| Protein | Potency Measurements | Inhibition Measurements | Activation Measurements | Drugs |
|---|
| 5-hydroxytryptamine receptor 2C | 0 | 2 | 2 | 4 |
| 5-hydroxytryptamine receptor 2A | 0 | 2 | 3 | 5 |
| 5-hydroxytryptamine receptor 1A | 0 | 1 | 2 | 3 |
| Sodium-dependent noradrenaline transporter | 0 | 2 | 0 | 2 |
| Sodium-dependent dopamine transporter | 0 | 0 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | 0 | 1 | 2 | 3 |
| 5-hydroxytryptamine receptor 1D | 0 | 1 | 2 | 3 |
| 5-hydroxytryptamine receptor 1F | 0 | 1 | 2 | 3 |
| 5-hydroxytryptamine receptor 2B | 0 | 2 | 2 | 4 |
| 5-hydroxytryptamine receptor 6 | 0 | 0 | 2 | 2 |
| Sodium-dependent serotonin transporter | 0 | 2 | 2 | 4 |
| Sodium-dependent serotonin transporter | 0 | 2 | 1 | 3 |
| 5-hydroxytryptamine receptor 7 | 0 | 0 | 2 | 2 |
| 5-hydroxytryptamine receptor 5A | 0 | 0 | 2 | 2 |
| 5-hydroxytryptamine receptor 5B | 0 | 0 | 2 | 2 |
| 5-hydroxytryptamine receptor 3A | 0 | 0 | 2 | 2 |
| Sodium-dependent dopamine transporter | 0 | 2 | 0 | 2 |
| 5-hydroxytryptamine receptor 4 | 0 | 0 | 2 | 2 |
| 5-hydroxytryptamine receptor 3B | 0 | 0 | 2 | 2 |
| PPM1D protein | 1 | 0 | 0 | 1 |
| Acetylcholinesterase | 0 | 1 | 0 | 1 |
| L-lactate dehydrogenase A chain | 0 | 1 | 0 | 1 |
| Interferon beta | 2 | 0 | 0 | 2 |
| Cytochrome P450 1A1 | 0 | 1 | 0 | 1 |
| Cytochrome P450 1A2 | 0 | 1 | 0 | 1 |
| Cytochrome P450 2C11 | 0 | 1 | 0 | 1 |
| Cytochrome P450 3A4 | 0 | 1 | 0 | 1 |
| 5-hydroxytryptamine receptor 1A | 0 | 0 | 1 | 1 |
| Cytochrome P450 2D6 | 0 | 2 | 0 | 2 |
| Cytochrome P450 2A6 | 0 | 1 | 0 | 1 |
| Cytochrome P450 2C9 | 0 | 2 | 0 | 2 |
| Steroid 17-alpha-hydroxylase/17,20 lyase | 0 | 1 | 0 | 1 |
| Fatty acid-binding protein, liver | 0 | 1 | 0 | 1 |
| Alpha-2B adrenergic receptor | 0 | 1 | 0 | 1 |
| Alpha-2C adrenergic receptor | 0 | 1 | 0 | 1 |
| Cannabinoid receptor 1 | 0 | 1 | 0 | 1 |
| Cytochrome P450 2B6 | 0 | 1 | 0 | 1 |
| Cytochrome P450 3A5 | 0 | 1 | 0 | 1 |
| Cannabinoid receptor 1 | 0 | 1 | 0 | 2 |
| D(1A) dopamine receptor | 0 | 1 | 0 | 1 |
| Cytochrome P450 3A7 | 0 | 1 | 0 | 1 |
| 5-hydroxytryptamine receptor 2C | 0 | 1 | 0 | 1 |
| Caspase-1 | 0 | 0 | 1 | 1 |
| Cytochrome P450 2C19 | 0 | 1 | 0 | 1 |
| Cannabinoid receptor 2 | 0 | 1 | 1 | 3 |
| Mu-type opioid receptor | 0 | 3 | 1 | 5 |
| Peroxisome proliferator-activated receptor gamma | 0 | 0 | 1 | 1 |
| Delta-type opioid receptor | 0 | 3 | 1 | 5 |
| Kappa-type opioid receptor | 0 | 3 | 2 | 6 |
| Spike glycoprotein | 2 | 0 | 0 | 2 |
| Cholinesterase | 0 | 1 | 0 | 1 |
| N-acylethanolamine-hydrolyzing acid amidase | 0 | 1 | 0 | 1 |
| Cytochrome P450 1B1 | 0 | 1 | 0 | 1 |
| Heat sensitive channel TRPV3 | 0 | 1 | 1 | 2 |
| Sigma intracellular receptor 2 | 0 | 1 | 0 | 1 |
| Transient receptor potential cation channel subfamily A member 1 | 0 | 1 | 1 | 2 |
