Page last updated: 2024-10-24

UDP-3-O-acyl-N-acetylglucosamine deacetylase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetylglucosamine(2-) + H2O = UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(1-) + acetate. [EC:3.5.1.108, GOC:pz]

UDP-3-O-acyl-N-acetylglucosamine deacetylase activity catalyzes the hydrolysis of the N-acetyl group from UDP-3-O-acyl-N-acetylglucosamine, producing UDP-3-O-acyl-glucosamine and acetate. This reaction is a key step in the biosynthesis of bacterial cell wall peptidoglycans, a major component of the bacterial cell envelope. The enzyme is specific for the 3-O-acyl moiety of the substrate and requires a divalent metal ion, such as Mg2+, for activity. The deacetylation reaction is essential for the formation of the peptidoglycan precursor, UDP-N-acetylmuramic acid, which is then used in the synthesis of the peptidoglycan polymer. The enzyme is also involved in the biosynthesis of other bacterial cell wall polysaccharides. UDP-3-O-acyl-N-acetylglucosamine deacetylase activity is a potential target for the development of new antibacterial drugs.'
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Proteins (1)

ProteinDefinitionTaxonomy
UDP-3-O-acyl-N-acetylglucosamine deacetylaseA UDP-3-O-acyl-N-acetylglucosamine deacetylase that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0A725]Escherichia coli K-12

Compounds (4)

CompoundDefinitionClassesRoles
tu-514
bb-78485BB-78485: structure in first source
l 161240
chir 090CHIR 090: structure in first source

CHIR-090 : An L-threonine derivative obtained by formal condensation of the carboxy group of 4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzoic acid with the amino group of N-hydroxy-L-threoninamide.
acetylenic compound;
benzamides;
hydroxamic acid;
L-threonine derivative;
morpholines
antimicrobial agent;
EC 3.5.1.108 (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor;
lipopolysaccharide biosynthesis inhibitor