| Condition | Indicated | Relationship Strength | Studies | Trials |
|---|
Congenital Zika Syndrome
[description not available] | 0 | 2.25 | 1 | 0 |
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. | 0 | 2.88 | 3 | 0 |
Zika Virus Infection
A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME. | 0 | 2.25 | 1 | 0 |
Dysmyelopoietic Syndromes
[description not available] | 0 | 6.43 | 4 | 1 |
Acute Myelogenous Leukemia
[description not available] | 0 | 8.03 | 8 | 2 |
Myelodysplastic Syndromes
Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA. | 1 | 8.43 | 4 | 1 |
Leukemia, Myeloid, Acute
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES. | 0 | 8.03 | 8 | 2 |
Esophageal Squamous Cell Carcinoma
A carcinoma that originates usually from cells on the surface of the middle and lower third of the ESOPHAGUS. Tumor cells exhibit typical squamous morphology and form large polypoid lesions. Mutations in RNF6, LZTS1, TGFBR2, DEC1, and WWOX1 genes are associated with this cancer. | 0 | 2.31 | 1 | 0 |
Cancer of Esophagus
[description not available] | 0 | 2.58 | 2 | 0 |
Esophageal Neoplasms
Tumors or cancer of the ESOPHAGUS. | 1 | 4.58 | 2 | 0 |
Benign Neoplasms
[description not available] | 0 | 8.07 | 9 | 1 |
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. | 0 | 8.07 | 9 | 1 |
Cancer of Pancreas
[description not available] | 0 | 3.51 | 5 | 0 |
Carcinoma, Ductal, Pancreatic
[description not available] | 0 | 2.82 | 2 | 0 |
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA). | 0 | 3.51 | 5 | 0 |
Carcinoma, Pancreatic Ductal
Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS. | 0 | 2.82 | 2 | 0 |
Adenocarcinoma, Basal Cell
[description not available] | 0 | 2.79 | 3 | 0 |
Adenocarcinoma
A malignant epithelial tumor with a glandular organization. | 0 | 7.79 | 3 | 0 |
Epithelial Ovarian Cancer
[description not available] | 0 | 2.61 | 2 | 0 |
Cancer of Ovary
[description not available] | 0 | 3.43 | 6 | 0 |
Carcinoma, Ovarian Epithelial
A malignant neoplasm that originates in cells on the surface EPITHELIUM of the ovary and is the most common form of ovarian cancer. There are five histologic subtypes: papillary serous, endometrioid, mucinous, clear cell, and transitional cell. Mutations in BRCA1, OPCML, PRKN, PIK3CA, AKT1, CTNNB1, RRAS2, and CDH1 genes are associated with this cancer. | 0 | 2.61 | 2 | 0 |
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. | 1 | 5.43 | 6 | 0 |
Diffuse Large B-Cell Lymphoma
[description not available] | 0 | 7.41 | 1 | 0 |
Lymphoma, Large B-Cell, Diffuse
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation. | 0 | 2.41 | 1 | 0 |
Innate Inflammatory Response
[description not available] | 0 | 2.41 | 1 | 0 |
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. | 0 | 2.41 | 1 | 0 |
Rheumatoid Arthritis
[description not available] | 0 | 2.6 | 1 | 0 |
Arthritis, Rheumatoid
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated. | 0 | 2.6 | 1 | 0 |
Thrombopenia
[description not available] | 0 | 3.99 | 1 | 1 |
Thrombocytopenia
A subnormal level of BLOOD PLATELETS. | 0 | 3.99 | 1 | 1 |
B-Cell Chronic Lymphocytic Leukemia
[description not available] | 0 | 2.25 | 1 | 0 |
Leukemia, Lymphocytic, Chronic, B-Cell
A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease. | 0 | 2.25 | 1 | 0 |
Brain Stem Neoplasms, Primary
[description not available] | 0 | 2.25 | 1 | 0 |
Glial Cell Tumors
[description not available] | 0 | 2.25 | 1 | 0 |
Glioma
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21) | 0 | 2.25 | 1 | 0 |
Brain Stem Neoplasms
Benign and malignant intra-axial tumors of the MESENCEPHALON; PONS; or MEDULLA OBLONGATA of the BRAIN STEM. Primary and metastatic neoplasms may occur in this location. Clinical features include ATAXIA, cranial neuropathies (see CRANIAL NERVE DISEASES), NAUSEA, hemiparesis (see HEMIPLEGIA), and quadriparesis. Primary brain stem neoplasms are more frequent in children. Histologic subtypes include GLIOMA; HEMANGIOBLASTOMA; GANGLIOGLIOMA; and EPENDYMOMA. | 0 | 2.25 | 1 | 0 |
Anhidrotic Ectodermal Dysplasia
[description not available] | 0 | 2.81 | 3 | 0 |
ER-Negative PR-Negative HER2-Negative Breast Cancer
[description not available] | 0 | 3.11 | 4 | 0 |
Triple Negative Breast Neoplasms
Breast neoplasms that do not express ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and do not overexpress the NEU RECEPTOR/HER-2 PROTO-ONCOGENE PROTEIN. | 0 | 3.11 | 4 | 0 |
Benign Neoplasms, Brain
[description not available] | 0 | 2.31 | 1 | 0 |
Astrocytoma, Grade IV
[description not available] | 0 | 2.59 | 2 | 0 |
Brain Neoplasms
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain. | 0 | 2.31 | 1 | 0 |
Glioblastoma
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures. | 0 | 7.59 | 2 | 0 |
Acute Lymphoid Leukemia
[description not available] | 0 | 2.31 | 1 | 0 |