| Transient receptor potential cation channel subfamily V member 1 | 0 | 1 | 1 | 2 |
| Transient receptor potential cation channel subfamily M member 8 | 0 | 1 | 0 | 1 |
| Transient receptor potential cation channel subfamily V member 4 | 0 | 1 | 1 | 2 |
| Transient receptor potential cation channel subfamily V member 2 | 0 | 1 | 1 | 2 |
| G-protein coupled receptor 55 | 0 | 0 | 1 | 1 |
| Diacylglycerol lipase-alpha | 0 | 1 | 0 | 1 |
| Histamine H3 receptor | 0 | 1 | 0 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | 1 | 0 | 0 | 1 |
| Chain A, BCL-2-RELATED PROTEIN A1 | 0 | 0 | 1 | 1 |
| Chain A, Cruzipain | 1 | 0 | 0 | 1 |
| Luciferase | 1 | 0 | 0 | 1 |
| acid sphingomyelinase | 1 | 0 | 0 | 1 |
| interleukin 8 | 1 | 0 | 0 | 1 |
| acetylcholinesterase | 1 | 0 | 0 | 1 |
| PAX8 | 0 | 0 | 0 | 1 |
| glp-1 receptor, partial | 1 | 0 | 0 | 1 |
| 15-lipoxygenase, partial | 1 | 0 | 0 | 1 |
| pregnane X receptor | 1 | 0 | 0 | 1 |
| phosphopantetheinyl transferase | 1 | 0 | 0 | 1 |
| hypoxia-inducible factor 1 alpha subunit | 1 | 0 | 0 | 1 |
| RAR-related orphan receptor gamma | 2 | 0 | 0 | 2 |
| SMAD family member 2 | 1 | 0 | 0 | 1 |
| USP1 protein, partial | 1 | 0 | 0 | 1 |
| SMAD family member 3 | 1 | 0 | 0 | 1 |
| TDP1 protein | 1 | 0 | 0 | 1 |
| GLI family zinc finger 3 | 1 | 0 | 0 | 1 |
| AR protein | 1 | 0 | 0 | 1 |
| caspase 7, apoptosis-related cysteine protease | 1 | 0 | 0 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 1 | 0 | 0 | 1 |
| PINK1 | 1 | 0 | 0 | 1 |
| thyroid stimulating hormone receptor | 1 | 0 | 0 | 1 |
| estrogen receptor 2 (ER beta) | 1 | 0 | 0 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | 1 | 0 | 0 | 1 |
| progesterone receptor | 1 | 0 | 0 | 1 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | 1 | 0 | 0 | 1 |
| glucocorticoid receptor [Homo sapiens] | 1 | 0 | 0 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | 1 | 0 | 0 | 1 |
| retinoid X nuclear receptor alpha | 1 | 0 | 0 | 1 |
| estrogen-related nuclear receptor alpha | 2 | 0 | 0 | 2 |
| farnesoid X nuclear receptor | 1 | 0 | 0 | 1 |
| pregnane X nuclear receptor | 2 | 0 | 0 | 2 |
| estrogen nuclear receptor alpha | 3 | 0 | 0 | 3 |
| G | 1 | 0 | 0 | 1 |
| cytochrome P450 2D6 | 2 | 0 | 0 | 2 |
| 67.9K protein | 1 | 0 | 0 | 1 |
| glucocerebrosidase | 1 | 0 | 0 | 1 |
| Parkin | 1 | 0 | 0 | 1 |
| peroxisome proliferator-activated receptor delta | 1 | 0 | 0 | 1 |
| peroxisome proliferator activated receptor gamma | 1 | 0 | 0 | 1 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | 1 | 0 | 0 | 1 |
| heat shock protein 90 | 0 | 0 | 1 | 1 |
| caspase-3 | 1 | 0 | 0 | 1 |
| IDH1 | 1 | 0 | 0 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | 1 | 0 | 0 | 1 |
| calcineurin A1, putative | 0 | 0 | 1 | 1 |
| aryl hydrocarbon receptor | 1 | 0 | 0 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | 1 | 0 | 0 | 1 |
