Page last updated: 2024-12-08

4'-hydroxyflurbiprofen

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

4'-hydroxyflurbiprofen: structure given in first source; RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID157678
CHEMBL ID1394
CHEBI ID174398
SCHEMBL ID6450842
MeSH IDM0180160

Synonyms (19)

Synonym
52807-12-2
CHEBI:174398
2-[3-luoro-4-(4-hydroxyphenyl)phenyl]propanoic acid
FPH ,
4'-hydroxyflurbiprofen
CHEMBL1394
2-(4'-hydroxy-2-fluoro-4-biphenylyl)propionic acid
FT-0669641
2-[3-fluoro-4-(4-hydroxyphenyl)phenyl]propanoic acid
4'-hydroxy flurbiprofen
(1,1'-biphenyl)-4-acetic acid, 2-fluoro-4'-hydroxy-alpha-methyl-
80685-20-7
SCHEMBL6450842
AKOS030255799
2-(2-fluoro-4'-hydroxy-[1,1'-biphenyl]-4-yl)propanoic acid
2-(2-fluoro-4'-hydroxy[1,1'-biphenyl]-4-yl)propanoic acid
DTXSID40967269
2-fluoro-4'-hydroxy-alpha-methyl-[1,1'-biphenyl]-4-acetic acid
2-{2-fluoro-4'-hydroxy-[1,1'-biphenyl]-4-yl}propanoic acid

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" Flurbiprofen half-life and Tmax were not different."( Pharmacokinetic comparison of flurbiprofen in end-stage renal disease subjects and subjects with normal renal function.
Cefali, EA; Cox, S; Poynor, WJ; Sica, D, 1991
)
0.28
" Plasma and urine samples were collected over 24 h, and flurbiprofen and 4'-hydroxyflurbiprofen pharmacokinetic data were compared across genotypes."( Differences in flurbiprofen pharmacokinetics between CYP2C9*1/*1, *1/*2, and *1/*3 genotypes.
Blaisdell, JA; Frye, RF; Goldstein, JA; Hinderliter, AL; Lee, CR; Pieper, JA, 2003
)
0.55

Bioavailability

ExcerptReferenceRelevance
" In rats, some of the compounds appeared to be well absorbed after oral administration and to penetrate into the central nervous system."( Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion.
Bigogno, C; Biscaioli, M; Bolzoni, PT; Caruso, P; Catinella, S; Cenacchi, V; Del Giudice, E; Dondio, G; Facchinetti, F; Fontanella, L; Imbimbo, BP; Marchetti, S; Misiano, P; Moretto, N; Parini, C; Peretto, I; Puccini, P; Radaelli, S; Raveglia, LF; Riccardi, B; Rizzi, A; Rondelli, I; Villetti, G; Zandi, M, 2005
)
0.33
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
biphenylsBenzenoid aromatic compounds containing two phenyl or substituted-phenyl groups which are joined together by a single bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID256360Percent inhibition against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL) at 100 uM2005Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18
Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion.
AID254925Concentration required to inhibit amyloid beta 42 peptide; nd is not determined2005Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18
Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (23.08)18.2507
2000's5 (38.46)29.6817
2010's5 (38.46)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.57

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.57 (24.57)
Research Supply Index2.89 (2.92)
Research Growth Index4.46 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.57)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials4 (30.77%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (69.23%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]