

kinetin : A member of the class of 6-aminopurines that is adenine carrying a (furan-2-ylmethyl) substituent at the exocyclic amino group.

Kinetin: A furanyl adenine found in PLANTS and FUNGI. It has plant growth regulation effects.
6-aminopurines;
furans
cytokinin;
geroprotector
7-azaindolepyrrolopyridine
2-aminobenzimidazole2-aminobenzimidazole : A member of the class of benzimidazoles that is benzimidazole in which the hydrogen at position 2 is replaced by an amino group.

2-aminobenzimidazole: metabolite of benomyl; RN given refers to parent cpd
benzimidazolesmarine xenobiotic metabolite
imiquimodimiquimod : An imidazoquinoline fused [4,5-c] carrying isobutyl and amino substituents at N-1 and C-4 respectively. A prescription medication, it acts as an immune response modifier and is used to treat genital warts, superficial basal cell carcinoma, and actinic keratosis.

Imiquimod: A topically-applied aminoquinoline immune modulator that induces interferon production. It is used in the treatment of external genital and perianal warts, superficial CARCINOMA, BASAL CELL; and ACTINIC KERATOSIS.
imidazoquinolineantineoplastic agent;
interferon inducer
1h-imidazo(4,5-b)pyridine1H-imidazo(4,5-b)pyridine: structure given in first source

4-azabenzimidazole : The [4,5-b]-fused isomer of imidazopyridine.
imidazopyridine
resiquimodS 28463: structure given in first sourceimidazoquinoline
4-methyl-2-quinazolinamine4-methyl-2-quinazolinamine: from Streptomyces of TCM plant; structure in first source
8-deoxygartanin8-deoxygartanin: a butyrylcholinesterase inhibitor; isolated from Garcinia mangostana; structure in first sourcexanthones
zeatinZeatin: An aminopurine factor in plant extracts that induces cell division. (Grant & Hackh's Chemical Dict, 5th ed)zeatinplant metabolite
mangostinalpha-mangostin : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities.

mangostin: xanthone from rind of Garcinia mangostana Linn. fruit
aromatic ether;
phenols;
xanthones
antimicrobial agent;
antineoplastic agent;
antioxidant;
plant metabolite
norathyriolnorathyriol : A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 3, 6 and 7. Isolated from Garcinia mangostana and Maclura pomifera, it exhibits inhibitory activity against protein kinase C.

norathyriol: from Gentinanaceae; has vasorelaxing action on rat thoracic aorta; structure given in first source
polyphenol;
xanthones
antineoplastic agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
plant metabolite
gamma-mangostingamma-mangostin : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3, 6 and 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antitumour activity.phenols;
xanthones
antineoplastic agent;
plant metabolite;
protein kinase inhibitor
1,3,7-trihydroxy-2-(3-methylbut-2-enyl)-xanthone1,3,7-trihydroxy-2-(3-methylbut-2-enyl)-xanthone: from stems of Kielmeyera coriacea; structure in first source
sch 51344SCH 51344: inhibits ras transformation; structure given in first source

SCH51344 : A pyrazoloquinoline that is 6-methoxy-3-methyl-1H-pyrazolo[3,4-b]quinoline bearing an additional 2-[(2-hydroxyethoxy)ethyl]amino substituent at position 4
aromatic amine;
aromatic ether;
primary alcohol;
pyrazoloquinoline;
secondary amino compound
antineoplastic agent
3,4,5,6-tetrahydroxyxanthone
sm360320SM360320: Proc Natl Acad Sci U S A 2006 Feb 7;103(6):1828-33
3-isomangostin3-isomangostin: structure in first sourcexanthones
garcinone cgarcinone C: an acetylcholinesterase inhibitor; isolated from Garcinia mangostana; structure in first sourcexanthones
ent-crizotinibent-crizotinib : A 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine that is the (S)-enantiomer of crizotinib.3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine