Compounds > lasiodiplodin
Page last updated: 2024-11-12

lasiodiplodin

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Description

lasiodiplodin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID14562696
CHEMBL ID393258
SCHEMBL ID23484270
MeSH IDM0375582

Synonyms (13)

Synonym
CHEMBL393258
lasiodiplodin
32885-81-7
(9s)-15-hydroxy-13-methoxy-9-methyl-10-oxabicyclo[10.4.0]hexadeca-1(12),13,15-trien-11-one
(s)-lasiodiplodin
AKOS032948907
Q59287150
FS-9431
SCHEMBL23484270
(4s)-14-hydroxy-16-methoxy-4-methyl-3-oxabicyclo[10.4.0]hexadeca-1(12),13,15-trien-2-one
(3s)-12-hydroxy-14-methoxy-3-methyl-3,4,5,6,7,8,9,10-octahydro-1h-2-benzoxacyclododecin-1-one
HY-N3401
CS-0024135
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (42)

Assay IDTitleYearJournalArticle
AID1327709Cytotoxicity against human HCT116 cells at 10 uM measured after 72 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
Spirobisnaphthalenes and lactones from the seeds of Strychnos angustiflora with potential anti-inflammatory activity.
AID1090668Inhibition of thylakoid electron transport chain in intact chloroplasts of Spinacia oleracea (spinach) leaves assessed as inhibition of uncoupled PS2 electron transport from water to DCPIP at 200 uM relative to control2007Journal of agricultural and food chemistry, May-16, Volume: 55, Issue:10
Inhibition of photophosphorylation and electron transport chain in thylakoids by lasiodiplodin, a natural product from Botryosphaeria rhodina.
AID269646Antifungal activity against Fusarium oxysporum f.sp.cubense2006Bioorganic & medicinal chemistry letters, Aug-15, Volume: 16, Issue:16
Lactones from a brown alga endophytic fungus (No. ZZF36) from the South China Sea and their antimicrobial activities.
AID1090674In vitro inhibition of photophosphorylation in intact chloroplasts of Spinacia oleracea (spinach) leaves assessed as basal electron transport from water to methylviologen2007Journal of agricultural and food chemistry, May-16, Volume: 55, Issue:10
Inhibition of photophosphorylation and electron transport chain in thylakoids by lasiodiplodin, a natural product from Botryosphaeria rhodina.
AID1090651Inhibition of Mg2+ ATPase activity of coupling factor 1 in chloroplasts of Spinacia oleracea (spinach) leaves at 50 uM2007Journal of agricultural and food chemistry, May-16, Volume: 55, Issue:10
Inhibition of photophosphorylation and electron transport chain in thylakoids by lasiodiplodin, a natural product from Botryosphaeria rhodina.
AID1090658Inhibition of H+ ATPase activity of coupling factor 1 in chloroplasts of Spinacia oleracea (spinach) leaves at 150 uM2007Journal of agricultural and food chemistry, May-16, Volume: 55, Issue:10
Inhibition of photophosphorylation and electron transport chain in thylakoids by lasiodiplodin, a natural product from Botryosphaeria rhodina.
AID1090652Inhibition of Mg2+ ATPase activity of coupling factor 1 in chloroplasts of Spinacia oleracea leaves at 25 uM2007Journal of agricultural and food chemistry, May-16, Volume: 55, Issue:10
Inhibition of photophosphorylation and electron transport chain in thylakoids by lasiodiplodin, a natural product from Botryosphaeria rhodina.
AID1090648Induction of Chlorophyll a fluorescence induction curve in freshly lysed chloroplasts of Spinacia oleracea (spinach) at 10 uM2007Journal of agricultural and food chemistry, May-16, Volume: 55, Issue:10
Inhibition of photophosphorylation and electron transport chain in thylakoids by lasiodiplodin, a natural product from Botryosphaeria rhodina.
AID1090663Inhibition of thylakoid electron transport chain in intact chloroplasts of Spinacia oleracea (spinach) leaves assessed as inhibition of uncoupled PS2 electron transport from water to SiM at 300 uM relative to control2007Journal of agricultural and food chemistry, May-16, Volume: 55, Issue:10
Inhibition of photophosphorylation and electron transport chain in thylakoids by lasiodiplodin, a natural product from Botryosphaeria rhodina.
AID269644Antibacterial activity against Salmonella enteritidis ATCC 130762006Bioorganic & medicinal chemistry letters, Aug-15, Volume: 16, Issue:16
Lactones from a brown alga endophytic fungus (No. ZZF36) from the South China Sea and their antimicrobial activities.
AID1327712Cytotoxicity against human NCI-H1650 cells at 10 uM measured after 72 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
Spirobisnaphthalenes and lactones from the seeds of Strychnos angustiflora with potential anti-inflammatory activity.
AID305717Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay2007Bioorganic & medicinal chemistry, Feb-01, Volume: 15, Issue:3
Rotenoids and flavonoids with anti-invasion of HT1080, anti-proliferation of U937, and differentiation-inducing activity in HL-60 from Erycibe expansa.
AID1090670Inhibition of ATP sythesis in freshly lysed Spinacia oleracea (spinach) chloroplasts at 150 uM2007Journal of agricultural and food chemistry, May-16, Volume: 55, Issue:10
Inhibition of photophosphorylation and electron transport chain in thylakoids by lasiodiplodin, a natural product from Botryosphaeria rhodina.
AID1090662Inhibition of thylakoid electron transport chain in intact chloroplasts of Spinacia oleracea (spinach) leaves assessed as inhibition of uncoupled PS2 electron transport from water to SiM at 400 uM relative to control2007Journal of agricultural and food chemistry, May-16, Volume: 55, Issue:10
Inhibition of photophosphorylation and electron transport chain in thylakoids by lasiodiplodin, a natural product from Botryosphaeria rhodina.
AID1090655Inhibition of Ca2+ ATPase activity of coupling factor 1 in chloroplasts of Spinacia oleracea (spinach) leaves at 25 uM2007Journal of agricultural and food chemistry, May-16, Volume: 55, Issue:10
Inhibition of photophosphorylation and electron transport chain in thylakoids by lasiodiplodin, a natural product from Botryosphaeria rhodina.
AID1090660Inhibition of thylakoid electron transport chain in intact chloroplasts of Spinacia oleracea (spinach) leaves assessed as inhibition of uncoupled PS2 electron transport from DCP to DCPIP at 200 uM relative to control2007Journal of agricultural and food chemistry, May-16, Volume: 55, Issue:10
Inhibition of photophosphorylation and electron transport chain in thylakoids by lasiodiplodin, a natural product from Botryosphaeria rhodina.
AID1327710Cytotoxicity against human HepG2 cells at 10 uM measured after 72 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
Spirobisnaphthalenes and lactones from the seeds of Strychnos angustiflora with potential anti-inflammatory activity.
AID1090673Inhibition of ATP sythesis in freshly lysed Spinacia oleracea (spinach) chloroplasts2007Journal of agricultural and food chemistry, May-16, Volume: 55, Issue:10
Inhibition of photophosphorylation and electron transport chain in thylakoids by lasiodiplodin, a natural product from Botryosphaeria rhodina.
AID1090654Inhibition of Ca2+ ATPase activity of coupling factor 1 in chloroplasts of Spinacia oleracea (spinach) leaves at 150 uM2007Journal of agricultural and food chemistry, May-16, Volume: 55, Issue:10
Inhibition of photophosphorylation and electron transport chain in thylakoids by lasiodiplodin, a natural product from Botryosphaeria rhodina.
AID269641Antibacterial activity against Staphylococcus aureus ATCC 271542006Bioorganic & medicinal chemistry letters, Aug-15, Volume: 16, Issue:16
Lactones from a brown alga endophytic fungus (No. ZZF36) from the South China Sea and their antimicrobial activities.
AID1090672In vitro inhibition of photophosphorylation in intact chloroplasts of Spinacia oleracea (spinach) leaves assessed as phosphorylating nonyclic electron transport from water to methylviologen2007Journal of agricultural and food chemistry, May-16, Volume: 55, Issue:10
Inhibition of photophosphorylation and electron transport chain in thylakoids by lasiodiplodin, a natural product from Botryosphaeria rhodina.
AID1090661Inhibition of thylakoid electron transport chain in intact chloroplasts of Spinacia oleracea (spinach) leaves assessed as inhibition of uncoupled PS2 electron transport from DCP to DCPIP at 100 uM relative to control2007Journal of agricultural and food chemistry, May-16, Volume: 55, Issue:10
Inhibition of photophosphorylation and electron transport chain in thylakoids by lasiodiplodin, a natural product from Botryosphaeria rhodina.
AID1090657Inhibition of H+ ATPase activity of coupling factor 1 in chloroplasts of Spinacia oleracea (spinach) leaves at 50 uM2007Journal of agricultural and food chemistry, May-16, Volume: 55, Issue:10
Inhibition of photophosphorylation and electron transport chain in thylakoids by lasiodiplodin, a natural product from Botryosphaeria rhodina.
AID1090666Inhibition of thylakoid electron transport chain in intact chloroplasts of Spinacia oleracea (spinach) leaves assessed as inhibition of uncoupled PS2 electron transport from water to DCPIP at 400 uM relative to control2007Journal of agricultural and food chemistry, May-16, Volume: 55, Issue:10
Inhibition of photophosphorylation and electron transport chain in thylakoids by lasiodiplodin, a natural product from Botryosphaeria rhodina.
AID1090649Inhibition of Mg2+ ATPase activity of coupling factor 1 in chloroplasts of Spinacia oleracea (spinach) leaves at 150 uM2007Journal of agricultural and food chemistry, May-16, Volume: 55, Issue:10
Inhibition of photophosphorylation and electron transport chain in thylakoids by lasiodiplodin, a natural product from Botryosphaeria rhodina.
AID1327713Cytotoxicity against human A2780 cells at 10 uM measured after 72 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
Spirobisnaphthalenes and lactones from the seeds of Strychnos angustiflora with potential anti-inflammatory activity.
AID269642Antibacterial activity against Bacillus subtilis ATCC 66332006Bioorganic & medicinal chemistry letters, Aug-15, Volume: 16, Issue:16
Lactones from a brown alga endophytic fungus (No. ZZF36) from the South China Sea and their antimicrobial activities.
AID1327708Inhibition of LPS-induced nitric oxide production in mouse BV2 cells pretreated for 1 hr before LPS stimulation measured after 24 hrs by Griess assay2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
Spirobisnaphthalenes and lactones from the seeds of Strychnos angustiflora with potential anti-inflammatory activity.
AID1090650Induction of Chlorophyll a fluorescence induction curve in freshly lysed chloroplasts of Spinacia oleracea (spinach) at 300 uM2007Journal of agricultural and food chemistry, May-16, Volume: 55, Issue:10
Inhibition of photophosphorylation and electron transport chain in thylakoids by lasiodiplodin, a natural product from Botryosphaeria rhodina.
AID305716Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay2007Bioorganic & medicinal chemistry, Feb-01, Volume: 15, Issue:3
Rotenoids and flavonoids with anti-invasion of HT1080, anti-proliferation of U937, and differentiation-inducing activity in HL-60 from Erycibe expansa.
AID1090659Inhibition of thylakoid electron transport chain in intact chloroplasts of Spinacia oleracea (spinach) leaves assessed as inhibition of uncoupled PS2 electron transport from DCP to DCPIP at 300 uM relative to control2007Journal of agricultural and food chemistry, May-16, Volume: 55, Issue:10
Inhibition of photophosphorylation and electron transport chain in thylakoids by lasiodiplodin, a natural product from Botryosphaeria rhodina.
AID1090667Inhibition of thylakoid electron transport chain in intact chloroplasts of Spinacia oleracea (spinach) leaves assessed as inhibition of uncoupled PS2 electron transport from water to DCPIP at 300 uM relative to control2007Journal of agricultural and food chemistry, May-16, Volume: 55, Issue:10
Inhibition of photophosphorylation and electron transport chain in thylakoids by lasiodiplodin, a natural product from Botryosphaeria rhodina.
AID269643Antibacterial activity against Escherichia coli ATCC 259222006Bioorganic & medicinal chemistry letters, Aug-15, Volume: 16, Issue:16
Lactones from a brown alga endophytic fungus (No. ZZF36) from the South China Sea and their antimicrobial activities.
AID1090671In vitro inhibition of photophosphorylation in intact chloroplasts of Spinacia oleracea (spinach) leaves assessed as inhibition of uncoupled electron transport from water to methylviologen at 300 uM2007Journal of agricultural and food chemistry, May-16, Volume: 55, Issue:10
Inhibition of photophosphorylation and electron transport chain in thylakoids by lasiodiplodin, a natural product from Botryosphaeria rhodina.
AID1090665Inhibition of thylakoid electron transport chain in intact chloroplasts of Spinacia oleracea (spinach) leaves assessed as inhibition of uncoupled PS2 electron transport from water to SiM at 100 uM relative to control2007Journal of agricultural and food chemistry, May-16, Volume: 55, Issue:10
Inhibition of photophosphorylation and electron transport chain in thylakoids by lasiodiplodin, a natural product from Botryosphaeria rhodina.
