Page last updated: 2024-12-11
geiparvarin
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
geiparvarin: from Geijera parviflora; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Related Flora
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Geijera | genus | [no description available] | Rutaceae | A plant family in the order Sapindales that grows in warmer regions and has conspicuous flowers.[MeSH] |
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 5910585 |
| CHEMBL ID | 56918 |
| SCHEMBL ID | 2532495 |
| MeSH ID | M0162982 |
Synonyms (15)
| Synonym |
|---|
| nsc 142227 |
| 2h-1-benzopyran-2-one, 7-((3-(4,5-dihydro-5,5-dimethyl-4-oxo-2-furanyl)-2-butenyl)oxy)-, (e)- |
| o0m5jb2l95 , |
| unii-o0m5jb2l95 |
| mls002920544 , |
| 36413-91-9 |
| geiparvarin |
| nsc-142227 |
| CHEMBL56918 |
| 7-[(e)-3-(5,5-dimethyl-4-oxofuran-2-yl)but-2-enoxy]chromen-2-one |
| 7-(((2e)-3-(5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)but-2-en-1-yl)oxy)-2h-chromen-2-one |
| bdbm50421583 |
| SCHEMBL2532495 |
| Q5530160 |
| DTXSID201026772 |
Research Excerpts
Overview
Geiparvarin is an antiproliferative compound isolated from the leaves of Geijera parviflora. It may represent a new drug which targets tubulin.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Geiparvarin (GN) is a natural compound isolated from the leaves of Geijera parviflora and exhibits anticancer activity. " | ( Geiparvarin Inhibits the Progression of Osteosarcoma by Down-regulating COX2 Expression. Chen, S; Du, J; Huang, P; Wang, B; Zhang, Z; Zou, H, 2023) | 3.8 |
| "Geiparvarin is an antiproliferative compound whose mechanism of action has not yet been identified. " | ( Interaction of geiparvarin and related compounds with purified microtubular protein. Bisi, A; Bocca, C; Da Re, P; Gabriel, L; Gadoni, E; Miglietta, A; Rampa, A; Valenti, P, 1996) | 2.09 |
| "Geiparvarin is an antiproliferative compound isolated from the leaves of Geijera parviflora, and may represent a new drug which targets tubulin. " | ( Antimicrotubular and cytotoxic activity of geiparvarin analogues, alone and in combination with paclitaxel. Bisi, A; Bocca, C; Gabriel, L; Miglietta, A; Rampa, A; Valenti, P, 2001) | 2.02 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Protein Targets (8)
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 0.8300 | 0.0002 | 1.1043 | 9.9000 | AID729559 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 9.7500 | 0.0000 | 1.3726 | 10.0000 | AID729563 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 100.0000 | 0.0000 | 0.7236 | 9.9200 | AID729562 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 (µMol) | 26.9154 | 0.0000 | 2.3789 | 9.7700 | AID126361 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 (µMol) | 0.1445 | 0.0000 | 1.8914 | 9.5700 | AID127195 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 7.8200 | 0.0002 | 1.3737 | 9.9000 | AID729561 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 0.6000 | 0.0001 | 0.7874 | 9.9000 | AID729560 |
| Carbonic anhydrase 13 | Homo sapiens (human) | Ki | 9.6200 | 0.0003 | 1.2309 | 9.8000 | AID729558 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
Biological Processes (31)
Molecular Functions (13)
Ceullar Components (17)
Bioassays (44)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID665498 | Induction of apoptosis in human A549 cells assessed as viable cells at 1 uM after 48 hrs by annexinV/propidium iodide staining-based flow cytometric analysis ( Rvb = 95.96%) | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry. |
| AID665494 | Cytotoxicity against human QGY7701 cells by after 48 hrs by MTT assay | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry. |
| AID729563 | Inhibition of human carbonic anhydrase 1 preincubated for 6 hrs by CO2 hydration stopped-flow assay | 2013 | Bioorganic & medicinal chemistry, Mar-15, Volume: 21, Issue:6 | Natural product coumarins that inhibit human carbonic anhydrases. |
| AID729559 | Inhibition of human carbonic anhydrase 12 preincubated for 6 hrs by CO2 hydration stopped-flow assay | 2013 | Bioorganic & medicinal chemistry, Mar-15, Volume: 21, Issue:6 | Natural product coumarins that inhibit human carbonic anhydrases. |
| AID225074 | Inhibitory effect on the proliferation of murine mammary carcinoma FM3A cells | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10 | Geiparvarin analogues. 3. Synthesis and cytostatic activity of 3(2H)-furanone and 4,5-dihydro-3(2H)-furanone congeners of geiparvarin, containing a geraniol-like fragment in the side chain. |
| AID665511 | Induction of apoptosis in human A549 cells assessed as early apoptotic cells at 8 uM after 48 hrs by annexinV/propidium iodide staining-based flow cytometric analysis ( Rvb = 0.15%) | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry. |
