8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
Definition
Target type: molecularfunction
Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA. [PMID:17804481, PMID:7782328, PMID:7859359, RHEA:31575]
8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity catalyzes the hydrolysis of 8-oxo-7,8-dihydrodeoxyguanosine triphosphate (8-oxo-dGTP) to 8-oxo-7,8-dihydrodeoxyguanosine monophosphate (8-oxo-dGMP) and pyrophosphate. This activity is crucial for preventing the incorporation of the oxidized nucleotide 8-oxo-dGTP into DNA during replication, which can lead to mutations and genomic instability. The enzyme specifically recognizes and removes 8-oxo-dGTP, a highly mutagenic form of dGTP, from the nucleotide pool, thereby preventing its incorporation into DNA by DNA polymerases. 8-oxo-dGTP pyrophosphatase plays a significant role in maintaining genomic integrity by removing this mutagenic nucleotide and preventing the accumulation of mutations that could lead to various diseases, including cancer.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| 7,8-dihydro-8-oxoguanine triphosphatase | An oxidized purine nucleoside triphosphate hydrolase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P36639] | Homo sapiens (human) |
Compounds (19)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| kinetin | cytokinin : A phytohormone that promote cell division, or cytokinesis, in plant roots and shoots. kinetin : A member of the class of 6-aminopurines that is adenine carrying a (furan-2-ylmethyl) substituent at the exocyclic amino group. Kinetin: A furanyl adenine found in PLANTS and FUNGI. It has plant growth regulation effects. | 6-aminopurines; furans | cytokinin; geroprotector |
| 7-azaindole | pyrrolopyridine | ||
| 2-aminobenzimidazole | 2-aminobenzimidazole : A member of the class of benzimidazoles that is benzimidazole in which the hydrogen at position 2 is replaced by an amino group. 2-aminobenzimidazole: metabolite of benomyl; RN given refers to parent cpd | benzimidazoles | marine xenobiotic metabolite |
| imiquimod | imiquimod : An imidazoquinoline fused [4,5-c] carrying isobutyl and amino substituents at N-1 and C-4 respectively. A prescription medication, it acts as an immune response modifier and is used to treat genital warts, superficial basal cell carcinoma, and actinic keratosis. Imiquimod: A topically-applied aminoquinoline immune modulator that induces interferon production. It is used in the treatment of external genital and perianal warts, superficial CARCINOMA, BASAL CELL; and ACTINIC KERATOSIS. | imidazoquinoline | antineoplastic agent; interferon inducer |
| 1h-imidazo(4,5-b)pyridine | 1H-imidazo(4,5-b)pyridine: structure given in first source 4-azabenzimidazole : The [4,5-b]-fused isomer of imidazopyridine. | imidazopyridine | |
| resiquimod | S 28463: structure given in first source | imidazoquinoline | |
| 4-methyl-2-quinazolinamine | 4-methyl-2-quinazolinamine: from Streptomyces of TCM plant; structure in first source | ||
| 8-deoxygartanin | 8-deoxygartanin: a butyrylcholinesterase inhibitor; isolated from Garcinia mangostana; structure in first source | xanthones | |
| zeatin | Zeatin: An aminopurine factor in plant extracts that induces cell division. (Grant & Hackh's Chemical Dict, 5th ed) | zeatin | plant metabolite |
| mangostin | alpha-mangostin : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities. mangostin: xanthone from rind of Garcinia mangostana Linn. fruit | aromatic ether; phenols; xanthones | antimicrobial agent; antineoplastic agent; antioxidant; plant metabolite |
| norathyriol | norathyriol : A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 3, 6 and 7. Isolated from Garcinia mangostana and Maclura pomifera, it exhibits inhibitory activity against protein kinase C. norathyriol: from Gentinanaceae; has vasorelaxing action on rat thoracic aorta; structure given in first source | polyphenol; xanthones | antineoplastic agent; EC 2.7.11.13 (protein kinase C) inhibitor; plant metabolite |
| gamma-mangostin | gamma-mangostin : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3, 6 and 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antitumour activity. | phenols; xanthones | antineoplastic agent; plant metabolite; protein kinase inhibitor |
| 1,3,7-trihydroxy-2-(3-methylbut-2-enyl)-xanthone | 1,3,7-trihydroxy-2-(3-methylbut-2-enyl)-xanthone: from stems of Kielmeyera coriacea; structure in first source | ||
| sch 51344 | SCH 51344: inhibits ras transformation; structure given in first source SCH51344 : A pyrazoloquinoline that is 6-methoxy-3-methyl-1H-pyrazolo[3,4-b]quinoline bearing an additional 2-[(2-hydroxyethoxy)ethyl]amino substituent at position 4 | aromatic amine; aromatic ether; primary alcohol; pyrazoloquinoline; secondary amino compound | antineoplastic agent |
| 3,4,5,6-tetrahydroxyxanthone | |||
| sm360320 | SM360320: Proc Natl Acad Sci U S A 2006 Feb 7;103(6):1828-33 | ||
| 3-isomangostin | 3-isomangostin: structure in first source | xanthones | |
| garcinone c | garcinone C: an acetylcholinesterase inhibitor; isolated from Garcinia mangostana; structure in first source | xanthones | |
| ent-crizotinib | ent-crizotinib : A 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine that is the (S)-enantiomer of crizotinib. | 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine |