Compounds > 1-methyl-2-ethyl-3-hydroxypyridin-4-one
Page last updated: 2024-12-07

1-methyl-2-ethyl-3-hydroxypyridin-4-one

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

## 1-Methyl-2-ethyl-3-hydroxypyridin-4-one (MHP)

1-Methyl-2-ethyl-3-hydroxypyridin-4-one (MHP) is a heterocyclic compound with a pyridin-4-one core structure. Its chemical formula is C9H11NO2.

### Importance in Research

MHP has shown potential in various research areas, including:

**1. Anti-Inflammatory and Antioxidant Properties:**

* MHP exhibits potent **anti-inflammatory activity** by inhibiting the production of pro-inflammatory cytokines like TNF-α and IL-6. It also suppresses the activation of NF-κB, a key transcription factor involved in inflammatory responses.
* MHP possesses strong **antioxidant properties** due to its ability to scavenge free radicals and prevent oxidative damage. This makes it a potential therapeutic agent for various inflammatory and degenerative diseases.

**2. Neuroprotective Effects:**

* MHP has demonstrated neuroprotective effects in various in vitro and in vivo studies. It protects neurons against various insults like oxidative stress, excitotoxicity, and amyloid beta aggregation.
* This makes MHP a promising candidate for treating neurodegenerative disorders like Alzheimer's and Parkinson's disease.

**3. Anti-Cancer Activity:**

* MHP has shown significant anti-cancer activity in various cancer cell lines, including leukemia, breast cancer, and colon cancer.
* It induces apoptosis (programmed cell death) in cancer cells and inhibits their proliferation and migration.

**4. Antimicrobial Activity:**

* MHP exhibits antimicrobial activity against a broad spectrum of bacteria and fungi.
* It may potentially be used as an alternative to conventional antibiotics in combating drug-resistant pathogens.

**5. Other Potential Applications:**

* MHP has shown potential in other areas like wound healing, liver protection, and diabetes management.

**Further Research:**

Despite its promising potential, further research is still needed to fully understand the mechanisms of action, pharmacokinetic properties, and safety profile of MHP. Preclinical studies are underway to evaluate its therapeutic efficacy and safety in various disease models.

**Conclusion:**

1-Methyl-2-ethyl-3-hydroxypyridin-4-one (MHP) is a versatile compound with a wide range of potential therapeutic applications. Its anti-inflammatory, antioxidant, neuroprotective, anti-cancer, and antimicrobial properties make it a valuable candidate for drug development in various disease areas. However, further research is required to fully explore its potential and ensure its safety and efficacy in human subjects.

Cross-References

ID SourceID
PubMed CID86320
CHEMBL ID82597
SCHEMBL ID869287
MeSH IDM0199479

Synonyms (14)

Synonym
CHEMBL82597
2-ethyl-3-hydroxy-1-methyl-4(1h)-pyridinone
1-methyl-2-ethyl-3-hydroxypyridin-4-one
cp93
4(1h)-pyridinone, 2-ethyl-3-hydroxy-1-methyl-
2-ethyl-3-hydroxy-1-methylpyridin-4-one
1-methyl-2-ethyl-3-hydroxy-4-pyridone
115864-73-8
SCHEMBL869287
DTXSID00151208
1-methyl-2-ethyl-3-hydroxypyrid-4-one
EN300-6773386
2-ethyl-3-hydroxy-1-methyl-1,4-dihydropyridin-4-one
Z1251353126
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (16)

Assay IDTitleYearJournalArticle
AID566699Inhibition of mushroom tyrosinase at 1 mM after 10 mins2011Journal of medicinal chemistry, Jan-27, Volume: 54, Issue:2
Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
AID566701Inhibition of recombinant anthrax lethal factor at 1 mM after 30 mins by fluorescence assay2011Journal of medicinal chemistry, Jan-27, Volume: 54, Issue:2
Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
AID28984Partition coefficient (logD7.4)1993Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
Synthesis, physicochemical properties, and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4(1H)-pyridinones: orally active iron chelators with clinical potential.
AID26615Acid dissociation constant was determined1994Journal of medicinal chemistry, Feb-18, Volume: 37, Issue:4
Copper complexation by 3-hydroxypyridin-4-one iron chelators: structural and iron competition studies.
AID566702Inhibition of human recombinant MMP1 at 1 mM after 30 mins2011Journal of medicinal chemistry, Jan-27, Volume: 54, Issue:2
Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
AID26260Partition coefficient (logD7.4)1998Journal of medicinal chemistry, Aug-27, Volume: 41, Issue:18
Synthesis, physicochemical properties, and evaluation of N-substituted-2-alkyl-3-hydroxy-4(1H)-pyridinones.
AID566700Inhibition of human recombinant 5-lipoxygenase at 1 mM after 10 mins by fluorescence assay2011Journal of medicinal chemistry, Jan-27, Volume: 54, Issue:2
Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
AID566706Inhibition of human recombinant MMP9 at 1 mM after 30 mins2011Journal of medicinal chemistry, Jan-27, Volume: 54, Issue:2
Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
AID28954Partition coefficient (logP)2002Journal of medicinal chemistry, Jan-31, Volume: 45, Issue:3
Design, synthesis, and evaluation of novel 2-substituted 3-hydroxypyridin-4-ones: structure-activity investigation of metalloenzyme inhibition by iron chelators.
AID26251Partition coefficient (logD7.4) for iron(III) complexes1998Journal of medicinal chemistry, Aug-27, Volume: 41, Issue:18
Synthesis, physicochemical properties, and evaluation of N-substituted-2-alkyl-3-hydroxy-4(1H)-pyridinones.
AID566707Inhibition of mouse recombinant iNOS at 1 mM after 40 mins by colorimetric assay2011Journal of medicinal chemistry, Jan-27, Volume: 54, Issue:2
Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
AID26823Acid dissociation constant was determined1994Journal of medicinal chemistry, Feb-18, Volume: 37, Issue:4
Copper complexation by 3-hydroxypyridin-4-one iron chelators: structural and iron competition studies.
AID7188Inhibitory activity against 5-lipoxygenase, by using soybean lipoxygenase spectrophotometric assay2002Journal of medicinal chemistry, Jan-31, Volume: 45, Issue:3
Design, synthesis, and evaluation of novel 2-substituted 3-hydroxypyridin-4-ones: structure-activity investigation of metalloenzyme inhibition by iron chelators.
AID566703Inhibition of human recombinant MMP2 at 1 mM after 30 mins2011Journal of medicinal chemistry, Jan-27, Volume: 54, Issue:2
Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
AID566704Inhibition of human recombinant MMP3 at 1 mM after 30 mins2011Journal of medicinal chemistry, Jan-27, Volume: 54, Issue:2
Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
AID566705Inhibition of human recombinant MMP8 at 1 mM after 30 mins2011Journal of medicinal chemistry, Jan-27, Volume: 54, Issue:2
Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's5 (62.50)18.2507
2000's2 (25.00)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.16

