Page last updated: 2024-12-06

djenkolic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

djenkolic acid: amino acid isolated from djenkol bean; RN given refers to (L)-isomer; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

L-djenkolic acid : A dithioacetal consisting of two molecules of L-cysteine joined via their sulfanyl groups to methylene. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID68134
CHEMBL ID3138615
CHEBI ID6211
SCHEMBL ID151396
MeSH IDM0046062

Synonyms (38)

Synonym
3,3'-methylenedithiobis(2-aminopropanoic acid)
djenkolate
l-cysteine thioacetal of formaldehyde
nsc-76076
l-djenkolate
498-59-9
l-djenkolic acid
djenkolic acid
C08275
beta,beta'-methylenedithiodialanine
s,s'-methylenedi-l-cysteine
D0961
3,3'-(methylenedithio)dialanine
einecs 207-863-4
l-cysteine, s,s'-methylenebis-
unii-3qhc9r0yfz
nsc 76076
3qhc9r0yfz ,
alanine, 3,3'-(methylenedithio)di-, l-
alanine, 3,3'-(methylenedithio)di-
s,s'-methylenebis-l-cysteine
s,s'-methylenebiscysteine
CHEMBL3138615
chebi:6211 ,
S4954
djenkolic acid [mi]
SCHEMBL151396
s,s'-methylenebis(cysteine)
s,s'-methylene-bis-l-cysteine
(2r,2'r)-3,3'-(methylenedisulfanediyl)bis(2-aminopropanoic acid)
DTXSID80198075
AKOS030538008
(2r,2'r)-3,3'-methylenebis(sulfanediyl)bis(2-aminopropanoic acid)
Q4263761
(2r)-2-amino-3-[[(2r)-2-amino-2-carboxyethyl]sulfanylmethylsulfanyl]propanoic acid
T70966
CS-0103073
HY-125923
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
toxinPoisonous substance produced by a biological organism such as a microbe, animal or plant.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
dithioacetalA thioacetal having the structure R2C(SR')2. The term includes dithioketals (R =/= H, R' =/= H) as a subclass.
L-cysteine derivativeA proteinogenic amino acid derivative resulting from the formal reaction of L-cysteine at the amino group, carboxy group, or thiol group, or from the replacement of any hydrogen of L-cysteine by a heteroatom.
non-proteinogenic L-alpha-amino acidAny L-alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID977602Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM2013Molecular pharmacology, Jun, Volume: 83, Issue:6
Structure-based identification of OATP1B1/3 inhibitors.
AID977599Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM2013Molecular pharmacology, Jun, Volume: 83, Issue:6
Structure-based identification of OATP1B1/3 inhibitors.
AID1159550Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening2015Nature cell biology, Nov, Volume: 17, Issue:11
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (21)

TimeframeStudies, This Drug (%)All Drugs %
pre-19908 (38.10)18.7374
1990's2 (9.52)18.2507
2000's4 (19.05)29.6817
2010's6 (28.57)24.3611
2020's1 (4.76)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 40.25

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index40.25 (24.57)
Research Supply Index3.09 (2.92)
Research Growth Index4.71 (4.65)
Search Engine Demand Index54.47 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (40.25)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (4.76%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other20 (95.24%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]