| thyroid stimulating hormone receptor | 1 | 0 | 0 | 1 |
| activating transcription factor 6 | 1 | 0 | 0 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | 1 | 0 | 0 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | 1 | 0 | 0 | 1 |
| Histone H2A.x | 1 | 0 | 0 | 1 |
| cytochrome P450 2D6 isoform 1 | 1 | 0 | 0 | 1 |
| hepatocyte nuclear factor 4-alpha isoform 2 | 0 | 1 | 0 | 1 |
| cellular tumor antigen p53 isoform a | 1 | 0 | 0 | 1 |
| cytochrome P450 2C19 precursor | 1 | 0 | 0 | 1 |
| cytochrome P450 2C9 precursor | 1 | 0 | 0 | 1 |
| perilipin-5 | 0 | 1 | 0 | 1 |
| thyroid hormone receptor beta isoform a | 2 | 0 | 0 | 2 |
| perilipin-1 | 0 | 1 | 0 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | 1 | 0 | 0 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | 1 | 0 | 0 | 1 |
| transcriptional regulator ERG isoform 3 | 1 | 0 | 0 | 1 |
| thyroid hormone receptor beta isoform 2 | 1 | 0 | 0 | 1 |
| heat shock protein beta-1 | 1 | 0 | 0 | 1 |
| huntingtin isoform 2 | 1 | 0 | 0 | 1 |
| importin subunit beta-1 isoform 1 | 1 | 0 | 0 | 1 |
| mitogen-activated protein kinase 1 | 1 | 0 | 0 | 1 |
| ubiquitin-conjugating enzyme E2 N | 0 | 1 | 0 | 1 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | 1 | 0 | 0 | 1 |
| flap endonuclease 1 | 1 | 0 | 0 | 1 |
| protein AF-9 isoform a | 0 | 0 | 0 | 1 |
| snurportin-1 | 1 | 0 | 0 | 1 |
| melanocortin receptor 4 | 0 | 1 | 0 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | 1 | 0 | 0 | 1 |
| CAAX prenyl protease | 0 | 0 | 0 | 1 |
| urokinase-type plasminogen activator precursor | 1 | 0 | 0 | 1 |
| plasminogen precursor | 1 | 0 | 0 | 1 |
| bcl-2-related protein A1 | 0 | 1 | 0 | 1 |
| urokinase plasminogen activator surface receptor precursor | 1 | 0 | 0 | 1 |
| nuclear receptor ROR-gamma isoform 1 | 1 | 0 | 0 | 1 |
| geminin | 1 | 0 | 0 | 1 |
| 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a | 0 | 1 | 0 | 1 |
| DNA polymerase kappa isoform 1 | 1 | 0 | 0 | 1 |
| peripheral myelin protein 22 | 1 | 0 | 0 | 1 |
| cytochrome P450 3A4 isoform 1 | 1 | 0 | 0 | 1 |
| glycogen synthase kinase-3 alpha | 0 | 0 | 0 | 1 |
| hexokinase HKDC1 | 0 | 1 | 0 | 1 |
| DNA repair protein RAD52 homolog isoform a | 0 | 0 | 0 | 1 |
| bcl-2-like protein 11 isoform 1 | 0 | 0 | 1 | 1 |
| lethal factor (plasmid) | 1 | 0 | 0 | 1 |
| lamin isoform A-delta10 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | 1 | 0 | 0 | 1 |
| Synaptojanin-2 | 0 | 1 | 0 | 1 |
| Solute carrier family 22 member 2 | 0 | 1 | 0 | 1 |
| Solute carrier family 22 member 1 | 0 | 1 | 0 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | 1 | 0 | 0 | 1 |
| Synaptojanin-1 | 0 | 1 | 0 | 1 |
| Solute carrier family 22 member 3 | 0 | 1 | 0 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | 1 | 0 | 0 | 1 |