| AID729560 | Inhibition of human carbonic anhydrase 9 preincubated for 6 hrs by CO2 hydration stopped-flow assay | 2013 | Bioorganic & medicinal chemistry, Mar-15, Volume: 21, Issue:6 | Natural product coumarins that inhibit human carbonic anhydrases. |
| AID665499 | Induction of apoptosis in human A549 cells assessed as early apoptotic cells at 1 uM after 48 hrs by annexinV/propidium iodide staining-based flow cytometric analysis ( Rvb = 0.15%) | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry. |
| AID665495 | Cytotoxicity against human SW480 cells by after 48 hrs by MTT assay | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry. |
| AID47468 | Ability to inhibit human CEM tumor cell proliferation by 50% | 1989 | Journal of medicinal chemistry, Feb, Volume: 32, Issue:2 | Synthesis and cytostatic activity of geiparvarin analogues. |
| AID665491 | Cytotoxicity against human L02 cells by after 48 hrs by MTT assay | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry. |
| AID665509 | Induction of apoptosis in human A549 cells assessed as viable cells at 4 uM after 48 hrs by annexinV/propidium iodide staining-based flow cytometric analysis (Rvb = 3.72%) | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry. |
| AID221971 | Inhibitory effect on the proliferation of human T-lymphocyte MT-4 cells. | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10 | Geiparvarin analogues. 3. Synthesis and cytostatic activity of 3(2H)-furanone and 4,5-dihydro-3(2H)-furanone congeners of geiparvarin, containing a geraniol-like fragment in the side chain. |
| AID665503 | Induction of apoptosis in human A549 cells assessed as early apoptotic cells at 2 uM after 48 hrs by annexinV/propidium iodide staining-based flow cytometric analysis ( Rvb = 0.15%) | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry. |
| AID125492 | Ability to inhibit human Molt/4F tumor cell proliferation by 50% | 1989 | Journal of medicinal chemistry, Feb, Volume: 32, Issue:2 | Synthesis and cytostatic activity of geiparvarin analogues. |
| AID729558 | Inhibition of human carbonic anhydrase 13 preincubated for 6 hrs by CO2 hydration stopped-flow assay | 2013 | Bioorganic & medicinal chemistry, Mar-15, Volume: 21, Issue:6 | Natural product coumarins that inhibit human carbonic anhydrases. |
| AID665500 | Induction of apoptosis in human A549 cells assessed as late apoptotic cells at 1 uM after 48 hrs by annexinV/propidium iodide staining-based flow cytometric analysis (Rvb = 0.16%) | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry. |
| AID665502 | Induction of apoptosis in human A549 cells assessed as viable cells at 2 uM after 48 hrs by annexinV/propidium iodide staining-based flow cytometric analysis ( Rvb = 95.96%) | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry. |
| AID665504 | Induction of apoptosis in human A549 cells assessed as late apoptotic cells at 2 uM after 48 hrs by annexinV/propidium iodide staining-based flow cytometric analysis (Rvb = 0.16%) | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry. |
| AID729562 | Inhibition of human carbonic anhydrase 2 preincubated for 6 hrs by CO2 hydration stopped-flow assay | 2013 | Bioorganic & medicinal chemistry, Mar-15, Volume: 21, Issue:6 | Natural product coumarins that inhibit human carbonic anhydrases. |
| AID165914 | Ability to inhibit human Raji tumor cell proliferation by 50% | 1989 | Journal of medicinal chemistry, Feb, Volume: 32, Issue:2 | Synthesis and cytostatic activity of geiparvarin analogues. |
| AID15873 | Partition coefficient of compound was determined | 2002 | Bioorganic & medicinal chemistry letters, Dec-16, Volume: 12, Issue:24 | Natural and synthetic geiparvarins are strong and selective MAO-B inhibitors. Synthesis and SAR studies. |
| AID665497 | Cytotoxicity against human MDA-MB-231 cells by after 48 hrs by MTT assay | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry. |
| AID221801 | Inhibitory effect on the proliferation of human B-lymphoblast Raji cells. | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10 | Geiparvarin analogues. 3. Synthesis and cytostatic activity of 3(2H)-furanone and 4,5-dihydro-3(2H)-furanone congeners of geiparvarin, containing a geraniol-like fragment in the side chain. |
| AID72034 | Ability to inhibit murine FM3A tumor cell proliferation by 50% | 1989 | Journal of medicinal chemistry, Feb, Volume: 32, Issue:2 | Synthesis and cytostatic activity of geiparvarin analogues. |
| AID79135 | Ability to inhibit human H9 tumor cell proliferation by 50% | 1989 | Journal of medicinal chemistry, Feb, Volume: 32, Issue:2 | Synthesis and cytostatic activity of geiparvarin analogues. |