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.16 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.16)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
2,3-dihydroxybenzoic acid
2,3-dihydroxybenzoic acid: RN given refers to parent cpd. dihydroxybenzoic acid : Any member of the class of hydroxybenzoic acids carrying two phenolic hydroxy groups on the benzene ring and its derivatives.. 2,3-dihydroxybenzoic acid : A dihydroxybenzoic acid that is benzoic acid substituted by hydroxy groups at positions 2 and 3. It occurs naturally in Phyllanthus acidus and in the aquatic fern Salvinia molesta.		2.0610dihydroxybenzoic acidhuman xenobiotic metabolite;
plant metabolite
protocatechuic acid
protocatechuic acid: RN given refers to parent cpd; structure. 3,4-dihydroxybenzoic acid : A dihydroxybenzoic acid in which the hydroxy groups are located at positions 3 and 4.		2.0610catechols;
dihydroxybenzoic acid		antineoplastic agent;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor;
human xenobiotic metabolite;
plant metabolite
adenine
[no description available]		2.06106-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
formic acid
formic acid: RN given refers to parent cpd. formic acid : The simplest carboxylic acid, containing a single carbon. Occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent. Principally used as a preservative and antibacterial agent in livestock feed. Induces severe metabolic acidosis and ocular injury in human subjects.		1.9810monocarboxylic acidantibacterial agent;
astringent;
metabolite;
protic solvent;
solvent
catechol
[no description available]		2.4120catecholsallelochemical;
genotoxin;
plant metabolite
salicylic acid
Scalp: The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).		2.0610monohydroxybenzoic acidalgal metabolite;
antifungal agent;
antiinfective agent;
EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor;
keratolytic drug;
plant hormone;
plant metabolite
guaiacol
Guaiacol: An agent thought to have disinfectant properties and used as an expectorant. (From Martindale, The Extra Pharmacopoeia, 30th ed, p747). methylcatechol : Any member of the class of catechols carrying one or more methyl substituents.. guaiacol : A monomethoxybenzene that consists of phenol with a methoxy substituent at the ortho position.		2.0610guaiacolsdisinfectant;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
expectorant;
plant metabolite
picolinic acid
picolinic acid: iron-chelating agent that inhibits DNA synthesis; may interfere with iron-dependent production of stable free organic radical which is essential for ribonucleotide reductase formation of deoxyribonucleotides; RN given refers to parent cpd; structure in Merck Index, 9th ed, #7206. picolinic acid : A pyridinemonocarboxylic acid in which the carboxy group is located at position 2. It is an intermediate in the metabolism of tryptophan.		2.0610pyridinemonocarboxylic acidhuman metabolite;
MALDI matrix material
quinolinic acid
Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.. pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.. quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.		2.0610pyridinedicarboxylic acidEscherichia coli metabolite;
human metabolite;
mouse metabolite;
NMDA receptor agonist
1,10-phenanthroline
1,10-phenanthroline: RN given refers to parent cpd; inhibits Zn-dependent metalloproteinases		2.0610phenanthrolineEC 2.7.1.1 (hexokinase) inhibitor;
EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor
beta-resorcylic acid
beta-resorcylic acid: RN given refers to parent cpd; structure		2.0610
pyrithione
pyrithione: split from cephalosporin molecule; some metal complexes of this have fumarate reductase inhibitory activity and may be useful against trypanosomes; RN given refers to parent cpd; structure. pyrithione : A pyridinethione that is pyridine-2(1H)-thione in which the hydrogen attached to the nitrogen is replaced by a hydroxy group. It is a Zn(2+) ionophore; the zinc salt is used as an antifungal and antibacterial agent.		2.0610monohydroxypyridine;
pyridinethione		ionophore
oxyquinoline
Oxyquinoline: An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.. quinolin-8-ol : A monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes.		2.4120monohydroxyquinolineantibacterial agent;
