Page last updated: 2024-12-07

tabtoxin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

tabtoxin: dipeptide containing tabtoxinine-beta-lactam with threonine; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

tabtoxin : A monobactam phytotoxic dipeptide produced by Pseudomonas syringae, that causes wildfire disease in tobacco. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID107817
CHEMBL ID3781539
CHEBI ID156429
MeSH IDM0044965

Synonyms (20)

Synonym
tabtoxin
n-{(2s)-2-amino-4-[(3s)-3-hydroxy-2-oxoazetidin-3-yl]butanoyl}-l-threonine
n-((2s)-2-amino-4-((3s)-3-hydroxy-2-oxo-3-azetidinyl)-1-oxobutyl)-l-threonine
40957-90-2
CHEBI:156429
(2s,3r)-2-({(2s)-2-amino-4-[(3s)-3-hydroxy-2-oxoazetidin-3-yl]butanoyl}amino)-3-hydroxybutanoic acid
wildfire toxin
(2s,3r)-2-[[(2s)-2-amino-4-[(3s)-3-hydroxy-2-oxoazetidin-3-yl]butanoyl]amino]-3-hydroxybutanoic acid
l-threonine, n-((2s)-2-amino-4-((3s)-3-hydroxy-2-oxo-3-azetidinyl)-1-oxobutyl)-
l-threonine, 4-(3-hydroxy-2-oxo-3-azetidinyl)-l-2-aminobutanoyl-, (s)-
unii-h3yx70r64n
h3yx70r64n ,
beta-tabtoxin
C20917
32190-57-1
wildfire toxin [mi]
CHEMBL3781539
Q7673587
DTXSID70961331
AKOS040754129

Research Excerpts

Overview

Tattoxin is a β-lactam ring-containing phytotoxin. It is produced by a plant pathogenic organism.

ExcerptReferenceRelevance
"Tabtoxin is a β-lactam ring-containing phytotoxin produced by a plant pathogenic "( Characterization of Enzymes Catalyzing the Initial Steps of the β-Lactam Tabtoxin Biosynthesis.
Abe, I; Lyu, J; Ushimaru, R, 2022
)
2.4
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
bacterial metaboliteAny prokaryotic metabolite produced during a metabolic reaction in bacteria.
toxinPoisonous substance produced by a biological organism such as a microbe, animal or plant.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (4)

ClassDescription
monobactamMonocyclic, bacterially produced or semisynthetic beta-lactam antibiotic. It lacks the double ring construction of the traditional beta-lactam antibiotics and can be easily synthesized.
dipeptideAny molecule that contains two amino-acid residues connected by peptide linkages.
L-threonine derivativeA proteinogenic amino acid derivative resulting from reaction of L-threonine at the amino group or the carboxy group, or from the replacement of any hydrogen of L-threonine by a heteroatom.
secondary alcoholA secondary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has two other carbon atoms attached to it.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (19)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (5.26)18.7374
1990's9 (47.37)18.2507
2000's3 (15.79)29.6817
2010's5 (26.32)24.3611
2020's1 (5.26)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 30.73

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index30.73 (24.57)
Research Supply Index3.04 (2.92)
Research Growth Index5.42 (4.65)
Search Engine Demand Index36.71 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (30.73)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (15.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (85.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]