Proteins > Disintegrin and metalloproteinase domain-containing protein 17
Page last updated: 2024-08-07 12:46:33
Disintegrin and metalloproteinase domain-containing protein 17
[no definition available]
Synonyms
ADAM 17;
EC 3.4.24.86;
TNF-alpha convertase;
TNF-alpha-converting enzyme
Research
Bioassay Publications (4)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
Compounds (3)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| ik 682 | Sus scrofa (pig) | IC50 | 0.0010 | 1 | 1 |
| ik 682 | Sus scrofa (pig) | Ki | 0.0006 | 3 | 3 |
| bms-566394 | Sus scrofa (pig) | IC50 | 2.0011 | 3 | 4 |
| incb3619 | Sus scrofa (pig) | IC50 | 0.0140 | 1 | 1 |
Zinc enzymes in medicinal chemistry.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.Bioorganic & medicinal chemistry, , Oct-01, Volume: 16, Issue:19, 2008
Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships.Journal of medicinal chemistry, , Nov-07, Volume: 45, Issue:23, 2002
Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.Bioorganic & medicinal chemistry, , Oct-01, Volume: 16, Issue:19, 2008