agn-191659 and Hemorrhage

We studied the effect of radioprotector indralin (B-190) alone or in combination with monizol on BP and HR in rabbits, reduction of blood supply and spleen weight in rats and (CBA×C57Bl/6)F1 hybrids mice, and on blood loss from a wound on tip of the tail in mice. Being an α1-adrenomimetic, indralin caused hypertensive reaction with the development of bradycardia, reduced blood supply and spleen weight, and sharply reduced blood loss from the wound. Monizol as nitrate reduced BP without affecting HR and reduced blood loss from the wound. Monizol administered prior to indralin eliminated radioprotector-induced hypertensive reaction, reduced bradycardia by more than 2 times, and attenuated the effect of indralin on spleen weight and blood loss from the wound by 1.6-1.8 times. Monizol administered after indralin had no effect on shifts in peripheral blood supply caused by the radioprotector.

Topics: Animals; Antihypertensive Agents; Blood Pressure; Crosses, Genetic; Drug Administration Schedule; Drug Combinations; Drug Synergism; Female; Heart Rate; Hemorrhage; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Nitrates; Organ Size; Phenols; Rabbits; Radiation-Protective Agents; Rats; Spleen; Surgical Wound