Page last updated: 2024-11-08

4-azidosulfanilamide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Cross-References

ID SourceID
PubMed CID3558590
CHEMBL ID222837
SCHEMBL ID15155897
MeSH IDM0082016

Synonyms (16)

Synonym
36326-86-0
nsc80928
nsc-80928
4-azidobenzenesulfonamide
chembl222837 ,
azide 1
bdbm15222
4-azidobenzene-1-sulfonamide
AKOS019150016
4-azido-benzenesulfonamide
4-azidophenylsulfonamide
SCHEMBL15155897
diazosulfanilamide
4-azido benzenesulfonamide
EN300-191209
Z1413773283
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (5)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Carbonic anhydrase 1Homo sapiens (human)Ki2.80740.00001.372610.0000AID1797360; AID281082; AID300867; AID353228; AID366657
Carbonic anhydrase 2Homo sapiens (human)Ki0.60570.00000.72369.9200AID1797360; AID281083; AID300868; AID353229; AID366658
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)Ki0.05600.00001.27259.9000AID366659
Carbonic anhydrase 9Homo sapiens (human)Ki0.72780.00010.78749.9000AID1797360; AID281084; AID300869; AID353230
Carbonic anhydrase 5B, mitochondrialHomo sapiens (human)Ki0.05580.00001.34129.9700AID366660
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (16)

Processvia Protein(s)Taxonomy
one-carbon metabolic processCarbonic anhydrase 1Homo sapiens (human)
morphogenesis of an epitheliumCarbonic anhydrase 2Homo sapiens (human)
positive regulation of synaptic transmission, GABAergicCarbonic anhydrase 2Homo sapiens (human)
positive regulation of cellular pH reductionCarbonic anhydrase 2Homo sapiens (human)
angiotensin-activated signaling pathwayCarbonic anhydrase 2Homo sapiens (human)
regulation of monoatomic anion transportCarbonic anhydrase 2Homo sapiens (human)
secretionCarbonic anhydrase 2Homo sapiens (human)
regulation of intracellular pHCarbonic anhydrase 2Homo sapiens (human)
neuron cellular homeostasisCarbonic anhydrase 2Homo sapiens (human)
positive regulation of dipeptide transmembrane transportCarbonic anhydrase 2Homo sapiens (human)
regulation of chloride transportCarbonic anhydrase 2Homo sapiens (human)
carbon dioxide transportCarbonic anhydrase 2Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 2Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
response to hypoxiaCarbonic anhydrase 9Homo sapiens (human)
morphogenesis of an epitheliumCarbonic anhydrase 9Homo sapiens (human)
response to xenobiotic stimulusCarbonic anhydrase 9Homo sapiens (human)
response to testosteroneCarbonic anhydrase 9Homo sapiens (human)
secretionCarbonic anhydrase 9Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 9Homo sapiens (human)
response to bacteriumCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (7)

Processvia Protein(s)Taxonomy
arylesterase activityCarbonic anhydrase 1Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 1Homo sapiens (human)
protein bindingCarbonic anhydrase 1Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 1Homo sapiens (human)
hydro-lyase activityCarbonic anhydrase 1Homo sapiens (human)
cyanamide hydratase activityCarbonic anhydrase 1Homo sapiens (human)
arylesterase activityCarbonic anhydrase 2Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 2Homo sapiens (human)
protein bindingCarbonic anhydrase 2Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 2Homo sapiens (human)
cyanamide hydratase activityCarbonic anhydrase 2Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
zinc ion bindingCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 9Homo sapiens (human)
protein bindingCarbonic anhydrase 9Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 9Homo sapiens (human)
molecular function activator activityCarbonic anhydrase 9Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
zinc ion bindingCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (12)

Processvia Protein(s)Taxonomy
cytosolCarbonic anhydrase 1Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 1Homo sapiens (human)
cytoplasmCarbonic anhydrase 2Homo sapiens (human)
cytosolCarbonic anhydrase 2Homo sapiens (human)
plasma membraneCarbonic anhydrase 2Homo sapiens (human)
myelin sheathCarbonic anhydrase 2Homo sapiens (human)
apical part of cellCarbonic anhydrase 2Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 2Homo sapiens (human)
cytoplasmCarbonic anhydrase 2Homo sapiens (human)
plasma membraneCarbonic anhydrase 2Homo sapiens (human)
apical part of cellCarbonic anhydrase 2Homo sapiens (human)
mitochondrial matrixCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
mitochondrionCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
cytoplasmCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
mitochondrionCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
nucleolusCarbonic anhydrase 9Homo sapiens (human)
plasma membraneCarbonic anhydrase 9Homo sapiens (human)
membraneCarbonic anhydrase 9Homo sapiens (human)
basolateral plasma membraneCarbonic anhydrase 9Homo sapiens (human)
microvillus membraneCarbonic anhydrase 9Homo sapiens (human)
plasma membraneCarbonic anhydrase 9Homo sapiens (human)
mitochondrionCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
mitochondrial matrixCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
mitochondrionCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
cytoplasmCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (24)

