integrin alphaX-beta2 complex
Definition
Target type: cellularcomponent
An integrin complex that comprises one alphaX subunit and one beta2 subunit. [PMID:12297042]
The integrin alphaX-beta2 complex, also known as CD11c/CD18 or Mac-1, is a heterodimeric transmembrane receptor expressed primarily on leukocytes. It plays a critical role in leukocyte adhesion, migration, and signaling. The cellular component of this complex can be described as follows:
- **Extracellular domain:** The extracellular domain of the complex consists of two subunits, alphaX (CD11c) and beta2 (CD18), each containing multiple domains. The alphaX subunit has an I domain, a beta-propeller domain, a thigh domain, a calf-1 domain, a calf-2 domain, and a transmembrane domain. The beta2 subunit comprises a beta-propeller domain, a PSI domain, a hybrid domain, a transmembrane domain, and a cytoplasmic tail. The I domain of alphaX mediates binding to specific ligands, such as iC3b, fibrinogen, and ICAM-1.
- **Transmembrane domain:** The transmembrane domains of both alphaX and beta2 subunits anchor the complex to the plasma membrane. These domains are characterized by hydrophobic amino acid residues that interact with the lipid bilayer.
- **Cytoplasmic domain:** The cytoplasmic domains of alphaX and beta2 subunits play a crucial role in signal transduction. The beta2 subunit cytoplasmic domain interacts with various intracellular signaling molecules, including talin, kindlin, and PI3K. These interactions facilitate the activation of downstream signaling pathways involved in cell adhesion, migration, and activation.
Overall, the cellular component of integrin alphaX-beta2 complex is a highly complex structure with multiple domains and interacting partners. These features allow for the versatile functions of this receptor in leukocyte biology.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Integrin beta-2 | An integrin beta-2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P05107] | Homo sapiens (human) |
Compounds (11)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| indole | indole; polycyclic heteroarene | Escherichia coli metabolite | |
| 1,4-benzodioxan | 1,4-benzodioxan: structure in first source | ||
| 1-methylindole | 1-methylindole: SKATOLE refers to 3-methylindole; RN given refers to parent cpd; structure methylindole : Any member of the class of indoles carrying one or more methyl substituents. | ||
| lovastatin | lovastatin : A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom). Lovastatin: A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver. | delta-lactone; fatty acid ester; hexahydronaphthalenes; polyketide; statin (naturally occurring) | anticholesteremic drug; antineoplastic agent; Aspergillus metabolite; prodrug |
| chlorfenethazine | chlorfenethazine: RN given refers to parent cpd; synonym elroquil refers to HCl; structure | phenothiazines | |
| 2-bromohippuric acid | |||
| benzotript | benzotript: anti-gastrinic; active group is amide; structure | ||
| birt 377 | |||
| a 286982 | A 286982: inhibits the interaction between leukocyte function-associated antigen-1 and intracellular adhesion molecule-1; structure in first source | ||
| bio 1211 | BIO 1211: integrin alpha4beta1 inhibitor; structure in first source | ||
| sar 1118 | lifitegrast : An N-acyl-L-alpha-amino acid obtained by formal condensation of the carboxy group of N-[2-(1-benzofuran-6-carbonyl)]-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid with the amino group of 3-(methanesulfonyl)-L-phenylalanine. Used for treatment of keratoconjunctivitis sicca (dry eye syndrome). lifitegrast: An LFA-1 (LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1) antagonist that is used in the treatment of DRY EYE SYNDROMES. | 1-benzofurans; isoquinolines; L-phenylalanine derivative; N-acyl-L-alpha-amino acid; sulfone | anti-inflammatory drug; lymphocyte function-associated antigen-1 antagonist |