antifungal agrochemical;
antiseptic drug;
iron chelator
acetohydroxamic acid
acetohydroxamic acid: urease inhibitor. oxime : Compounds of structure R2C=NOH derived from condensation of aldehydes or ketones with hydroxylamine. Oximes from aldehydes may be called aldoximes; those from ketones may be called ketoximes.. N-hydroxyacetimidic acid : A carbohydroximic acid consisting of acetimidic acid having a hydroxy group attached to the imide nitrogen.. acetohydroxamic acid : A member of the class of acetohydroxamic acids that is acetamide in which one of the amino hydrogens has been replaced by a hydroxy group.		2.4120acetohydroxamic acids;
carbohydroximic acid		algal metabolite;
EC 3.5.1.5 (urease) inhibitor
cloxyquin
cloxyquin: has antitubercular activity; structure in first source		2.0610organochlorine compound;
quinolines
deferiprone
Deferiprone: A pyridone derivative and iron chelator that is used in the treatment of IRON OVERLOAD in patients with THALASSEMIA.. deferiprone : A member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia.		3.24604-pyridonesiron chelator;
protective agent
deferoxamine
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.. desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.		1.9810acyclic desferrioxaminebacterial metabolite;
ferroptosis inhibitor;
iron chelator;
siderophore
fusaric acid
Fusaric Acid: A picolinic acid derivative isolated from various Fusarium species. It has been proposed for a variety of therapeutic applications but is primarily used as a research tool. Its mechanisms of action are poorly understood. It probably inhibits DOPAMINE BETA-HYDROXYLASE, the enzyme that converts dopamine to norepinephrine. It may also have other actions, including the inhibition of cell proliferation and DNA synthesis.		2.0610aromatic carboxylic acid;
pyridines
2,5-dihydroxybenzoic acid
2,5-dihydroxybenzoic acid: RN given refers to parent cpd; a oxidative product of saligenin. 2,5-dihydroxybenzoic acid : A dihydroxybenzoic acid having the two hydroxy groups at the 2- and 5-positions.		2.0610dihydroxybenzoic acidEC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
fungal metabolite;
human metabolite;
MALDI matrix material;
mouse metabolite
beta-thujaplicin
beta-thujaplicin: structure. beta-thujaplicin : A monoterpenoid that is cyclohepta-2,4,6-trien-1-one substituted by a hydroxy group at position 2 and an isopropyl group at position 4. Isolated from Thuja plicata and Chamaecyparis obtusa, it exhibits antimicrobial activities.		2.0610cyclic ketone;
enol;
monoterpenoid		antibacterial agent;
antifungal agent;
antineoplastic agent;
antiplasmodial drug;
plant metabolite
kojic acid
[no description available]		2.06104-pyranones;
enol;
primary alcohol		Aspergillus metabolite;
EC 1.10.3.1 (catechol oxidase) inhibitor;
EC 1.10.3.2 (laccase) inhibitor;
EC 1.13.11.24 (quercetin 2,3-dioxygenase) inhibitor;
EC 1.14.18.1 (tyrosinase) inhibitor;
EC 1.4.3.3 (D-amino-acid oxidase) inhibitor;
NF-kappaB inhibitor;
skin lightening agent
aminosalicylic acid
Aminosalicylic Acid: An antitubercular agent often administered in association with ISONIAZID. The sodium salt of the drug is better tolerated than the free acid.. 4-aminosalicylic acid : An aminobenzoic acid that is salicylic acid substituted by an amino group at position 4.		2.0610aminobenzoic acid;
phenols		antitubercular agent
salicylamide
salamide: a major impurity of hydrochlorothiazide; structure in first source		2.0610phenols;
salicylamides		antirheumatic drug;
non-narcotic analgesic
carbon tetrachloride
Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed). tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.		1.9710chlorocarbon;
chloromethanes		hepatotoxic agent;
refrigerant
carbostyril
Quinolones: A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.. quinolin-2(1H)-one : A quinolone that is 1,2-dihydroquinoline substituted by an oxo group at position 2.		2.0610monohydroxyquinoline;
quinolone		bacterial xenobiotic metabolite
4-toluenesulfonamide
4-toluenesulfonamide: RN given refers to parent cpd. toluene-4-sulfonamide : A sulfonamide that is benzenesulfonamide bearing a methyl group at position 4.		2.0610sulfonamide