AID269645Antifungal activity against Candida albicans ATCC 102312006Bioorganic & medicinal chemistry letters, Aug-15, Volume: 16, Issue:16
Lactones from a brown alga endophytic fungus (No. ZZF36) from the South China Sea and their antimicrobial activities.
AID1090664Inhibition of thylakoid electron transport chain in intact chloroplasts of Spinacia oleracea (spinach) leaves assessed as inhibition of uncoupled PS2 electron transport from water to SiM at 200 uM relative to control2007Journal of agricultural and food chemistry, May-16, Volume: 55, Issue:10
Inhibition of photophosphorylation and electron transport chain in thylakoids by lasiodiplodin, a natural product from Botryosphaeria rhodina.
AID1090669Inhibition of thylakoid electron transport chain in intact chloroplasts of Spinacia oleracea (spinach) leaves assessed as inhibition of uncoupled PS2 electron transport from water to DCPIP at 100 uM relative to control2007Journal of agricultural and food chemistry, May-16, Volume: 55, Issue:10
Inhibition of photophosphorylation and electron transport chain in thylakoids by lasiodiplodin, a natural product from Botryosphaeria rhodina.
AID1090656Inhibition of H+ ATPase activity of coupling factor 1 in chloroplasts of Spinacia oleracea (spinach) leaves at 200 uM2007Journal of agricultural and food chemistry, May-16, Volume: 55, Issue:10
Inhibition of photophosphorylation and electron transport chain in thylakoids by lasiodiplodin, a natural product from Botryosphaeria rhodina.
AID1327711Cytotoxicity against human BGC823 cells at 10 uM measured after 72 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
Spirobisnaphthalenes and lactones from the seeds of Strychnos angustiflora with potential anti-inflammatory activity.
AID305715Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay2007Bioorganic & medicinal chemistry, Feb-01, Volume: 15, Issue:3
Rotenoids and flavonoids with anti-invasion of HT1080, anti-proliferation of U937, and differentiation-inducing activity in HL-60 from Erycibe expansa.
AID1090653Inhibition of Ca2+ ATPase activity of coupling factor 1 in chloroplasts of Spinacia oleracea (spinach) leaves at 50 uM2007Journal of agricultural and food chemistry, May-16, Volume: 55, Issue:10
Inhibition of photophosphorylation and electron transport chain in thylakoids by lasiodiplodin, a natural product from Botryosphaeria rhodina.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (37.50)29.6817
2010's9 (56.25)24.3611
2020's1 (6.25)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.34

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index21.34 (24.57)
Research Supply Index2.89 (2.92)
Research Growth Index4.93 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (21.34)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
methane
Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed). methane : A one-carbon compound in which the carbon is attached by single bonds to four hydrogen atoms. It is a colourless, odourless, non-toxic but flammable gas (b.p. -161degreeC).		210alkane;
gas molecular entity;
mononuclear parent hydride;
one-carbon compound		bacterial metabolite;
fossil fuel;
greenhouse gas
penicillamine
Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.. penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.		2.1510non-proteinogenic alpha-amino acid;
penicillamine		antirheumatic drug;
chelator;
copper chelator;
drug allergen
ampicillin
Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.		2.0310beta-lactam antibiotic;
penicillin allergen;
penicillin		antibacterial drug
rotenone
Derris: A plant genus of the family FABACEAE. The root is a source of rotenoids (ROTENONE) and flavonoids. Some species of Pongamia have been reclassified to this genus and some to MILLETTIA. Some species of Deguelia have been reclassified to this genus.. rotenoid : Members of the class of tetrahydrochromenochromene that consists of a cis-fused tetrahydrochromeno[3,4-b]chromene skeleton and its substituted derivatives. The term was originally restricted to natural products, but is now also used to describe semi-synthetic and fully synthetic compounds.		2.0310organic heteropentacyclic compound;
rotenones		antineoplastic agent;
metabolite;
mitochondrial NADH:ubiquinone reductase inhibitor;
phytogenic insecticide;
piscicide;
toxin
alpha-resorcylic acid
alpha-resorcylic acid: RN given refers to parent cpd. 3,5-dihydroxybenzoic acid : A dihydroxybenzoic acid in which the hydroxy groups are located at positions 3 and 5.		2.110dihydroxybenzoic acid;
resorcinols		metabolite
4-hydroxyphenylethanol
4-hydroxyphenylethanol: in chest gland secretion of galagos. 2-(4-hydroxyphenyl)ethanol : A phenol substituted at position 4 by a 2-hydroxyethyl group.		2.0310phenolsanti-arrhythmia drug;
