hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Definition
Target type: molecularfunction
Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. [GOC:jl]
Hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, refers to a type of enzymatic activity that breaks down the chemical bonds within acid anhydrides specifically those involving phosphorus-containing anhydrides. These enzymes catalyze the hydrolysis of these anhydrides, adding a water molecule to break the bond and forming two products. These enzymes play crucial roles in various biological processes, including:
* **Energy Metabolism:** They are essential in the breakdown of ATP (adenosine triphosphate), the primary energy currency of cells. By cleaving the phosphate bonds in ATP, these hydrolases release energy for cellular processes.
* **Signal Transduction:** Hydrolases involved in phospholipid hydrolysis play a critical role in signal transduction pathways. They generate signaling molecules like diacylglycerol (DAG) and inositol triphosphate (IP3), which regulate cellular functions.
* **DNA and RNA Metabolism:** Hydrolases participate in the processing and degradation of DNA and RNA. They cleave phosphate bonds within these nucleic acids, enabling their replication, transcription, and repair.
* **Cellular Regulation:** These enzymes are involved in a wide range of cellular processes, including protein phosphorylation and dephosphorylation, which regulate protein activity and signaling pathways.
* **Nutrient Utilization:** Hydrolases facilitate the breakdown of phospholipids, which are crucial for cell structure and nutrient transport. They release fatty acids, glycerol, and other molecules that can be further utilized for energy or biosynthesis.'
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Proteins (2)
| Protein | Definition | Taxonomy |
|---|---|---|
| ATP-dependent DNA helicase DinG | An ATP-dependent DNA helicase DinG that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P27296] | Escherichia coli K-12 |
| 7,8-dihydro-8-oxoguanine triphosphatase | An oxidized purine nucleoside triphosphate hydrolase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P36639] | Homo sapiens (human) |
Compounds (20)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| kinetin | cytokinin : A phytohormone that promote cell division, or cytokinesis, in plant roots and shoots. kinetin : A member of the class of 6-aminopurines that is adenine carrying a (furan-2-ylmethyl) substituent at the exocyclic amino group. Kinetin: A furanyl adenine found in PLANTS and FUNGI. It has plant growth regulation effects. | 6-aminopurines; furans | cytokinin; geroprotector |
| 7-azaindole | pyrrolopyridine | ||
| 2-aminobenzimidazole | 2-aminobenzimidazole : A member of the class of benzimidazoles that is benzimidazole in which the hydrogen at position 2 is replaced by an amino group. 2-aminobenzimidazole: metabolite of benomyl; RN given refers to parent cpd | benzimidazoles | marine xenobiotic metabolite |
| imiquimod | imiquimod : An imidazoquinoline fused [4,5-c] carrying isobutyl and amino substituents at N-1 and C-4 respectively. A prescription medication, it acts as an immune response modifier and is used to treat genital warts, superficial basal cell carcinoma, and actinic keratosis. Imiquimod: A topically-applied aminoquinoline immune modulator that induces interferon production. It is used in the treatment of external genital and perianal warts, superficial CARCINOMA, BASAL CELL; and ACTINIC KERATOSIS. | imidazoquinoline | antineoplastic agent; interferon inducer |
| 1h-imidazo(4,5-b)pyridine | 1H-imidazo(4,5-b)pyridine: structure given in first source 4-azabenzimidazole : The [4,5-b]-fused isomer of imidazopyridine. | imidazopyridine | |
| resiquimod | S 28463: structure given in first source | imidazoquinoline | |
| 4-methyl-2-quinazolinamine | 4-methyl-2-quinazolinamine: from Streptomyces of TCM plant; structure in first source | ||
| 8-deoxygartanin | 8-deoxygartanin: a butyrylcholinesterase inhibitor; isolated from Garcinia mangostana; structure in first source | xanthones | |
| Telomestatin | 1,3-oxazoles | ||
| zeatin | Zeatin: An aminopurine factor in plant extracts that induces cell division. (Grant & Hackh's Chemical Dict, 5th ed) | zeatin | plant metabolite |
| mangostin | alpha-mangostin : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities. mangostin: xanthone from rind of Garcinia mangostana Linn. fruit | aromatic ether; phenols; xanthones | antimicrobial agent; antineoplastic agent; antioxidant; plant metabolite |
| norathyriol | norathyriol : A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 3, 6 and 7. Isolated from Garcinia mangostana and Maclura pomifera, it exhibits inhibitory activity against protein kinase C. norathyriol: from Gentinanaceae; has vasorelaxing action on rat thoracic aorta; structure given in first source | polyphenol; xanthones | antineoplastic agent; EC 2.7.11.13 (protein kinase C) inhibitor; plant metabolite |
| gamma-mangostin | gamma-mangostin : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3, 6 and 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antitumour activity. | phenols; xanthones | antineoplastic agent; plant metabolite; protein kinase inhibitor |
| 1,3,7-trihydroxy-2-(3-methylbut-2-enyl)-xanthone | 1,3,7-trihydroxy-2-(3-methylbut-2-enyl)-xanthone: from stems of Kielmeyera coriacea; structure in first source | ||
| sch 51344 | SCH 51344: inhibits ras transformation; structure given in first source SCH51344 : A pyrazoloquinoline that is 6-methoxy-3-methyl-1H-pyrazolo[3,4-b]quinoline bearing an additional 2-[(2-hydroxyethoxy)ethyl]amino substituent at position 4 | aromatic amine; aromatic ether; primary alcohol; pyrazoloquinoline; secondary amino compound | antineoplastic agent |
| 3,4,5,6-tetrahydroxyxanthone | |||
| sm360320 | SM360320: Proc Natl Acad Sci U S A 2006 Feb 7;103(6):1828-33 | ||
| 3-isomangostin | 3-isomangostin: structure in first source | xanthones | |
| garcinone c | garcinone C: an acetylcholinesterase inhibitor; isolated from Garcinia mangostana; structure in first source | xanthones | |
| ent-crizotinib | ent-crizotinib : A 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine that is the (S)-enantiomer of crizotinib. | 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine |