Page last updated: 2024-12-06

n-4-tosylglycine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

N-4-tosylglycine: facilitates insulin release [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID70653
CHEMBL ID287486
SCHEMBL ID760439
MeSH IDM0133267

Synonyms (57)

Synonym
BB 0219377
nsc25821
nsc-25821
1080-44-0
CBDIVE_003168
OPREA1_169137
EU-0000679
n-p-tosylglycine, 97%
CHEMBL287486 ,
STL087629
n-[(4-methylphenyl)sulfonyl]glycine
2-[(4-methylphenyl)sulfonylamino]acetic acid
AKOS001060050
n-p-tosylglycine
HMS1607N08
(toluene-4-sulfonylamino)-acetic acid
bdbm50016567
A801797
2-[(4-methylphenyl)sulfonylamino]ethanoic acid
n-(p-toluenesulfonyl)glycine
n-tosylglycine
tos-gly-oh
T2803
2-{[(4-methylphenyl)sulfonyl]amino}acetic acid
n-4-tosylglycine
glycine, n-((4-methylphenyl)sulfonyl)-
nsc 25821
FT-0633313
BBL022967
tosyl-glycine
2-(4-methylphenylsulfonamido)acetic acid
F0020-0600
AB00275149-04
AM81796
n-(toluene-4-sulfonyl)-glycine
SCHEMBL760439
([(4-methylphenyl)sulfonyl]amino)acetic acid #
n-p-toluenesulfonyl-dl-glycine
glycine, n-p-toluenesulfonyl-
glycine, n-[(4-methylphenyl)sulfonyl]-
DTXSID00148355
mfcd00045898
J-002047
n-[(4-methylphenyl)sulfonyl]glycne
J-523301
SR-01000393622-1
sr-01000393622
tosylglycin
SY033142
Z45658546
CS-0046764
DS-13625
n-(toluene-4-sulfonyl)glycine
NCGC00325861-01
2-(4-methylbenzenesulfonamido)acetic acid
EN300-00514
HY-W053699
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (5)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Carbonic anhydrase 12Homo sapiens (human)IC50 (µMol)8.57000.00571.39908.5700AID1180164
Carbonic anhydrase 1Homo sapiens (human)IC50 (µMol)50.00000.00582.14107.9000AID1180159
Carbonic anhydrase 1Homo sapiens (human)Ki120.10000.00001.372610.0000AID1254397
Carbonic anhydrase 2Homo sapiens (human)IC50 (µMol)3.62300.00021.10608.3000AID1180161
Carbonic anhydrase 2Homo sapiens (human)Ki143.80000.00000.72369.9200AID1254398
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)IC50 (µMol)32.00000.00041.877310.0000AID34970
Carbonic anhydrase 9Homo sapiens (human)IC50 (µMol)0.21700.00030.63029.3900AID1180163
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (17)

Processvia Protein(s)Taxonomy
estrous cycleCarbonic anhydrase 12Homo sapiens (human)
chloride ion homeostasisCarbonic anhydrase 12Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 12Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 1Homo sapiens (human)
morphogenesis of an epitheliumCarbonic anhydrase 2Homo sapiens (human)
positive regulation of synaptic transmission, GABAergicCarbonic anhydrase 2Homo sapiens (human)
positive regulation of cellular pH reductionCarbonic anhydrase 2Homo sapiens (human)
angiotensin-activated signaling pathwayCarbonic anhydrase 2Homo sapiens (human)
regulation of monoatomic anion transportCarbonic anhydrase 2Homo sapiens (human)
secretionCarbonic anhydrase 2Homo sapiens (human)
regulation of intracellular pHCarbonic anhydrase 2Homo sapiens (human)
neuron cellular homeostasisCarbonic anhydrase 2Homo sapiens (human)
positive regulation of dipeptide transmembrane transportCarbonic anhydrase 2Homo sapiens (human)
regulation of chloride transportCarbonic anhydrase 2Homo sapiens (human)
carbon dioxide transportCarbonic anhydrase 2Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 2Homo sapiens (human)
response to hypoxiaCarbonic anhydrase 9Homo sapiens (human)
morphogenesis of an epitheliumCarbonic anhydrase 9Homo sapiens (human)
response to xenobiotic stimulusCarbonic anhydrase 9Homo sapiens (human)
response to testosteroneCarbonic anhydrase 9Homo sapiens (human)
secretionCarbonic anhydrase 9Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 9Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (7)