antioxidant;
cardiovascular drug;
fungal metabolite;
geroprotector;
plant metabolite;
protective agent
ruthenium
Ruthenium: A hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.		710iron group element atom;
platinum group metal atom
camptothecin
NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source		2.0310delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite
deuterium
Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.		2.0510dihydrogen
fluorine
Fluorine: A nonmetallic, diatomic gas that is a trace element and member of the halogen family. It is used in dentistry as fluoride (FLUORIDES) to prevent dental caries.		210diatomic fluorine;
gas molecular entity		NMR chemical shift reference compound
phenyl acetate
phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.		2.0510benzenes;
phenyl acetates
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.0310taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
rotenolone
rotenolone: decomposition product of rotenone; RN given refers to (2 alpha,6a beta,12a beta)-isomer		2.0310organic molecular entitymetabolite
inermin
inermin: phytoalexin produced in plants after injection with fungi; RN given refers to (cis-(+-))-isomer; RN for cpd without isomeric designation; structure. (-)-maackiain : The (-)-enantiomer of maackiain.		2.0310maackiain
homopterocarpin
homopterocarpin: an insect antifeedant isolated from Pterocarpus marcocarpus; structure in first source		2.0310pterocarpans
deguelin
deguelin: a natural product from Mundulea sericea; RN refers to (7aS-cis)-isomer; structure given in first source. deguelin : A rotenone that is 13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one substituted by methoxy groups at positions 9 and 10, and by two methyl groups at position 3 (the 7aS,13aS-stereoisomer). It exists in abundant quantities in the bark, roots, and leaves of the Leguminosae family of plants and reported to exert anti-tumour effects in various cancers.		2.0310aromatic ether;
diether;
organic heteropentacyclic compound;
rotenones		angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
antiviral agent;
apoptosis inducer;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
mitochondrial NADH:ubiquinone reductase inhibitor;
plant metabolite
tephrosin
tephrosin: RN given for (7aR-cis)-isomer; has insecticidal activity; structure in first source. tephrosin : A member of the class of rotenones that is 13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one substituted with geminal methyl groups at position 3, hydroxy group at position 7a and methoxy groups at positions 9 and 10 (the 7aR,13aR stereoisomer). It is isolated from the leaves and twigs of Antheroporum pierrei and exhibits antineoplastic and pesticidal activities.		2.0310aromatic ether;
cyclic ketone;
organic heteropentacyclic compound;
rotenones		antineoplastic agent;
metabolite;
pesticide
carbene
carbene: electrically neutral species H2C: and its derivatives, in which the carbon is covalently bonded to two univalent groups of any kind or a divalent group and bears two nonbonding electrons; carbene is the name of the parent hydride :CH2 ; hence, the name dichlorocarbene for :CCl2. However, names for acyclic and cyclic hydrocarbons containing one or more divalent carbon atoms are derived from the name of the corresponding all-4-hydrocarbon using the suffix -ylidene; methylene carbene also available. carbene : The electrically neutral species H2C(2.) and its derivatives, in which the carbon is covalently bonded to two univalent groups of any kind or a divalent group and bears two nonbonding electrons, which may be spin-paired (singlet state) or spin-non-paired (triplet state).		710carbene;
methanediyl
eriodictyol
eriodictyol: structure. eriodictyol : A tetrahydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5, 7, 3' and 4' respectively.		2.03103'-hydroxyflavanones;
tetrahydroxyflavanone
ergosterol
[no description available]		2.03103beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
ergostanoid;
phytosterols		fungal metabolite;
Saccharomyces cerevisiae metabolite
cabreuvin
cabreuvin: structure in first source		2.0310methoxyisoflavone
sesquiterpenes
[no description available]		2.1510
curcumin
Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.. curcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.		2.1310aromatic ether;
beta-diketone;
diarylheptanoid;
enone;
polyphenol		anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
biological pigment;
contraceptive drug;
dye;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
