Proteins > UDP-3-O-acyl-N-acetylglucosamine deacetylase
Page last updated: 2024-08-07 18:36:05
UDP-3-O-acyl-N-acetylglucosamine deacetylase
[no definition available]
Synonyms
UDP-3-O-acyl-GlcNAc deacetylase;
EC 3.5.1.108;
UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase
Research
Bioassay Publications (5)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
Compounds (1)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| chir 090 | Pseudomonas aeruginosa PAO1 | IC50 | 0.0788 | 4 | 4 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| chir 090 | Pseudomonas aeruginosa PAO1 | Kd | 0.0005 | 1 | 1 |
N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay.Bioorganic & medicinal chemistry, , 12-15, Volume: 28, Issue:24, 2020
Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline.Journal of medicinal chemistry, , 10-25, Volume: 61, Issue:20, 2018
Drug discovery strategies to outer membrane targets in Gram-negative pathogens.Bioorganic & medicinal chemistry, , 12-15, Volume: 24, Issue:24, 2016
Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors.ACS medicinal chemistry letters, , Nov-13, Volume: 5, Issue:11, 2014
Potent inhibitors of LpxC for the treatment of Gram-negative infections.Journal of medicinal chemistry, , Jan-26, Volume: 55, Issue:2, 2012