Page last updated: 2024-09-28

Mahaim-Type Pre-Excitation

A form of ventricular pre-excitation characterized by a normal PR interval and a long QRS interval with an initial slow deflection (delta wave). In this syndrome, the atrial impulse travel to the ventricle via the MAHAIM FIBERS which connect ATRIOVENTRICULAR NODE directly to the right ventricle wall (NODOVENTRICULAR ACCESSORY PATHWAY) or to the RIGHT BUNDLE BRANCH OF HIS (nodofascicular accessory pathway).

Synonyms(7)

Synonym
Nodoventricular Mahaim-Type Pre-Excitation
Pre-Excitation, Mahaim-Type
Mahaim-Type Pre-Excitation
Mahaim-Type Pre-Excitation, Nodofascicular
Mahaim-Type Pre-Excitation, Nodoventricular
Mahaim-Type Preexcitation
Nodofascicular Mahaim-Type Pre-Excitation

Research

Studies (16)

TimeframeStudies, This Condition (%)All Conditions %
pre-19904 (25.00)23.3326
1990's6 (37.50)12.5806
2000's3 (18.75)18.1394
2010's3 (18.75)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
verapamil0low30
cimetidine0low10
disopyramide0low10
flecainide0low10
procainamide0low10
adenosine0low80
ajmaline0low20