Assay IDTitleYearJournalArticle
AID366657Inhibition of human cloned CA1 by CO2 hydration assay2008Bioorganic & medicinal chemistry letters, Aug-15, Volume: 18, Issue:16
Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives.
AID306207Antimicrobial activity against Staphylococcus aureus2007Bioorganic & medicinal chemistry letters, Mar-01, Volume: 17, Issue:5
Anti-mycobacterial activity of a bis-sulfonamide.
AID353230Inhibition of human recombinant CA9 by stopped flow CO2 hydration assay2009Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8
Inhibition of carbonic anhydrase isozymes with benzene sulfonamides incorporating thio, sulfinyl and sulfonyl glycoside moieties.
AID306206Antimicrobial activity against Escherichia coli2007Bioorganic & medicinal chemistry letters, Mar-01, Volume: 17, Issue:5
Anti-mycobacterial activity of a bis-sulfonamide.
AID306208Antimicrobial activity against Vibrio harveyi2007Bioorganic & medicinal chemistry letters, Mar-01, Volume: 17, Issue:5
Anti-mycobacterial activity of a bis-sulfonamide.
AID281086Selectivity ratio of human CA9 over human CA22007Journal of medicinal chemistry, Apr-05, Volume: 50, Issue:7
Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides.
AID353228Inhibition of human recombinant CA1 by stopped flow CO2 hydration assay2009Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8
Inhibition of carbonic anhydrase isozymes with benzene sulfonamides incorporating thio, sulfinyl and sulfonyl glycoside moieties.
AID353231Inhibition of human recombinant CA12 by stopped flow CO2 hydration assay2009Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8
Inhibition of carbonic anhydrase isozymes with benzene sulfonamides incorporating thio, sulfinyl and sulfonyl glycoside moieties.
AID366659Inhibition of human recombinant CA5A by CO2 hydration assay2008Bioorganic & medicinal chemistry letters, Aug-15, Volume: 18, Issue:16
Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives.
AID281084Inhibition of catalytic domain of human recombinant isozyme CA9 by CO2 hydration method2007Journal of medicinal chemistry, Apr-05, Volume: 50, Issue:7
Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides.
AID281083Inhibition of human recombinant isozyme CA2 by CO2 hydration method2007Journal of medicinal chemistry, Apr-05, Volume: 50, Issue:7
Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides.
AID300870Selectivity ratio of Ki for human cloned CA1 to Ki for human cloned catalytic domain CA92007Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18
Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety.
AID281082Inhibition of human recombinant isozyme CA1 by CO2 hydration method2007Journal of medicinal chemistry, Apr-05, Volume: 50, Issue:7
Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides.
AID366660Inhibition of human recombinant CA5B by CO2 hydration assay2008Bioorganic & medicinal chemistry letters, Aug-15, Volume: 18, Issue:16
Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives.
AID300868Inhibition of human cloned CA2 by CO2 hydration method2007Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18
Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety.
AID300867Inhibition of human cloned CA1 by CO2 hydration method2007Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18
Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety.
AID353229Inhibition of human recombinant CA2 by stopped flow CO2 hydration assay2009Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8
Inhibition of carbonic anhydrase isozymes with benzene sulfonamides incorporating thio, sulfinyl and sulfonyl glycoside moieties.
AID306204Antimicrobial activity against Mycobacterium smegmatis2007Bioorganic & medicinal chemistry letters, Mar-01, Volume: 17, Issue:5
Anti-mycobacterial activity of a bis-sulfonamide.
AID300869Inhibition of human cloned catalytic domain CA9 by CO2 hydration method2007Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18
Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety.
AID300871Selectivity ratio of Ki for human cloned CA1 to Ki for human cloned catalytic domain CA92007Bioorganic & medicinal chemistry letters, Sep-15, Volume: 17, Issue:18
Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety.
AID306205Antimicrobial activity against Candida albicans2007Bioorganic & medicinal chemistry letters, Mar-01, Volume: 17, Issue:5
Anti-mycobacterial activity of a bis-sulfonamide.
AID366658Inhibition of human cloned CA2 by CO2 hydration assay2008Bioorganic & medicinal chemistry letters, Aug-15, Volume: 18, Issue:16
Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives.
AID281085Selectivity ratio of human CA9 over human CA12007Journal of medicinal chemistry, Apr-05, Volume: 50, Issue:7
Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides.
AID1797360CA Inhibition Assay from Article 10.1021/jm061320h: \\Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides.\\2007Journal of medicinal chemistry, Apr-05, Volume: 50, Issue:7
Carbonic anhydrase inhibitors: inhibition of isozymes I, II, and IX with triazole-linked O-glycosides of benzene sulfonamides.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]