Target type: molecularfunction
Catalysis of the reaction: UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetylglucosamine(2-) + H2O = UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(1-) + acetate. [EC:3.5.1.108, GOC:pz]
UDP-3-O-acyl-N-acetylglucosamine deacetylase activity catalyzes the hydrolysis of the N-acetyl group from UDP-3-O-acyl-N-acetylglucosamine, producing UDP-3-O-acyl-glucosamine and acetate. This reaction is a key step in the biosynthesis of bacterial cell wall peptidoglycans, a major component of the bacterial cell envelope. The enzyme is specific for the 3-O-acyl moiety of the substrate and requires a divalent metal ion, such as Mg2+, for activity. The deacetylation reaction is essential for the formation of the peptidoglycan precursor, UDP-N-acetylmuramic acid, which is then used in the synthesis of the peptidoglycan polymer. The enzyme is also involved in the biosynthesis of other bacterial cell wall polysaccharides. UDP-3-O-acyl-N-acetylglucosamine deacetylase activity is a potential target for the development of new antibacterial drugs.'
"
| Protein | Definition | Taxonomy |
|---|---|---|
| UDP-3-O-acyl-N-acetylglucosamine deacetylase | A UDP-3-O-acyl-N-acetylglucosamine deacetylase that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A725] | Escherichia coli K-12 |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| tu-514 | |||
| bb-78485 | BB-78485: structure in first source | ||
| l 161240 | |||
| chir 090 | CHIR 090: structure in first source CHIR-090 : An L-threonine derivative obtained by formal condensation of the carboxy group of 4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzoic acid with the amino group of N-hydroxy-L-threoninamide. | acetylenic compound; benzamides; hydroxamic acid; L-threonine derivative; morpholines | antimicrobial agent; EC 3.5.1.108 (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor; lipopolysaccharide biosynthesis inhibitor |