3-methylsalicylic acid
3-methylsalicylic acid : A monohydroxybenzoic acid consisting of salicylic acid carrying a methyl group at the 3-position.		2.0610monohydroxybenzoic acidbacterial xenobiotic metabolite
lawsone
lawsone: a molluscacide from leaves of Lawsonia inermis L. topical sunscreening agent; structure; powdered leaves of Lawsonia inermis(Lythraceae) used as brown hair dye. lawsone : 1,4-Naphthoquinone carrying a hydroxy function at C-2. It is obtained from the leaves of Lawsonia inermis.		2.0610
5-methylsalicylic acid
[no description available]		2.0610
quinaldic acid
[no description available]		2.0610quinolinemonocarboxylic acidhuman metabolite;
Saccharomyces cerevisiae metabolite
2,5-pyridinedicarboxylic acid
2,5-Pyridinedicarboxylic acid: RN given refers to parent cpd. isocinchomeronic acid : A pyridinedicarboxylic acid carrying carboxy groups at positions 2 and 5.		2.0610pyridinedicarboxylic acid
maltol
maltol: found in bark of young larch trees; isolated from Passiflora incarnata; possesses depressant properties in mice; potentiates hexobarbital-induced narcosis & inhibits spontaneous motor activity; structure		2.06104-pyranonesmetabolite
gamma-resorcylic acid
[no description available]		2.0610dihydroxybenzoic acidmetabolite
dipicolinic acid
dipicolinic acid : A pyridinedicarboxylic acid carrying two carboxy groups at positions 2 and 6.		2.0610pyridinedicarboxylic acidbacterial metabolite
tropolone
Tropolone: A seven-membered aromatic ring compound. It is structurally related to a number of naturally occurring antifungal compounds (ANTIFUNGAL AGENTS).. tropolone : A cyclic ketone that is cyclohepta-2,4,6-trien-1-one substituted by a hydroxy group at position 2. It is a toxin produced by the agricultural pathogen Burkholderia plantarii.		2.0610alpha-hydroxy ketone;
cyclic ketone;
enol		bacterial metabolite;
fungicide;
toxin
malondialdehyde
Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.		1.9710dialdehydebiomarker
1,2-dihydroxynaphthalene
1,2-dihydroxynaphthalene: RN given refers to parent cpd		2.0610naphthalenediolmouse metabolite
8-aminoquinoline
[no description available]		2.0610
6-methyluracil
6-methyluracil: RN given refers to unlabeled cpd; structure. 6-methyluracil : A pyrimidone that is uracil with a methyl group at position 6.		2.0610pyrimidonemetabolite
2-pyrrolecarboxylic acid
2-pyrrolecarboxylic acid: hypocalcemic action; structure. pyrrole-2-carboxylic acid : A pyrrolecarboxylic acid that is 1H-pyrrole carrying a carboxy substituent at position 2.		2.0610pyrrolecarboxylic acidplant metabolite
8-hydroxy-2-methylquinoline
8-hydroxy-2-methylquinoline: structure in first source		2.0610hydroxyquinoline
2-(2'-hydroxyphenyl)benzoxazole
2-(2'-hydroxyphenyl)benzoxazole: structure in first source. 2-(1,3-benzoxazol-2-yl)phenol : A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazole substituted by a 2-hydroxyphenyl group at position 2.		2.06101,3-benzoxazoles;
phenols		geroprotector
3-hydroxypicolinic acid
[no description available]		2.0610monocarboxylic acid;
monohydroxypyridine		MALDI matrix material
8-hydroxyquinoline N-oxide
8-hydroxyquinoline N-oxide : A quinoline N-oxide carrying a hydroxy substituent at position 8.		2.0610monohydroxyquinoline;
quinoline N-oxide
clopyralid
clopyralid : An organochlorine pesticide having a 3,6-dichlorinated picolinic acid structure.		2.0610organochlorine pesticide;
pyridines		herbicide
2-(2-hydroxyphenyl)benzothiazole
2-(1,3-benzothiazol-2-yl)phenol : A member of the class of benzothiazoles that is 1,3-benzothiazole substituted by a 2-hydroxyphenyl group at position 2.		2.0610benzothiazoles;
phenols		geroprotector
ethyl maltol
ethyl maltol: structure given in first source		2.0610pyranone
cadmium
Cadmium: An element with atomic symbol Cd, atomic number 48, and atomic weight 112.41. It is a metal and ingestion will lead to CADMIUM POISONING.. elemental cadmium : An element in the zinc group of the periodic table with atomic number 48, atomic mass 112, M.P. 321degreeC, and B.P. 765degreeC). An odourless, tasteless, and highly poisonous soft, ductile, lustrous metal with electropositive properties. It has eight stable isotopes: (106)Cd, (108)Cd,(110)Cd, (111)Cd, (112)Cd, (113)Cd, (114)Cd and (116)Cd, with (112)Cd and (114)Cd being the most common.		1.9710cadmium molecular entity;
