Target type: cellularcomponent
An integrin complex that comprises one alphaM subunit and one beta2 subunit. [PMID:12297042]
The integrin alphaM-beta2 complex, also known as Mac-1 or CD11b/CD18, is a heterodimeric transmembrane receptor expressed on the surface of various immune cells, including neutrophils, macrophages, monocytes, and natural killer cells. The complex is composed of two subunits: the alphaM (CD11b) subunit and the beta2 (CD18) subunit. Both subunits are type I transmembrane proteins with large extracellular domains, transmembrane domains, and short cytoplasmic tails.
The extracellular domain of the alphaM subunit is responsible for ligand binding. It consists of three domains: a beta-propeller domain, a thigh domain, and a calf-2 domain. The beta-propeller domain, located at the N-terminus, is responsible for binding to various ligands, including complement component iC3b, fibrinogen, and intercellular adhesion molecule-1 (ICAM-1). The thigh domain connects the beta-propeller domain to the calf-2 domain, which is involved in the interaction with the beta2 subunit.
The extracellular domain of the beta2 subunit also contains multiple domains, including a beta-propeller domain, a hybrid domain, and a PSI domain. The beta-propeller domain interacts with the calf-2 domain of the alphaM subunit, forming the heterodimer. The hybrid domain and PSI domain are involved in the regulation of integrin activation.
The cytoplasmic tails of both subunits are relatively short and interact with various intracellular signaling molecules, including cytoskeletal proteins, kinases, and phosphatases. These interactions are essential for the regulation of integrin activation and downstream signaling.
The alphaM-beta2 complex plays a crucial role in various immune processes, including leukocyte adhesion, migration, phagocytosis, and immune cell activation. It is involved in the recognition and binding of pathogens, the recruitment of immune cells to sites of inflammation, and the activation of downstream signaling pathways that mediate immune responses.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Integrin beta-2 | An integrin beta-2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P05107] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| indole | indole; polycyclic heteroarene | Escherichia coli metabolite | |
| 1,4-benzodioxan | 1,4-benzodioxan: structure in first source | ||
| 1-methylindole | 1-methylindole: SKATOLE refers to 3-methylindole; RN given refers to parent cpd; structure methylindole : Any member of the class of indoles carrying one or more methyl substituents. | ||
| lovastatin | lovastatin : A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom). Lovastatin: A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver. | delta-lactone; fatty acid ester; hexahydronaphthalenes; polyketide; statin (naturally occurring) | anticholesteremic drug; antineoplastic agent; Aspergillus metabolite; prodrug |
| chlorfenethazine | chlorfenethazine: RN given refers to parent cpd; synonym elroquil refers to HCl; structure | phenothiazines | |
| 2-bromohippuric acid | |||
| benzotript | benzotript: anti-gastrinic; active group is amide; structure | ||
| birt 377 | |||
| a 286982 | A 286982: inhibits the interaction between leukocyte function-associated antigen-1 and intracellular adhesion molecule-1; structure in first source | ||
| bio 1211 | BIO 1211: integrin alpha4beta1 inhibitor; structure in first source | ||
| sar 1118 | lifitegrast : An N-acyl-L-alpha-amino acid obtained by formal condensation of the carboxy group of N-[2-(1-benzofuran-6-carbonyl)]-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid with the amino group of 3-(methanesulfonyl)-L-phenylalanine. Used for treatment of keratoconjunctivitis sicca (dry eye syndrome). lifitegrast: An LFA-1 (LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1) antagonist that is used in the treatment of DRY EYE SYNDROMES. | 1-benzofurans; isoquinolines; L-phenylalanine derivative; N-acyl-L-alpha-amino acid; sulfone | anti-inflammatory drug; lymphocyte function-associated antigen-1 antagonist |