| AID665501 | Induction of apoptosis in human A549 cells assessed as viable cells at 1 uM after 48 hrs by annexinV/propidium iodide staining-based flow cytometric analysis (Rvb = 3.72%) | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry. |
| AID665512 | Induction of apoptosis in human A549 cells assessed as late apoptotic cells at 8 uM after 48 hrs by annexinV/propidium iodide staining-based flow cytometric analysis (Rvb = 0.16%) | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry. |
| AID225051 | Inhibitory effect on the proliferation of murine leukemia L1210 cells. | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10 | Geiparvarin analogues. 3. Synthesis and cytostatic activity of 3(2H)-furanone and 4,5-dihydro-3(2H)-furanone congeners of geiparvarin, containing a geraniol-like fragment in the side chain. |
| AID98701 | Ability to inhibit murine L1210 tumor cell proliferation by 50% | 1989 | Journal of medicinal chemistry, Feb, Volume: 32, Issue:2 | Synthesis and cytostatic activity of geiparvarin analogues. |
| AID665508 | Induction of apoptosis in human A549 cells assessed as late apoptotic cells at 4 uM after 48 hrs by annexinV/propidium iodide staining-based flow cytometric analysis (Rvb = 0.16%) | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry. |
| AID665513 | Induction of apoptosis in human A549 cells assessed as viable cells at 8 uM after 48 hrs by annexinV/propidium iodide staining-based flow cytometric analysis (Rvb = 3.72%) | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry. |
| AID127195 | Inhibitory potency against Monoamine oxidase B | 2002 | Bioorganic & medicinal chemistry letters, Dec-16, Volume: 12, Issue:24 | Natural and synthetic geiparvarins are strong and selective MAO-B inhibitors. Synthesis and SAR studies. |
| AID665510 | Induction of apoptosis in human A549 cells assessed as viable cells at 8 uM after 48 hrs by annexinV/propidium iodide staining-based flow cytometric analysis ( Rvb = 95.96%) | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry. |
| AID210309 | Inhibitory effect on the proliferation of T-lymphoblast molt/4F cells. | 1992 | Journal of medicinal chemistry, May-15, Volume: 35, Issue:10 | Geiparvarin analogues. 3. Synthesis and cytostatic activity of 3(2H)-furanone and 4,5-dihydro-3(2H)-furanone congeners of geiparvarin, containing a geraniol-like fragment in the side chain. |
| AID665496 | Cytotoxicity against human SGC7901 cells by after 48 hrs by MTT assay | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry. |
| AID665492 | Cytotoxicity against human A549 cells by after 48 hrs by MTT assay | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry. |
| AID729561 | Inhibition of human carbonic anhydrase 7 preincubated for 6 hrs by CO2 hydration stopped-flow assay | 2013 | Bioorganic & medicinal chemistry, Mar-15, Volume: 21, Issue:6 | Natural product coumarins that inhibit human carbonic anhydrases. |
| AID105737 | Ability to inhibit human MT-4 tumor cell proliferation by 50% | 1989 | Journal of medicinal chemistry, Feb, Volume: 32, Issue:2 | Synthesis and cytostatic activity of geiparvarin analogues. |
| AID665505 | Induction of apoptosis in human A549 cells assessed as viable cells at 2 uM after 48 hrs by annexinV/propidium iodide staining-based flow cytometric analysis (Rvb = 3.72%) | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry. |
| AID665493 | Cytotoxicity against human HeLa cells by after 48 hrs by MTT assay | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry. |
| AID665506 | Induction of apoptosis in human A549 cells assessed as viable cells at 4 uM after 48 hrs by annexinV/propidium iodide staining-based flow cytometric analysis ( Rvb = 95.96%) | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry. |
| AID665507 | Induction of apoptosis in human A549 cells assessed as early apoptotic cells at 4 uM after 48 hrs by annexinV/propidium iodide staining-based flow cytometric analysis ( Rvb = 0.15%) | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry. |
| AID126361 | Inhibitory potency against Monoamine oxidase A | 2002 | Bioorganic & medicinal chemistry letters, Dec-16, Volume: 12, Issue:24 | Natural and synthetic geiparvarins are strong and selective MAO-B inhibitors. Synthesis and SAR studies. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (17)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (5.88) | 18.7374 |
| 1990's | 8 (47.06) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 20.01
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (20.01) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 17 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||