Disintegrin and metalloproteinase domain-containing protein 8

A disintegrin and metalloproteinase domain-containing protein 8 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P78325]

Synonyms

ADAM 8;
EC 3.4.24.-;
Cell surface antigen MS2

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (1)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
incb3619	Homo sapiens (human)	IC50	1.0000	1	1

Enables

This protein enables 9 target(s):

Target	Category	Definition
serine-type endopeptidase activity	molecular function	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
calcium ion binding	molecular function	Binding to a calcium ion (Ca2+). [GOC:ai]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
metallopeptidase activity	molecular function	Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
zinc ion binding	molecular function	Binding to a zinc ion (Zn). [GOC:ai]
tumor necrosis factor receptor superfamily binding	molecular function	Binding to a member of the tumor necrosis factor receptor superfamily. [GOC:add]
immunoglobulin receptor binding	molecular function	Binding to one or more specific sites on an immunoglobulin receptor molecule. [GOC:BHF, GOC:vk]
metalloendopeptidase activity	molecular function	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]
cell adhesion molecule binding	molecular function	Binding to a cell adhesion molecule. [GOC:ai]

Located In

This protein is located in 11 target(s):

Target	Category	Definition
podosome	cellular component	An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm. [PMID:12837608, PMID:15890982]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cell surface	cellular component	The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
phagolysosome	cellular component	A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes. [GOC:mah, PMID:12388753, PMID:14733906]
dense core granule membrane	cellular component	The lipid bilayer surrounding a dense core granule. [GOC:mah]
specific granule membrane	cellular component	The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. [GOC:bf, PMID:7334549]
specific granule	cellular component	Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. [GOC:jl, ISBN:0721662544, PMID:7334549]
tertiary granule	cellular component	A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells. [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036]
tertiary granule membrane	cellular component	The lipid bilayer surrounding a tertiary granule. [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036]
ficolin-1-rich granule membrane	cellular component	The lipid bilayer surrounding a ficolin-1-rich granule. [GOC:mec, PMID:23650620]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
alpha9-beta1 integrin-ADAM8 complex	cellular component	A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM8. [PMID:16995821]

Involved In

This protein is involved in 30 target(s):

Target	Category	Definition
cell morphogenesis	biological process	The developmental process in which the size or shape of a cell is generated and organized. [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
angiogenesis	biological process	Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. [ISBN:0878932453]
leukocyte migration involved in inflammatory response	biological process	The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response. [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
positive regulation of acute inflammatory response	biological process	Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response. [GOC:add]
inflammatory response	biological process	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]
canonical NF-kappaB signal transduction	biological process	An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs). [GOC:bf, PMID:12773372, PMID:34659217]
positive regulation of epithelial to mesenchymal transition	biological process	Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. [GOC:BHF, GOC:dph, GOC:tb]
positive regulation of protein processing	biological process	Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage. [GOC:dph, GOC:mah, GOC:tb]
regulation of cell-cell adhesion	biological process	Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. [GOC:isa_complete]
extracellular matrix disassembly	biological process	A process that results in the breakdown of the extracellular matrix. [GOC:jid]
signal release	biological process	The process in which a signal is secreted or discharged into the extracellular medium from a cellular source. [GOC:mtg_signal]
positive regulation of T cell differentiation in thymus	biological process	Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus. [GOC:add, GOC:mah]
positive regulation of MAPK cascade	biological process	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. [GOC:go_curators]
negative regulation of neuron apoptotic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. [GOC:go_curators, GOC:mtg_apoptosis]
positive regulation of innate immune response	biological process	Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. [GOC:ebc]
positive regulation of bone resorption	biological process	Any process that activates or increases the frequency, rate or extent of bone resorption. [GOC:go_curators]
positive regulation of cell adhesion	biological process	Any process that activates or increases the frequency, rate or extent of cell adhesion. [GOC:go_curators]
lymphocyte chemotaxis	biological process	The directed movement of a lymphocyte in response to an external stimulus. [GOC:hjd, GOC:jid, PMID:12391252]
positive regulation of protein secretion	biological process	Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. [GOC:ai]
positive regulation of membrane protein ectodomain proteolysis	biological process	Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis. [GOC:ai]
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	biological process	Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction. [GOC:ai]
positive regulation of thymocyte apoptotic process	biological process	Any process that activates or increases the frequency, rate or extent of thymocyte death by apoptotic process. [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196]
cellular response to hypoxia	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:mah]
cell-cell adhesion	biological process	The attachment of one cell to another cell via adhesion molecules. [GOC:dos]
positive regulation of tumor necrosis factor (ligand) superfamily member 11 production	biological process	Any process that activates or increases the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production. [GOC:BHF, GOC:mah]
positive regulation of neutrophil extravasation	biological process	Any process that activates or increases the frequency, rate or extent of neutrophil extravasation. [GOC:BHF, GOC:mah]
positive regulation of fibronectin-dependent thymocyte migration	biological process	Any process that activates or increases the frequency, rate or extent of fibronectin-dependent thymocyte migration. [GOC:BHF, GOC:mah]
positive regulation of eosinophil migration	biological process	Any process that activates or increases the frequency, rate or extent of eosinophil migration. [GOC:mah]
positive regulation of cellular extravasation	biological process	Any process that activates or increases the frequency, rate, or extent of cellular extravasation. [GOC:add]
proteolysis	biological process	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]