dodoneine profile

dodoneine: has hypotensive activity; isolated from Agelanthus dodoneifolius; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Agelanthus	genus	[no description available]	Loranthaceae	The showy mistletoe plant family of the order Santalales, subclass Rosidae, class Magnoliopsida. This includes parasitic tropical plants with haustoria connecting to the hosts. The leaves are opposite and thick. The flowers (4-7) have both calyx and corolla. The fruit is a berry with one seed.[MeSH]

Flora

Rank

Flora Definition

Family

Family Definition

Agelanthus

genus

[no description available]

Loranthaceae

The showy mistletoe plant family of the order Santalales, subclass Rosidae, class Magnoliopsida. This includes parasitic tropical plants with haustoria connecting to the hosts. The leaves are opposite and thick. The flowers (4-7) have both calyx and corolla. The fruit is a berry with one seed.[MeSH]

ID Source	ID
PubMed CID	24762836
CHEMBL ID	250638
MeSH ID	M000599933

ID Source

PubMed CID

24762836

CHEMBL ID

250638

MeSH ID

M000599933

Synonym
CHEMBL250638 ,
bdbm50435890
dodoneine
(2r)-2-[(2s)-2-hydroxy-4-(4-hydroxyphenyl)butyl]-2,3-dihydropyran-6-one

Synonym

CHEMBL250638 ,

bdbm50435890

dodoneine

(2r)-2-[(2s)-2-hydroxy-4-(4-hydroxyphenyl)butyl]-2,3-dihydropyran-6-one

Protein Targets (5)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Carbonic anhydrase 1	Homo sapiens (human)	Ki	5.4800	0.0000	1.3726	10.0000	AID753986
Carbonic anhydrase 3	Homo sapiens (human)	Ki	10.3500	0.0002	2.0102	10.0000	AID753982
Carbonic anhydrase 4	Homo sapiens (human)	Ki	9.6100	0.0002	1.9720	9.9200	AID753980
Carbonic anhydrase 13	Mus musculus (house mouse)	Ki	9.2700	0.0002	1.3974	9.9000	AID753967
Carbonic anhydrase 14	Homo sapiens (human)	Ki	9.3400	0.0002	1.5099	9.9000	AID753965
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein

Taxonomy

Measurement

Average

Min (ref.)

Avg (ref.)

Max (ref.)

Bioassay(s)

Carbonic anhydrase 1

Homo sapiens (human)

5.4800

0.0000

1.3726

10.0000

AID753986

Carbonic anhydrase 3

Homo sapiens (human)