EC 1.8.1.9 (thioredoxin reductase) inhibitor;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
flavouring agent;
food colouring;
geroprotector;
hepatoprotective agent;
immunomodulator;
iron chelator;
ligand;
lipoxygenase inhibitor;
metabolite;
neuroprotective agent;
nutraceutical;
radical scavenger
formononetin
[no description available]		2.03104'-methoxyisoflavones;
7-hydroxyisoflavones		phytoestrogen;
plant metabolite
luteolin
[no description available]		2.03103'-hydroxyflavonoid;
tetrahydroxyflavone		angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist
7,3'-dihydroxy-4'-methoxyisoflavone
7,3'-dihydroxy-4'-methoxyisoflavone: isolated from Astragali radix; structure in first source. calycosin : A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at the 3' position and a methoxy group at the 4' position.		2.03104'-methoxyisoflavones;
7-hydroxyisoflavones		antioxidant;
metabolite
calcitriol
dihydroxy-vitamin D3: as a major in vitro metabolite of 1alpha,25-dihydroxyvitamin D3, produced in primary cultures of neonatal human keratinocytes		2.0310D3 vitamins;
hydroxycalciol;
triol		antineoplastic agent;
antipsoriatic;
bone density conservation agent;
calcium channel agonist;
calcium channel modulator;
hormone;
human metabolite;
immunomodulator;
metabolite;
mouse metabolite;
nutraceutical
genistein
[no description available]		2.03107-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
zearalenone
Zearalenone: (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione. One of a group of compounds known under the general designation of resorcylic acid lactones. Cis, trans, dextro and levo forms have been isolated from the fungus Gibberella zeae (formerly Fusarium graminearum). They have estrogenic activity, cause toxicity in livestock as feed contaminant, and have been used as anabolic or estrogen substitutes.. zearalenone : A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.		9.02130macrolide;
resorcinols		fungal metabolite;
mycoestrogen
orobol
orobol: from Aspergillus niger or Streptomyces neyagawaensis; potent inhibitor of phosphatidylinositol kinase. orobol : A member of the class of 7-hydroxyisoflavones which consists of isoflavone substituted by hydroxy groups at positions 5, 7, 3' and 4'. It has been isolated from the mycelia of Cordyceps sinensis.		2.03107-hydroxyisoflavonesanti-inflammatory agent;
fungal metabolite;
plant metabolite;
radical scavenger
wighteone
wighteone : A member of the class of 7-hydroxyisoflavones that is isoflavone substituted by hydroxy groups at positions 5, 7 and 4' and a prenyl group at position 6. It has been isolated from Ficus mucuso.		2.03107-hydroxyisoflavonesantifungal agent;
plant metabolite
3'-o-methylorobol
3'-O-methylorobol: isolated from Eclipta prostrata; has stimulatory effect on mouse osteoblast differentiation; structure in first source. 3'-O-methylorobol : A hydroxyisoflavone that is orobol in which the hydroxy group at position 3' has been replaced by a methoxy group. It has been isolated from Crotalaria lachnophora.		2.0310hydroxyisoflavone;
methoxyisoflavone		plant metabolite
alpinumisoflavone
alpinumisoflavone: extract from twigs of poisonous British plant		2.0310isoflavanonesmetabolite
nystatin a1
Nystatin: Macrolide antifungal antibiotic complex produced by Streptomyces noursei, S. aureus, and other Streptomyces species. The biologically active components of the complex are nystatin A1, A2, and A3.. nystatin : A heterogeneous mixture of polyene compounds produced by cultures of Streptomyces noursei. It mainly consists of three biologically active components designated nystatin A1, nystatin A2, and nystatin A3. It is used to treat oral and dermal fungal infections.. nystatin A1 : A polyene macrolide antibiotic; part of the nystatin complex produced by several Streptomyces species. It is an antifungal antibiotic used for the treatment of topical fungal infections caused by a broad spectrum of fungal pathogens comprising yeast-like and filamentous species.		2.0310nystatins
de-o-methyllasiodiplodin
de-O-methyllasiodiplodin: structure in first source		2.1510
derrone
derrone: from Retama raetam flowers; structure in first source		2.0310isoflavonoid
inosine
[no description available]		2.0310inosines;
purines D-ribonucleoside		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Invasiveness, Neoplasm
[description not available]		02.0310
Fibrosarcoma
A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)		02.0310
Innate Inflammatory Response
[description not available]		02.4110
Pulmonary Consumption
[description not available]		02.4110
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.4110
Tuberculosis, Pulmonary
MYCOBACTERIUM infections of the lung.		02.4110