ICAM-3 receptor activity
Definition
Target type: molecularfunction
Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues. [GOC:ai, GOC:signaling, ISBN:0198506732, PMID:7515813]
ICAM-3 receptor activity, also known as CD50 receptor activity, plays a crucial role in cell-cell adhesion and immune system regulation. ICAM-3, a member of the immunoglobulin superfamily, is expressed on leukocytes and endothelial cells and functions as a ligand for leukocyte function-associated antigen-1 (LFA-1), a heterodimeric integrin found on various immune cells. The interaction between ICAM-3 and LFA-1 mediates adhesion and signaling events that are essential for immune responses.
This interaction contributes to various aspects of immune function, including:
1. Leukocyte migration and trafficking: ICAM-3 engagement with LFA-1 on leukocytes facilitates their migration across endothelial barriers, allowing them to reach sites of inflammation and infection. This process involves a series of steps, including rolling, firm adhesion, and transmigration, all of which are influenced by ICAM-3-LFA-1 interactions.
2. T cell activation and differentiation: ICAM-3-LFA-1 interactions play a critical role in T cell activation and differentiation. By providing a stable adhesion platform, ICAM-3 promotes the formation of the immunological synapse between T cells and antigen-presenting cells (APCs), enabling efficient signal transduction for T cell activation.
3. Immune surveillance and homeostasis: ICAM-3 also contributes to immune surveillance by facilitating the interaction of leukocytes with other cells, including dendritic cells and macrophages. This interaction helps to regulate immune responses and maintain immune homeostasis.
The molecular function of ICAM-3 receptor activity is complex and involves multiple signaling pathways. Upon ICAM-3-LFA-1 binding, intracellular signaling cascades are activated, leading to changes in cell morphology, cytoskeletal rearrangements, and gene expression. These events ultimately contribute to the diverse biological functions of ICAM-3 in immune regulation.'
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Proteins (3)
| Protein | Definition | Taxonomy |
|---|---|---|
| C-type lectin domain family 4 member M | A C-type lectin domain family 4 member M that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9H2X3] | Homo sapiens (human) |
| Integrin alpha-L | An integrin alpha-L that is encoded in the genome of human. [PRO:CNA, UniProtKB:P20701] | Homo sapiens (human) |
| Integrin beta-2 | An integrin beta-2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P05107] | Homo sapiens (human) |
Compounds (18)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| indole | indole; polycyclic heteroarene | Escherichia coli metabolite | |
| 1,4-benzodioxan | 1,4-benzodioxan: structure in first source | ||
| 1-methylindole | 1-methylindole: SKATOLE refers to 3-methylindole; RN given refers to parent cpd; structure methylindole : Any member of the class of indoles carrying one or more methyl substituents. | ||
| lovastatin | lovastatin : A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom). Lovastatin: A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver. | delta-lactone; fatty acid ester; hexahydronaphthalenes; polyketide; statin (naturally occurring) | anticholesteremic drug; antineoplastic agent; Aspergillus metabolite; prodrug |
| chlorfenethazine | chlorfenethazine: RN given refers to parent cpd; synonym elroquil refers to HCl; structure | phenothiazines | |
| methyl mannoside, (alpha-d)-isomer | methyl alpha-D-mannoside : A methyl mannoside having alpha-configuration at the anomeric centre. methylmannoside: RN given refers to (D)-isomer; see also record for 3-O-methylmannose | alpha-D-mannoside; methyl mannoside | |
| 2-bromohippuric acid | |||
| cucurbitacin r | 23,24-dihydrocucurbitacin D : A 23,24-dihydrocucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at position 5. cucurbitacin R: from Cayaponia tayuya roots; structure in first source | 23,24-dihydrocucurbitacin; secondary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone | |
| fixb protein, e coli | alpha-D-mannose : D-Mannopyranose having alpha-configuration at the anomeric centre. alpha-D-mannoside : Any mannoside in which the anomeric centre has alpha-configuration. muscarinic toxin 2: muscarinic agonists from Dendroaspis angusticeps; amino acid sequence given in first source | D-mannopyranose | epitope |
| 4-quinolone-3-carboxylic acid | 4-quinolone-3-carboxylic acid: structure in first source | ||
| benzotript | benzotript: anti-gastrinic; active group is amide; structure | ||
| cucurbitacin d | cucurbitacin D : A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23. cucurbitacin D: toxic constituent in edible gourd; see also records for cucurbitacins & specific cucurbitacins | cucurbitacin; secondary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone | |
| nsc 106399 | cucurbitacin E : A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 1, 5 and 23. cucurbitacin E: RN refers to (9beta,10alpha,16alpha,23E)-isomer; structure given in first source | cucurbitacin; tertiary alpha-hydroxy ketone | |
| cucurbitacin i | cucurbitacin I : A cucurbitacin that is 9,10,14-trimethyl-4,9-cyclo-9,10-secocholesta-2,5,23-triene substituted by hydroxy groups at positions 2, 16, 20 and 25 and oxo groups at positions 1, 11 and 22. cucurbitacin I: toxic constituent in edible gourd; see also records for cucurbitacins & specific cucurbitacins | cucurbitacin; tertiary alpha-hydroxy ketone | antineoplastic agent; plant metabolite |
| birt 377 | |||
| a 286982 | A 286982: inhibits the interaction between leukocyte function-associated antigen-1 and intracellular adhesion molecule-1; structure in first source | ||
| bio 1211 | BIO 1211: integrin alpha4beta1 inhibitor; structure in first source | ||
| sar 1118 | lifitegrast : An N-acyl-L-alpha-amino acid obtained by formal condensation of the carboxy group of N-[2-(1-benzofuran-6-carbonyl)]-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid with the amino group of 3-(methanesulfonyl)-L-phenylalanine. Used for treatment of keratoconjunctivitis sicca (dry eye syndrome). lifitegrast: An LFA-1 (LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1) antagonist that is used in the treatment of DRY EYE SYNDROMES. | 1-benzofurans; isoquinolines; L-phenylalanine derivative; N-acyl-L-alpha-amino acid; sulfone | anti-inflammatory drug; lymphocyte function-associated antigen-1 antagonist |