tumor necrosis factor receptor superfamily binding

Definition

Target type: molecularfunction

Binding to a member of the tumor necrosis factor receptor superfamily. [GOC:add]

Tumor necrosis factor receptor superfamily binding is a molecular function that describes the interaction of proteins with members of the tumor necrosis factor receptor (TNFR) superfamily. This superfamily comprises a diverse group of transmembrane receptors involved in regulating a wide array of cellular processes, including inflammation, apoptosis, cell survival, proliferation, and differentiation.

TNFR superfamily members share a common structural motif, the cysteine-rich domain (CRD), which is responsible for ligand binding. This domain exhibits significant variability among different TNFR family members, allowing for specific interactions with their cognate ligands.

The binding of ligands to TNFR superfamily members triggers a complex signaling cascade that involves the recruitment of intracellular adaptor proteins and the activation of downstream signaling pathways. These pathways can lead to the activation of transcription factors, such as NF-κB and AP-1, which regulate the expression of target genes involved in various cellular responses.

The molecular function of TNFR superfamily binding plays a crucial role in immune regulation and defense against pathogens. It is also involved in the pathogenesis of various diseases, including cancer, autoimmune disorders, and inflammatory diseases. For instance, dysregulation of TNFR signaling is implicated in the development of rheumatoid arthritis, inflammatory bowel disease, and certain types of cancer.'
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Proteins (2)

Compounds (2)