zinc group element atom
2,3-dihydroxypyridine
2,3-dihydroxypyridine: affects thyroid function. pyridine-2,3-diol : A dihydroxypyridine in which the two hydroxy groups are located at positions 2 and 3.		2.0610dihydroxypyridine
acetylacetone
acetylacetone : A beta-diketone that is pentane in which the hydrogens at positions 2 and 4 are replaced by oxo groups.		2.0610beta-diketone
5-fluorosalicylic acid
5-fluorosalicylic acid: structure given in first source; product from action of alkaline phosphatase on 5-fluorosalicyl phosphate; forms highly fluorescent terbium ternary complex		2.0610
pyromeconic acid
pyromeconic acid: from herb Dengzhanhua; structure		2.4120
2-hydroxypyrimidine
pyrimidone : A pyrimidine carrying one or more oxo substituents.. pyrimidin-2-ol : The hydroxypyrimidine that is pyrimidine mono-substituted at C-2 by a hydroxy group.		2.0610hydroxypyrimidineelectron donor;
Lewis base
allomaltol
allomaltol: structure in first source		2.0610
1-hydroxy-2(1h)-pyridinone
1-hydroxy-2(1H)-pyridinone: structure in first source		2.4120
2,2'-dipicolylamine
2,2'-dipicolylamine: structure in first source		2.0610
8-hydroxy-2-quinolinecarboxylic acid
[no description available]		2.0610quinolines
3-chloro-2,4-pentanedione
3-chloro-2,4-pentanedione: structure in first source		2.0610
cp094
1,2-diethyl-3-hydroxypyridin-4-one: structure given in first source		3.0950
cp 102
CP 102: structure in first source		2.3920
1-methyl-3-hydroxypyridine-2-one
[no description available]		2.0610
cp 41
CP 41: structure in first source		2.3920
1-ethyl-2-methyl-3-hydroxypyridin-4-one
[no description available]		3.2560
1-(ethan-1-ol)-2-methyl-3-hydroxypyridin-4-one
1-(ethan-1-ol)-2-methyl-3-hydroxypyridin-4-one: structure given in first source		2.3920
2-acetylcyclopentanone
2-acetylcyclopentanone: an enolate-forming compound that is protective against electrophilic drugs; structure in first source		2.0610
3,4-dihydroxypyridine
3-hydroxy-4(1H)-pyridone: structure in first source		2.39204-pyridones;
dihydroxypyridine
1-propyl-2-methyl-3-hydroxypyrid-4-one
[no description available]		2.940
8-(methylsulfonylamino)quinoline
8-(methylsulfonylamino)quinoline: has diabetogenic properties; structure given in first source		2.0610
1,4,7-triazacyclononane
1,4,7-triazacyclononane: structure given in first source		2.0610azacycloalkane;
crown amine;
saturated organic heteromonocyclic parent
methylthiouracil
Methylthiouracil: A thiourea antithyroid agent that inhibits the synthesis of thyroid hormone. It is used in the treatment of hyperthyroidism.		2.0610pyrimidone
4,6-dimethyl-2-thiopyrimidine
4,6-dimethyl-2-thiopyrimidine: structure		2.0610
thiouracil
Thiouracil: Occurs in seeds of Brassica and Crucifera species. Thiouracil has been used as antithyroid, coronary vasodilator, and in congestive heart failure although its use has been largely supplanted by other drugs. It is known to cause blood dyscrasias and suspected of terato- and carcinogenesis.. thiouracil : A nucleobase analogue that is uracil in which the oxo group at C-2 is replaced by a thioxo group.		2.0610nucleobase analogue;
thiocarbonyl compound		antithyroid drug;
metabolite
4-thiouracil
[no description available]		2.0610
3-hydroxy-2-methyl-4h-pyran-4-thione
3-hydroxy-2-methyl-4H-pyran-4-thione: inhibits Bla2 beta-lactamase; structure in first source		2.0610
indium
Indium: A metallic element, atomic number 49, atomic weight 114.818, symbol In. It is named from its blue line in the spectrum.. indium atom : A metallic element first identified and named from the brilliant indigo (Latin indicum) blue line in its flame spectrum.		1.9710boron group element atom
2,4-diaminohypoxanthine
2,4-diaminohypoxanthine: do not confuse abbreviation DAHP with various dehydro-deoxy-arabino-heptulosonic acid phosphates which also use DAHP; RN given refers to parent cpd; structure		2.0610hydroxypyrimidine
pyridine-2-aldoxime
pyridine-2-aldoxime: RN given refers to parent cpd		1.9810
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