Page last updated: 2024-09-27

Asplenia Syndrome

Congenital deformity in which the internal organs of the THORAX and the ABDOMEN are abnormally arranged across the mediolateral body axis.

Synonyms(14)

Synonym
Left Atrial Isomerism
Left Atrial Isomerism with Polysplenia
Asplenia Syndrome
Polysplenia Syndrome
Situs Ambiguus
Situs Ambiguus Viscerum
Situs Ambiguus with Asplenia
Situs Ambiguus with Polysplenia
Asplenia with Cardiovascular Anomalies
Visceral Heterotaxy
Heterotaxy Syndrome
Ivemark Syndrome
Right Atrial Isomerism with Asplenia
Right Atrial Isomerism

Research Excerpts

Overview

ExcerptReference
"Heterotaxy syndrome is characterized by abnormal symmetry and malposition of the thoracoabdominal organs and vessels."( Ellison, AM; Schinasi, DA, 2010)

Research

Studies (20)

TimeframeStudies, This Condition (%)All Conditions %
pre-19901 (5.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's17 (85.00)28.8240
2020's2 (10.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
acetaminophen0low10
aspirin0low10
sevoflurane0low10
framycetin0low10
gadolinium0low20
fluorodeoxyglucose f180low10
rocuronium0low10
cysteine0low10
atrial natriuretic factor0low10
natriuretic peptide, c-type0low10
novobiocin0low10
transforming growth factor beta0low10
sildenafil citrate0low10

Protein Targets (262)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
RAR-related orphan receptor gamma1001
ATAD5 protein, partial1001
GLS protein2002
Microtubule-associated protein tau1001
Smad31001
aldehyde dehydrogenase 1 family, member A13003
thyroid stimulating hormone receptor3003
nuclear receptor subfamily 1, group I, member 32002
progesterone receptor2002
EWS/FLI fusion protein3003
retinoic acid nuclear receptor alpha variant 13003
retinoid X nuclear receptor alpha1001
estrogen-related nuclear receptor alpha3003
estrogen nuclear receptor alpha5005
peroxisome proliferator activated receptor gamma1001
aryl hydrocarbon receptor1001
chromobox protein homolog 11001
thyroid hormone receptor beta isoform 21001
peripheral myelin protein 222002
cytochrome P450 3A4 isoform 11001
Gamma-aminobutyric acid receptor subunit pi1001
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
Solute carrier family 22 member 60202
Carbonic anhydrase 120102
UDP-glucuronosyltransferase 1A90001
Bile salt export pump0101
Voltage-dependent calcium channel gamma-2 subunit1001
Bile salt export pump0505
Cytochrome P450 2B10001
Cytochrome P450 1A10001
Carbonic anhydrase 10304
Carbonic anhydrase 20304
Myoglobin0101
Cytochrome P450 1A10012
Cytochrome P450 1A20001
Prostaglandin G/H synthase 10202
Carbonic anhydrase 30102
Cytochrome P450 3A40101
Cytochrome P450 2D60101
Cytochrome P450 2C9 0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Gamma-aminobutyric acid receptor subunit beta-11001
Sulfotransferase 1A1 0001
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
UDP-glucuronosyltransferase 1-60001
Glutamate receptor 21001
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Arachidonate 5-lipoxygenase-activating protein0101
UDP-glucuronosyltransferase 1A1 0001
Carbonic anhydrase 40102
Prostaglandin G/H synthase 10303
Carbonic anhydrase 60102
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Gamma-aminobutyric acid receptor subunit alpha-61001
Carbonic anhydrase 5A, mitochondrial0102
Prostaglandin G/H synthase 20203
Carbonic anhydrase 70102
Nuclear receptor ROR-gamma2002
Cytochrome P450 2J20101
Gamma-aminobutyric acid receptor subunit alpha-11102
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
Carbonic anhydrase 90102
GABA theta subunit1001
Canalicular multispecific organic anion transporter 10404
Carbonic anhydrase 150101
Carbonic anhydrase 130102
Gamma-aminobutyric acid receptor subunit epsilon1001
Carbonic anhydrase 140102
Carbonic anhydrase 5B, mitochondrial0102
toxin B0001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, 2-oxoglutarate Oxygenase1001
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 81001
thioredoxin reductase1001
AR protein2002
hypothetical protein, conserved1001
cytochrome P450 family 3 subfamily A polypeptide 42002
glucocorticoid receptor [Homo sapiens]3003
cytochrome P450 2D61001
glucocerebrosidase1001
peroxisome proliferator-activated receptor delta1001
Rac1 protein0011
IDH11001
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
euchromatic histone-lysine N-methyltransferase 21001
Bloom syndrome protein isoform 11001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
DNA polymerase iota isoform a (long)1001
DNA polymerase kappa isoform 11001
muscarinic acetylcholine receptor M11001
lethal factor (plasmid)1001
Prostaglandin-H2 D-isomerase0101
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Epidermal growth factor receptor0101
Fatty acid-binding protein, liver0101
Integrin beta-30101
Myeloperoxidase0101
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb0101
Glutathione hydrolase 1 proenzyme0101
Adenosine receptor A10101
Adenosine receptor A2a0101
Substance-P receptor0101
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Ras-related protein Rab-2A0011
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Sigma non-opioid intracellular receptor 10011
Sigma non-opioid intracellular receptor 10011
Atrial natriuretic peptide receptor 10011
Atrial natriuretic peptide receptor 1 0011
Menin0011
Lecithin retinol acyltransferase0101
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
Lethal factor0101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Protein Rev 0011
Aminoglycoside 3'-phosphotransferase 0001
Tyrosyl-DNA phosphodiesterase 10101
vitamin D (1,25- dihydroxyvitamin D3) receptor1001
activating transcription factor 61001
TDP1 protein1001
pregnane X nuclear receptor2002
Thioredoxin reductase 0101
Histone H2A.x1001
vitamin D3 receptor isoform VDRA1001
thyroid hormone receptor beta isoform a1001
mitogen-activated protein kinase 11001
geminin1001
muscleblind-like protein 1 isoform 11001
lamin isoform A-delta101001
Flavodoxin0001
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Cellular tumor antigen p531001
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
TAR DNA-binding protein 431001
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Lanosterol 14-alpha demethylase0101
Chain A, Gyrase0011
Genome polyprotein 0112
DNA gyrase subunit B0101
interferon gamma precursor0001
Albumin0022
Heat shock protein HSP 90-alpha0022
Heat shock protein HSP 90-beta0124
DNA gyrase subunit B0203
DNA gyrase subunit B0101
DNA gyrase subunit A0203
DNA gyrase subunit B0213
DNA topoisomerase 4 subunit A0101
Cell division inhibitor SulA0001
DNA topoisomerase 4 subunit B0101
DNA topoisomerase 4 subunit A0101
DNA gyrase subunit B0101
DNA topoisomerase 2-alpha0101
Heat shock protein HSP 900101
Angiotensin-converting enzyme 0101
DNA topoisomerase 4 subunit B0101
DNA gyrase subunit A0203
DNA gyrase subunit B0101
DNA gyrase subunit A0101
DNA topoisomerase 0101
Microtubule-associated proteins 1A/1B light chain 3B0213
Microtubule-associated proteins 1A/1B light chain 3A0213
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Spike glycoprotein1001
GLI family zinc finger 31001
G1001
nuclear receptor subfamily 1, group I, member 21001
potassium voltage-gated channel subfamily H member 2 isoform d1001
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Interferon beta1001
HLA class I histocompatibility antigen, B alpha chain 1001
Inositol hexakisphosphate kinase 11001
cytochrome P450 2C9, partial1001
Alpha-2A adrenergic receptor0101
60 kDa heat shock protein, mitochondrial0101
Alpha-1B adrenergic receptor0101
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Alpha-1D adrenergic receptor0101
Sodium-dependent serotonin transporter0101
Alpha-1A adrenergic receptor0101
10 kDa heat shock protein, mitochondrial0101
D-alanyl-D-alanine dipeptidase0101
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Transporter0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]