Page last updated: 2024-10-24

UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity

Definition

Target type: molecularfunction

Catalysis of the removal of an acetyl group from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine. [PMID:10026271]

UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase catalyzes the removal of the acetyl group from the N-acetylglucosamine moiety of UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine. This reaction is a key step in the biosynthesis of lipid A, a major component of the outer membrane of Gram-negative bacteria. Lipid A is a potent immunostimulant, and its biosynthesis is tightly regulated. UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase is a highly specific enzyme that only deacetylates UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine. The enzyme is essential for bacterial survival, and its inhibition is a potential target for the development of new antibiotics.'
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Proteins (1)

ProteinDefinitionTaxonomy
UDP-3-O-acyl-N-acetylglucosamine deacetylaseA UDP-3-O-acyl-N-acetylglucosamine deacetylase that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A725]Escherichia coli K-12

Compounds (4)

CompoundDefinitionClassesRoles
tu-514
bb-78485BB-78485: structure in first source
l 161240
chir 090CHIR 090: structure in first source

CHIR-090 : An L-threonine derivative obtained by formal condensation of the carboxy group of 4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzoic acid with the amino group of N-hydroxy-L-threoninamide.
acetylenic compound;
benzamides;
hydroxamic acid;
L-threonine derivative;
morpholines
antimicrobial agent;
EC 3.5.1.108 (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor;
lipopolysaccharide biosynthesis inhibitor