10.3500

0.0002

2.0102

10.0000

Process	via Protein(s)	Taxonomy
one-carbon metabolic process	Carbonic anhydrase 1	Homo sapiens (human)
response to bacterium	Carbonic anhydrase 3	Homo sapiens (human)
one-carbon metabolic process	Carbonic anhydrase 3	Homo sapiens (human)
bicarbonate transport	Carbonic anhydrase 4	Homo sapiens (human)
one-carbon metabolic process	Carbonic anhydrase 4	Homo sapiens (human)
one-carbon metabolic process	Carbonic anhydrase 14	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
arylesterase activity	Carbonic anhydrase 1	Homo sapiens (human)
carbonate dehydratase activity	Carbonic anhydrase 1	Homo sapiens (human)
protein binding	Carbonic anhydrase 1	Homo sapiens (human)
zinc ion binding	Carbonic anhydrase 1	Homo sapiens (human)
hydro-lyase activity	Carbonic anhydrase 1	Homo sapiens (human)
cyanamide hydratase activity	Carbonic anhydrase 1	Homo sapiens (human)
carbonate dehydratase activity	Carbonic anhydrase 3	Homo sapiens (human)
protein binding	Carbonic anhydrase 3	Homo sapiens (human)
zinc ion binding	Carbonic anhydrase 3	Homo sapiens (human)
nickel cation binding	Carbonic anhydrase 3	Homo sapiens (human)
protein binding	Carbonic anhydrase 4	Homo sapiens (human)
zinc ion binding	Carbonic anhydrase 4	Homo sapiens (human)
carbonate dehydratase activity	Carbonic anhydrase 4	Homo sapiens (human)
zinc ion binding	Carbonic anhydrase 14	Homo sapiens (human)
carbonate dehydratase activity	Carbonic anhydrase 14	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
cytosol	Carbonic anhydrase 1	Homo sapiens (human)
extracellular exosome	Carbonic anhydrase 1	Homo sapiens (human)
cytosol	Carbonic anhydrase 3	Homo sapiens (human)
cytosol	Carbonic anhydrase 3	Homo sapiens (human)
cytoplasm	Carbonic anhydrase 3	Homo sapiens (human)
basolateral plasma membrane	Carbonic anhydrase 4	Homo sapiens (human)
rough endoplasmic reticulum	Carbonic anhydrase 4	Homo sapiens (human)
endoplasmic reticulum-Golgi intermediate compartment	Carbonic anhydrase 4	Homo sapiens (human)
Golgi apparatus	Carbonic anhydrase 4	Homo sapiens (human)
trans-Golgi network	Carbonic anhydrase 4	Homo sapiens (human)
plasma membrane	Carbonic anhydrase 4	Homo sapiens (human)
external side of plasma membrane	Carbonic anhydrase 4	Homo sapiens (human)
cell surface	Carbonic anhydrase 4	Homo sapiens (human)
membrane	Carbonic anhydrase 4	Homo sapiens (human)
apical plasma membrane	Carbonic anhydrase 4	Homo sapiens (human)
transport vesicle membrane	Carbonic anhydrase 4	Homo sapiens (human)
secretory granule membrane	Carbonic anhydrase 4	Homo sapiens (human)
brush border membrane	Carbonic anhydrase 4	Homo sapiens (human)
perinuclear region of cytoplasm	Carbonic anhydrase 4	Homo sapiens (human)
extracellular exosome	Carbonic anhydrase 4	Homo sapiens (human)
plasma membrane	Carbonic anhydrase 4	Homo sapiens (human)
plasma membrane	Carbonic anhydrase 14	Homo sapiens (human)
membrane	Carbonic anhydrase 14	Homo sapiens (human)
basolateral plasma membrane	Carbonic anhydrase 14	Homo sapiens (human)
apical plasma membrane	Carbonic anhydrase 14	Homo sapiens (human)
plasma membrane	Carbonic anhydrase 14	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Assay ID	Title	Year	Journal	Article
AID753972	Inhibition of human carbonic anhydrase 7 at >100 uM preincubated for 15 mins by stopped flow CO2 hydrase assay	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Natural product hybrid and its superacid synthesized analogues: dodoneine and its derivatives show selective inhibition of carbonic anhydrase isoforms I, III, XIII and XIV.
AID753982	Inhibition of human carbonic anhydrase 3 preincubated for 15 mins by stopped flow CO2 hydrase assay	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Natural product hybrid and its superacid synthesized analogues: dodoneine and its derivatives show selective inhibition of carbonic anhydrase isoforms I, III, XIII and XIV.
AID753974	Inhibition of human carbonic anhydrase 6 at >100 uM preincubated for 15 mins by stopped flow CO2 hydrase assay	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Natural product hybrid and its superacid synthesized analogues: dodoneine and its derivatives show selective inhibition of carbonic anhydrase isoforms I, III, XIII and XIV.
AID753971	Inhibition of human carbonic anhydrase 9 at >100 uM preincubated for 15 mins by stopped flow CO2 hydrase assay	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Natural product hybrid and its superacid synthesized analogues: dodoneine and its derivatives show selective inhibition of carbonic anhydrase isoforms I, III, XIII and XIV.
AID753983	Inhibition of human carbonic anhydrase 2 at >100 uM preincubated for 15 mins by stopped flow CO2 hydrase assay	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Natural product hybrid and its superacid synthesized analogues: dodoneine and its derivatives show selective inhibition of carbonic anhydrase isoforms I, III, XIII and XIV.
AID753986	Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydrase assay	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Natural product hybrid and its superacid synthesized analogues: dodoneine and its derivatives show selective inhibition of carbonic anhydrase isoforms I, III, XIII and XIV.
AID312042	Vasorelaxant effect on norepinephrine induced-contraction in Wistar rat aortic rings	2007	Journal of natural products, Dec, Volume: 70, Issue:12	Structure elucidation of a dihydropyranone from Tapinanthus dodoneifolius.
AID753965	Inhibition of human carbonic anhydrase 14 preincubated for 15 mins by stopped flow CO2 hydrase assay	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Natural product hybrid and its superacid synthesized analogues: dodoneine and its derivatives show selective inhibition of carbonic anhydrase isoforms I, III, XIII and XIV.
AID753977	Inhibition of human carbonic anhydrase 5a at >100 uM preincubated for 15 mins by stopped flow CO2 hydrase assay	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Natural product hybrid and its superacid synthesized analogues: dodoneine and its derivatives show selective inhibition of carbonic anhydrase isoforms I, III, XIII and XIV.
AID753968	Inhibition of human carbonic anhydrase 12 at >100 uM preincubated for 15 mins by stopped flow CO2 hydrase assay	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Natural product hybrid and its superacid synthesized analogues: dodoneine and its derivatives show selective inhibition of carbonic anhydrase isoforms I, III, XIII and XIV.
AID753967	Inhibition of mouse carbonic anhydrase 13 preincubated for 15 mins by stopped flow CO2 hydrase assay	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Natural product hybrid and its superacid synthesized analogues: dodoneine and its derivatives show selective inhibition of carbonic anhydrase isoforms I, III, XIII and XIV.
AID753975	Inhibition of human carbonic anhydrase 5b at >100 uM preincubated for 15 mins by stopped flow CO2 hydrase assay	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Natural product hybrid and its superacid synthesized analogues: dodoneine and its derivatives show selective inhibition of carbonic anhydrase isoforms I, III, XIII and XIV.
AID753980	Inhibition of human carbonic anhydrase 4 preincubated for 15 mins by stopped flow CO2 hydrase assay	2013	Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13	Natural product hybrid and its superacid synthesized analogues: dodoneine and its derivatives show selective inhibition of carbonic anhydrase isoforms I, III, XIII and XIV.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (20.00)	29.6817
2010's	4 (80.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (20.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	4 (80.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Condition	Indicated	Relationship Strength	Studies	Trials
Blood Pressure, High [description not available]	0	3.06	1	0
Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.	0	3.06	1	0

dodoneine

Description

Related Flora

Cross-References

Synonyms (4)

Protein Targets (5)

Inhibition Measurements

Biological Processes (3)

Molecular Functions (7)

Ceullar Components (17)

Bioassays (13)

Research

Studies (5)

Study Types

Related Conditions (2)