Processvia Protein(s)Taxonomy
zinc ion bindingCarbonic anhydrase 12Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 12Homo sapiens (human)
arylesterase activityCarbonic anhydrase 1Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 1Homo sapiens (human)
protein bindingCarbonic anhydrase 1Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 1Homo sapiens (human)
hydro-lyase activityCarbonic anhydrase 1Homo sapiens (human)
cyanamide hydratase activityCarbonic anhydrase 1Homo sapiens (human)
arylesterase activityCarbonic anhydrase 2Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 2Homo sapiens (human)
protein bindingCarbonic anhydrase 2Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 2Homo sapiens (human)
cyanamide hydratase activityCarbonic anhydrase 2Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 9Homo sapiens (human)
protein bindingCarbonic anhydrase 9Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 9Homo sapiens (human)
molecular function activator activityCarbonic anhydrase 9Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (11)

Processvia Protein(s)Taxonomy
plasma membraneCarbonic anhydrase 12Homo sapiens (human)
membraneCarbonic anhydrase 12Homo sapiens (human)
basolateral plasma membraneCarbonic anhydrase 12Homo sapiens (human)
apical plasma membraneCarbonic anhydrase 12Homo sapiens (human)
plasma membraneCarbonic anhydrase 12Homo sapiens (human)
cytosolCarbonic anhydrase 1Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 1Homo sapiens (human)
cytoplasmCarbonic anhydrase 2Homo sapiens (human)
cytosolCarbonic anhydrase 2Homo sapiens (human)
plasma membraneCarbonic anhydrase 2Homo sapiens (human)
myelin sheathCarbonic anhydrase 2Homo sapiens (human)
apical part of cellCarbonic anhydrase 2Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 2Homo sapiens (human)
cytoplasmCarbonic anhydrase 2Homo sapiens (human)
plasma membraneCarbonic anhydrase 2Homo sapiens (human)
apical part of cellCarbonic anhydrase 2Homo sapiens (human)
nucleolusCarbonic anhydrase 9Homo sapiens (human)
plasma membraneCarbonic anhydrase 9Homo sapiens (human)
membraneCarbonic anhydrase 9Homo sapiens (human)
basolateral plasma membraneCarbonic anhydrase 9Homo sapiens (human)
microvillus membraneCarbonic anhydrase 9Homo sapiens (human)
plasma membraneCarbonic anhydrase 9Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (11)

Assay IDTitleYearJournalArticle
AID1180163Inhibition of CA-9 (unknown origin) after 15 mins by CO2 hydration assay2014Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
Flow synthesis and biological activity of aryl sulfonamides as selective carbonic anhydrase IX and XII inhibitors.
AID1180161Inhibition of CA-2 (unknown origin) after 15 mins by CO2 hydration assay2014Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
Flow synthesis and biological activity of aryl sulfonamides as selective carbonic anhydrase IX and XII inhibitors.
AID1180160Inhibition of CA-1 (unknown origin) at 10 uM after 15 mins by CO2 hydration assay2014Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
Flow synthesis and biological activity of aryl sulfonamides as selective carbonic anhydrase IX and XII inhibitors.
AID1254397Inhibition of cytosolic carbonic anhydrase 1 esterase activity isolated from human erythrocytes using 4-nitrophenylacetate as substrate measured over 3 mins by spectrophotometric analysis2015Bioorganic & medicinal chemistry, Dec-01, Volume: 23, Issue:23
Carbonic anhydrase inhibitors: Design, synthesis, kinetic, docking and molecular dynamics analysis of novel glycine and phenylalanine sulfonamide derivatives.
AID34970Inhibitory concentration against aldose reductase obtained from rat lens1989Journal of medicinal chemistry, Jan, Volume: 32, Issue:1
N- and 2-substituted N-(phenylsulfonyl)glycines as inhibitors of rat lens aldose reductase.
AID1254398Inhibition of cytosolic carbonic anhydrase 2 esterase activity isolated from human erythrocytes using 4-nitrophenylacetate as substrate measured over 3 mins by spectrophotometric analysis2015Bioorganic & medicinal chemistry, Dec-01, Volume: 23, Issue:23
Carbonic anhydrase inhibitors: Design, synthesis, kinetic, docking and molecular dynamics analysis of novel glycine and phenylalanine sulfonamide derivatives.
AID1180159Inhibition of CA-1 (unknown origin) after 15 mins by CO2 hydration assay2014Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
Flow synthesis and biological activity of aryl sulfonamides as selective carbonic anhydrase IX and XII inhibitors.
AID1254401Competitive inhibition of cytosolic carbonic anhydrase 1 esterase activity isolated from human erythrocytes in presence of 4-nitrophenylacetate2015Bioorganic & medicinal chemistry, Dec-01, Volume: 23, Issue:23
Carbonic anhydrase inhibitors: Design, synthesis, kinetic, docking and molecular dynamics analysis of novel glycine and phenylalanine sulfonamide derivatives.
AID1180164Inhibition of CA-12 (unknown origin) after 15 mins by CO2 hydration assay2014Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
Flow synthesis and biological activity of aryl sulfonamides as selective carbonic anhydrase IX and XII inhibitors.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (33.33)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (66.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.85

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.85 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.80 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.85)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]