Target type: molecularfunction
Catalysis of the removal of an acetyl group from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine. [PMID:10026271]
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase catalyzes the removal of the acetyl group from the N-acetylglucosamine moiety of UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine. This reaction is a key step in the biosynthesis of lipid A, a major component of the outer membrane of Gram-negative bacteria. Lipid A is a potent immunostimulant, and its biosynthesis is tightly regulated. UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase is a highly specific enzyme that only deacetylates UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine. The enzyme is essential for bacterial survival, and its inhibition is a potential target for the development of new antibiotics.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| UDP-3-O-acyl-N-acetylglucosamine deacetylase | A UDP-3-O-acyl-N-acetylglucosamine deacetylase that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A725] | Escherichia coli K-12 |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| tu-514 | |||
| bb-78485 | BB-78485: structure in first source | ||
| l 161240 | |||
| chir 090 | CHIR 090: structure in first source CHIR-090 : An L-threonine derivative obtained by formal condensation of the carboxy group of 4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzoic acid with the amino group of N-hydroxy-L-threoninamide. | acetylenic compound; benzamides; hydroxamic acid; L-threonine derivative; morpholines | antimicrobial agent; EC 3.5.1.108 (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor; lipopolysaccharide biosynthesis inhibitor |