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias. | 0 | 2.31 | 1 | 0 |
Carcinoma, Epidermoid
[description not available] | 0 | 2.51 | 2 | 0 |
Cancer of Head
[description not available] | 0 | 2.51 | 2 | 0 |
Carcinoma, Squamous Cell
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed) | 0 | 2.51 | 2 | 0 |
Head and Neck Neoplasms
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651) | 0 | 2.51 | 2 | 0 |
Cancer of the Thyroid
[description not available] | 0 | 2.17 | 1 | 0 |
Thyroid Neoplasms
Tumors or cancer of the THYROID GLAND. | 0 | 2.17 | 1 | 0 |
Kahler Disease
[description not available] | 0 | 2.79 | 3 | 0 |
Experimental Neoplasms
[description not available] | 0 | 2.5 | 2 | 0 |
Multiple Myeloma
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY. | 0 | 7.79 | 3 | 0 |
Bone Cancer
[description not available] | 0 | 2.45 | 2 | 0 |
Ewing Sarcoma
[description not available] | 0 | 7.08 | 1 | 0 |
Bone Neoplasms
Tumors or cancer located in bone tissue or specific BONES. | 0 | 2.45 | 2 | 0 |
Sarcoma, Ewing
A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. The tumor occurs usually before the age of 20, about twice as frequently in males as in females. | 0 | 2.08 | 1 | 0 |
Familial Waldenstrom's Macroglobulinaemia
[description not available] | 0 | 2.11 | 1 | 0 |
Waldenstrom Macroglobulinemia
A lymphoproliferative disorder characterized by pleomorphic B-LYMPHOCYTES including PLASMA CELLS, with increased levels of monoclonal serum IMMUNOGLOBULIN M. There is lymphoplasmacytic cells infiltration into bone marrow and often other tissues, also known as lymphoplasmacytic lymphoma. Clinical features include ANEMIA; HEMORRHAGES; and hyperviscosity. | 0 | 2.11 | 1 | 0 |
Colorectal Cancer
[description not available] | 0 | 7.52 | 2 | 0 |
Colorectal Neoplasms
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI. | 0 | 2.52 | 2 | 0 |
Sarcoma, Epithelioid
[description not available] | 0 | 2.11 | 1 | 0 |
Sarcoma
A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant. | 0 | 2.11 | 1 | 0 |
Genetic Predisposition
[description not available] | 0 | 2.13 | 1 | 0 |
Malignant Melanoma
[description not available] | 0 | 7.77 | 3 | 0 |
Cancer of Skin
[description not available] | 0 | 2.49 | 2 | 0 |
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445) | 1 | 4.77 | 3 | 0 |
Skin Neoplasms
Tumors or cancer of the SKIN. | 0 | 2.49 | 2 | 0 |
Metaplasia
A condition in which there is a change of one adult cell type to another similar adult cell type. | 0 | 7.13 | 1 | 0 |
Pterygium
An abnormal triangular fold of membrane in the interpalpebral fissure, extending from the conjunctiva to the cornea, being immovably united to the cornea at its apex, firmly attached to the sclera throughout its middle portion, and merged with the conjunctiva at its base. (Dorland, 27th ed) | 0 | 2.13 | 1 | 0 |
Carcinoma, Non-Small Cell Lung
[description not available] | 0 | 2.46 | 2 | 0 |
Carcinoma, Non-Small-Cell Lung
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy. | 0 | 2.46 | 2 | 0 |
Epithelial Neoplasms
[description not available] | 0 | 2.13 | 1 | 0 |
Cystadenocarcinoma, Serous
A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185) | 0 | 2.13 | 1 | 0 |
Metastase
[description not available] | 0 | 2.13 | 1 | 0 |
Neoplasm Metastasis
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site. | 0 | 2.13 | 1 | 0 |
Hematologic Malignancies
[description not available] | 0 | 11.01 | 18 | 9 |
Hematologic Neoplasms
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES. | 0 | 11.01 | 18 | 9 |
Cell Transformation, Viral
An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus. | 0 | 2.05 | 1 | 0 |
Disease Exacerbation
[description not available] | 0 | 2.06 | 1 | 0 |
Carcinoma, Small Cell Lung
[description not available] | 0 | 2.06 | 1 | 0 |
Cancer of Lung
[description not available] | 0 | 2.44 | 2 | 0 |
Lung Neoplasms
Tumors or cancer of the LUNG. | 0 | 2.44 | 2 | 0 |
Small Cell Lung Carcinoma
A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA). | 0 | 2.06 | 1 | 0 |
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed) | 0 | 7.37 | 10 | 0 |
Cancer of Prostate
[description not available] | 0 | 6.36 | 9 | 0 |
Prostatic Neoplasms
Tumors or cancer of the PROSTATE. | 0 | 6.36 | 9 | 0 |
Harelip
[description not available] | 0 | 2.49 | 2 | 0 |
Cleft Palate, Isolated
[description not available] | 0 | 2.49 | 2 | 0 |
Cleft Lip
Congenital defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences. It is thought to be caused by faulty migration of the mesoderm in the head region. | 0 | 2.49 | 2 | 0 |
Cleft Palate
Congenital fissure of the soft and/or hard palate, due to faulty fusion. | 0 | 2.49 | 2 | 0 |
Osteogenic Sarcoma
[description not available] | 0 | 2.02 | 1 | 0 |
Osteosarcoma
A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed) | 0 | 2.02 | 1 | 0 |