| Glutathione reductase, mitochondrial | 0 | 1 | 0 | 2 |
| HLA class I histocompatibility antigen, B alpha chain | 1 | 0 | 0 | 1 |
| Cellular tumor antigen p53 | 1 | 0 | 0 | 1 |
| Integrin beta-3 | 1 | 0 | 0 | 1 |
| 72 kDa type IV collagenase | 0 | 1 | 0 | 1 |
| Integrin alpha-IIb | 1 | 0 | 0 | 1 |
| Matrix metalloproteinase-9 | 0 | 1 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | 1 | 0 | 0 | 1 |
| Glutamate receptor 2 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | 1 | 0 | 0 | 1 |
| Trypanothione reductase | 0 | 1 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | 1 | 0 | 0 | 1 |
| Alpha-synuclein | 1 | 0 | 0 | 1 |
| Histamine H2 receptor | 1 | 0 | 0 | 1 |
| Nuclear receptor ROR-gamma | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | 1 | 0 | 0 | 1 |
| TAR DNA-binding protein 43 | 1 | 0 | 0 | 1 |
| Peroxisomal N(1)-acetyl-spermine/spermidine oxidase | 0 | 1 | 0 | 1 |
| Multidrug and toxin extrusion protein 2 | 0 | 1 | 0 | 1 |
| Rap guanine nucleotide exchange factor 4 | 1 | 0 | 0 | 1 |
| GABA theta subunit | 1 | 0 | 0 | 1 |
| Inositol hexakisphosphate kinase 1 | 1 | 0 | 0 | 1 |
| Multidrug and toxin extrusion protein 1 | 0 | 1 | 0 | 1 |
| ATPase family AAA domain-containing protein 5 | 1 | 0 | 0 | 1 |
| Ataxin-2 | 1 | 0 | 0 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | 1 | 0 | 0 | 1 |
| Spermine oxidase | 0 | 1 | 0 | 1 |
| cytochrome P450 2C9, partial | 1 | 0 | 0 | 1 |
| ATP-binding cassette sub-family C member 3 | 0 | 1 | 0 | 1 |
| Multidrug resistance-associated protein 4 | 0 | 1 | 0 | 1 |
| Bile salt export pump | 0 | 1 | 0 | 1 |
| Muscarinic acetylcholine receptor M1 | 0 | 1 | 0 | 1 |
| Muscarinic acetylcholine receptor M3 | 0 | 1 | 0 | 1 |
| Muscarinic acetylcholine receptor M4 | 0 | 1 | 0 | 1 |
| Muscarinic acetylcholine receptor M5 | 0 | 1 | 0 | 1 |
| Muscarinic acetylcholine receptor M2 | 0 | 1 | 0 | 1 |
| Histidine decarboxylase | 0 | 0 | 1 | 1 |
| D(3) dopamine receptor | 0 | 1 | 0 | 1 |
| Adenosine receptor A1 | 0 | 1 | 0 | 1 |
| Delta-type opioid receptor | 0 | 2 | 1 | 4 |
| Delta-type opioid receptor | 0 | 2 | 2 | 4 |
| Kappa-type opioid receptor | 0 | 1 | 0 | 2 |
| Mu-type opioid receptor | 0 | 2 | 2 | 4 |
| Kappa-type opioid receptor | 0 | 1 | 2 | 3 |
| Kappa-type opioid receptor | 0 | 2 | 1 | 3 |
| Mu-type opioid receptor | 0 | 1 | 0 | 2 |
| Cytochrome P450 2J2 | 0 | 1 | 0 | 1 |
| Mu-type opioid receptor | 0 | 2 | 1 | 3 |
| Sigma non-opioid intracellular receptor 1 | 0 | 1 | 0 | 1 |
| Beta-2 adrenergic receptor | 0 | 1 | 0 | 1 |
| Canalicular multispecific organic anion transporter 1 | 0 | 1 | 0 | 1 |
| Sigma non-opioid intracellular receptor 1 | 0 | 1 | 0 | 1 |
| UDP-glucuronosyltransferase 1A8 | 0 | 0 | 0 | 1 |
| Sigma non-opioid intracellular receptor 1 | 0 | 1 | 0 | 1 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |