tertiary granule

Definition

Target type: cellularcomponent

A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells. [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036]

Tertiary granules are membrane-bound organelles found in the cytoplasm of neutrophils, a type of white blood cell. They are the largest of the three types of neutrophil granules (primary, secondary, and tertiary), and they are characterized by their content of hydrolytic enzymes, including gelatinase, collagenase, and cathepsin G. These enzymes are involved in the breakdown of extracellular matrix components, which allows neutrophils to migrate to sites of inflammation and infection. Tertiary granules also contain other proteins, such as lactoferrin, which binds iron and inhibits the growth of bacteria. The formation of tertiary granules is a complex process that involves the coordinated action of multiple proteins and enzymes. The granules mature over time, and their content changes as they progress through different stages of development. The exact composition and function of tertiary granules may vary depending on the type of neutrophil and the specific conditions under which they are formed.'
"

Proteins (1)

Compounds (1)