Protein Targets (224)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, Membrane lipoprotein tmpC0011
Chain A, Membrane lipoprotein tmpC0011
Chain A, Membrane lipoprotein tmpC0011
Chain A, Structure of PAE2307 in complex with adenosine0011
Chain B, Structure of PAE2307 in complex with adenosine0011
Chain A, ADENOSINE RECEPTOR A2A0101
Chain A, ADENOSINE RECEPTOR A2A0101
Chain A, tRNA (guanine-N(1)-)-methyltransferase0011
Chain A, Uncharacterized protein MJ08830011
AR protein5005
signal transducer and activator of transcription 6, interleukin-4 induced1001
regulator of G-protein signaling 43003
glucocorticoid receptor [Homo sapiens]2002
retinoid X nuclear receptor alpha1001
estrogen nuclear receptor alpha6006
NPYLR7B0011
arylsulfatase A3003
IDH11001
Histone H2A.x1001
glycogen synthase kinase-3 beta isoform 10011
mitogen-activated protein kinase 12002
flap endonuclease 12002
nuclear receptor ROR-gamma isoform 11001
peripheral myelin protein 222002
survival motor neuron protein isoform d2002
high affinity choline transporter 1 isoform a0101
Sodium/nucleoside cotransporter 10202
Calcium dependent protein kinase0101
Mitogen-activated protein kinase kinase kinase 70011
Sodium/nucleoside cotransporter 20202
Voltage-dependent calcium channel gamma-2 subunit1001
Rap guanine nucleotide exchange factor 31001
Purine nucleoside phosphorylase0101
Epidermal growth factor receptor0101
Phosphoglycerate kinase 1 0101
Adenosine deaminase0001
Avidin0011
Adenosine deaminase0001
Glyceraldehyde-3-phosphate dehydrogenase0202
Receptor tyrosine-protein kinase erbB-20101
Insulin receptor0001
Phosphoglycerate kinase 20101
Heat shock protein HSP 90-alpha0112
Platelet-derived growth factor receptor beta0001
Adenosine receptor A30225
Heat shock 70 kDa protein 1A 0101
Heat shock cognate 71 kDa protein0011
Fibroblast growth factor receptor 10001
Inosine-5'-monophosphate dehydrogenase 20101
Endoplasmin0112
Glutamate receptor 21001
Inosine-5'-monophosphate dehydrogenase 1 0101
Fibroblast growth factor receptor 20001
Fibroblast growth factor receptor 40001
Fibroblast growth factor receptor 30001
Streptavidin0011
Adenosylhomocysteinase0001
Adenosine receptor A10112
Adenosine receptor A30101
Adenosine receptor A2a0124
Adenosine receptor A2b0012
Adenosine receptor A2b0112
Adenylate kinase 2, mitochondrial0101
Adenosine receptor A10225
Adenosine receptor A2a0112
Adenylate kinase isoenzyme 1 0101
Phosphatidylinositol 4-kinase alpha0203
Adenosine receptor A10011
Adenosine kinase0001
Adenosine deaminase 0001
Equilibrative nucleoside transporter 20202
Phosphatidylinositol 4-kinase type 2-beta0203
Histone-lysine N-methyltransferase, H3 lysine-79 specific0101
Equilibrative nucleoside transporter 10202
Phosphatidylinositol 4-kinase type 2-alpha0203
Solute carrier family 28 member 30202
Adenosine kinase0102
Phosphatidylinositol 4-kinase beta0203
5-methylthioadenosine/S-adenosylhomocysteine deaminase0001
Adenosine transporter 10001
interleukin 81001
phosphopantetheinyl transferase1001
thyroid stimulating hormone receptor2002
progesterone receptor2002
estrogen-related nuclear receptor alpha1001
G2002
cytochrome P450 2D62002
vitamin D (1,25- dihydroxyvitamin D3) receptor1001
alpha-galactosidase1001
euchromatic histone-lysine N-methyltransferase 23003
cytochrome P450 2C19 precursor2002
geminin2002
DNA polymerase kappa isoform 12002
cytochrome P450 3A4 isoform 11001
M-phase phosphoprotein 81001
muscarinic acetylcholine receptor M12002
lamin isoform A-delta104004
Solute carrier family 22 member 10202
Gamma-aminobutyric acid receptor subunit pi1001
Solute carrier family 22 member 20405
Solute carrier family 22 member 1 0607
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
Solute carrier family 22 member 60202
Solute carrier family 22 member 20202
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Bile salt export pump0505
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 2002
Cellular tumor antigen p531001
ATP-dependent translocase ABCB10202
ATP-dependent translocase ABCB103111
Cytochrome P450 3A40202
Cytochrome P450 2D60101
Cytochrome P450 2C9 0303
Gamma-aminobutyric acid receptor subunit beta-11001
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Potassium-transporting ATPase alpha chain 10101
ATP-dependent translocase ABCB10203
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Histamine H2 receptor0404
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Gamma-aminobutyric acid receptor subunit alpha-61001
Histamine H1 receptor0011
Histamine H2 receptor0213
Potassium-transporting ATPase subunit beta0101
Cytochrome P450 2J20303
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
Aldehyde oxidase0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 10505
Multidrug and toxin extrusion protein 20202
Solute carrier family 22 member 80203
GABA theta subunit1001
Inositol hexakisphosphate kinase 12002
Canalicular multispecific organic anion transporter 10404
Multidrug and toxin extrusion protein 10202
Gamma-aminobutyric acid receptor subunit epsilon1001
Histamine H4 receptor0101
Solute carrier family 22 member 110101
Solute carrier family 22 member 20505
Solute carrier family 22 member 40202
Solute carrier family 22 member 80202
cytochrome P450 2C9, partial2002
ATP-dependent phosphofructokinase2002
acetylcholinesterase1001
cytochrome P450 family 3 subfamily A polypeptide 43003
nonstructural protein 11001
activating transcription factor 62002
Bloom syndrome protein isoform 11001
peripheral myelin protein 22 isoform 11001
thyroid hormone receptor beta isoform a1001
potassium voltage-gated channel subfamily H member 2 isoform d3003
importin subunit beta-1 isoform 11001
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
histone acetyltransferase KAT2A isoform 11001
Voltage-dependent L-type calcium channel subunit alpha-1F0404
5-hydroxytryptamine receptor 70202
Spike glycoprotein2002
Voltage-dependent L-type calcium channel subunit alpha-1D 0404
Potassium voltage-gated channel subfamily H member 20404
Voltage-dependent L-type calcium channel subunit alpha-1S0404
Voltage-dependent L-type calcium channel subunit alpha-1C0404
TDP1 protein3003
EWS/FLI fusion protein2002
thyroid hormone receptor beta isoform 22002
Potassium voltage-gated channel subfamily A member 50101
Potassium voltage-gated channel subfamily A member 10101
Sodium channel protein type 5 subunit alpha0202
Potassium voltage-gated channel subfamily D member 20101
GLI family zinc finger 32002
aldehyde dehydrogenase 1 family, member A11001
Sterol O-acyltransferase 10101
Solute carrier family 22 member 30101
Acetylcholinesterase0202
Acetylcholinesterase 0101
DNA (cytosine-5)-methyltransferase 10101
Sterol O-acyltransferase 10101
DNA (cytosine-5)-methyltransferase 3-like0101
DNA (cytosine-5)-methyltransferase 3A0101
glp-1 receptor, partial1001
thioredoxin reductase1001
nuclear receptor subfamily 1, group I, member 31001
pregnane X nuclear receptor1001
glucocerebrosidase1001
peroxisome proliferator activated receptor gamma1001
thyroid stimulating hormone receptor1001
lysosomal alpha-glucosidase preproprotein1001
huntingtin isoform 21001
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Bile salt export pump0101
5-hydroxytryptamine receptor 40202
Albumin0011
Glycoprotein0101
Muscarinic acetylcholine receptor M20011
Alpha-2A adrenergic receptor0202
Cytochrome P450 2C80101
5-hydroxytryptamine receptor 1A0202
Catechol O-methyltransferase0101
Potassium voltage-gated channel subfamily A member 30101
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
5-hydroxytryptamine receptor 1B0202
Sodium-dependent serotonin transporter0202
Delta-type opioid receptor0101
Multidrug resistance-associated protein 1 0214
Mu-type opioid receptor0101
D(3) dopamine receptor0202
Kappa-type opioid receptor0101
5-hydroxytryptamine receptor 2B0202
D(2) dopamine receptor0101
Ataxin-21001
Chloroquine resistance transporter0101
Broad substrate specificity ATP-binding cassette transporter ABCG20112
Solute carrier organic anion transporter family member 1B10202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]