Compounds > dactylarin
Page last updated: 2024-12-08

dactylarin

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Description

dactylarin: isolated from Dactylaria lutea (Deuteromycetes); structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID161389
CHEMBL ID2011669
SCHEMBL ID23522406
MeSH IDM0048383

Synonyms (12)

Synonym
dactylarin
(2r,3s)-2,3,8-trihydroxy-6-methoxy-3-methyl-2,4-dihydro-1h-anthracene-9,10-dione
9,10-anthracenedione, 1,2,3,4-tetrahydro-2,3,5-trihydroxy-7-methoxy-2-methyl-, (2s,3r)-
9,10-anthracenedione, 1,2,3,4-tetrahydro-2,3,5-trihydroxy-7-methoxy-2-methyl-, (2s-cis)-
3,7-dihydroxy-2',5-dimethoxy-6'-methylspiro(benzofuran-2(3h),1'-(2,5)cyclohexadien)-4'-one
22350-90-9
altersolanol b
CHEMBL2011669
DTXSID70176887
SCHEMBL23522406
3,7-dihydroxy-3',5-dimethoxy-5'-methylspiro[3h-1-benzofuran-2,4'-cyclohexa-2,5-diene]-1'-one
AKOS040745714
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID1188350Antimicrobial activity against Micrococcus tetragenus ATCC 13623 by broth dilution assay2014Journal of natural products, Sep-26, Volume: 77, Issue:9
Bioactive anthraquinone derivatives from the mangrove-derived fungus Stemphylium sp. 33231.
AID654534Cytotoxicity against human PC3 cells after 6 days by MTT assay2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Bioactive hydroanthraquinones and anthraquinone dimers from a soft coral-derived Alternaria sp. fungus.
AID1188347Cytotoxic activity against mouse B16F10 cells by MTT assay2014Journal of natural products, Sep-26, Volume: 77, Issue:9
Bioactive anthraquinone derivatives from the mangrove-derived fungus Stemphylium sp. 33231.
AID1188348Cytotoxic activity against human A549 cells by MTT assay2014Journal of natural products, Sep-26, Volume: 77, Issue:9
Bioactive anthraquinone derivatives from the mangrove-derived fungus Stemphylium sp. 33231.
AID1072978Antimicrobial activity against Pseudomonas aeruginosa2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Isolation, structure elucidation, and biological activity of altersolanol P using Staphylococcus aureus fitness test based genome-wide screening.
AID1188354Antimicrobial activity against Staphylococcus aureus ATCC 6538 by broth dilution assay2014Journal of natural products, Sep-26, Volume: 77, Issue:9
Bioactive anthraquinone derivatives from the mangrove-derived fungus Stemphylium sp. 33231.
AID1188353Antimicrobial activity against Bacillus cereus ATCC 14579 by broth dilution assay2014Journal of natural products, Sep-26, Volume: 77, Issue:9
Bioactive anthraquinone derivatives from the mangrove-derived fungus Stemphylium sp. 33231.
AID1188356Antimicrobial activity against Bacillus subtilis ATCC 6633 by broth dilution assay2014Journal of natural products, Sep-26, Volume: 77, Issue:9
Bioactive anthraquinone derivatives from the mangrove-derived fungus Stemphylium sp. 33231.
AID1188355Antimicrobial activity against Kocuria rhizophila ATCC 9341 by broth dilution assay2014Journal of natural products, Sep-26, Volume: 77, Issue:9
Bioactive anthraquinone derivatives from the mangrove-derived fungus Stemphylium sp. 33231.
AID1072979Antimicrobial activity against Staphylococcus aureus2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Isolation, structure elucidation, and biological activity of altersolanol P using Staphylococcus aureus fitness test based genome-wide screening.
AID654536Cytotoxicity against human Hep3B cells after 6 days by MTT assay2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Bioactive hydroanthraquinones and anthraquinone dimers from a soft coral-derived Alternaria sp. fungus.
AID654535Cytotoxicity against human HepG2 cells after 6 days by MTT assay2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Bioactive hydroanthraquinones and anthraquinone dimers from a soft coral-derived Alternaria sp. fungus.
AID654532Cytotoxicity against human HCT116 cells after 6 days by MTT assay2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Bioactive hydroanthraquinones and anthraquinone dimers from a soft coral-derived Alternaria sp. fungus.
AID1188352Antimicrobial activity against Staphylococcus albus ATCC 8799 by broth dilution assay2014Journal of natural products, Sep-26, Volume: 77, Issue:9
Bioactive anthraquinone derivatives from the mangrove-derived fungus Stemphylium sp. 33231.
AID1188351Antimicrobial activity against Escherichia coli ATCC 25922 by broth dilution assay2014Journal of natural products, Sep-26, Volume: 77, Issue:9
Bioactive anthraquinone derivatives from the mangrove-derived fungus Stemphylium sp. 33231.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (50.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.38

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.38 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.38)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
adenine
[no description available]		1.95106-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
ciprofloxacin
Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.		2.4920aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion		antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic
penicillin g
Penicillin G: A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.. benzylpenicillin : A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group.		2.110penicillin allergen;
penicillin		antibacterial drug;
drug allergen;
epitope
epirubicin
Epirubicin: An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.		2.0710aminoglycoside;
anthracycline antibiotic;
anthracycline;
deoxy hexoside;
monosaccharide derivative;
p-quinones;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone		antimicrobial agent;
antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
altersolanol a
altersolanol A: isolated from fermentation product of fungus Alternaria porri(Ellis) Ciferri;RN given refers to (1R-(1alpha,2beta,3beta,4alpha))-isomer; structure given in first source		2.520pentahydroxyanthraquinone
macrosporin
macrosporin: isolated from fermentation product of fungus Alternaria porri (Ellis) Ciferri; structure given in first source		2.4920
dactylariol
dactylariol: structure		2.7830
benzofurans
Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.		2.6530
inosine
[no description available]		1.9510inosines;
purines D-ribonucleoside		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Carcinoma, Ehrlich Tumor
A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.		02.6530