cp 102 profile

CP 102: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	86379
CHEMBL ID	307343
SCHEMBL ID	4754379
MeSH ID	M0280769

Synonym
cp 102
CHEMBL307343
cp-102 ,
2-ethyl-3-hydroxy-1-(2-hydroxyethyl)pyridin-4-one
2-ethyl-3-hydroxy-1-(2-hydroxyethyl)-4(1h)-pyridinone
126055-13-8
4(1h)-pyridinone, 2-ethyl-3-hydroxy-1-(2-hydroxyethyl)-
SCHEMBL4754379
DTXSID60155060
cp102
2-ethyl-3-hydroxy-1-(2-hydroxyethyl)-1,4-dihydropyridin-4-one
BFA05513
EN300-5255209
Z1251353023

Bioassays (19)

Assay ID	Title	Year	Journal	Article
AID26620	Compound was tested for equilibrium constants (pKa1) spectrophotometrically.	1998	Journal of medicinal chemistry, Aug-27, Volume: 41, Issue:18	Synthesis, physicochemical properties, and evaluation of N-substituted-2-alkyl-3-hydroxy-4(1H)-pyridinones.
AID193977	The amount of iron-binding when iron chelator administered in the bile duct-cannulated rats.	1998	Journal of medicinal chemistry, Aug-27, Volume: 41, Issue:18	Synthesis, physicochemical properties, and evaluation of N-substituted-2-alkyl-3-hydroxy-4(1H)-pyridinones.
AID179654	Compound was tested in vivo for Iron mobilization efficacy against hepatocytes in normal fasted rats (loaded with [59Fe]-Ferritin).	1999	Journal of medicinal chemistry, Nov-18, Volume: 42, Issue:23	Synthesis, physicochemical characterization, and biological evaluation of 2-(1'-hydroxyalkyl)-3-hydroxypyridin-4-ones: novel iron chelators with enhanced pFe(3+) values.
AID26251	Partition coefficient (logD7.4) for iron(III) complexes	1998	Journal of medicinal chemistry, Aug-27, Volume: 41, Issue:18	Synthesis, physicochemical properties, and evaluation of N-substituted-2-alkyl-3-hydroxy-4(1H)-pyridinones.
AID193842	The amount iron excretion in the bile duct-cannulated rats when iron chelator administered orally at dose 132 mg/kg	1998	Journal of medicinal chemistry, Aug-27, Volume: 41, Issue:18	Synthesis, physicochemical properties, and evaluation of N-substituted-2-alkyl-3-hydroxy-4(1H)-pyridinones.
AID15965	Partition coefficient (logD7.4)	1999	Journal of medicinal chemistry, Nov-18, Volume: 42, Issue:23	Synthesis, physicochemical characterization, and biological evaluation of 2-(1'-hydroxyalkyl)-3-hydroxypyridin-4-ones: novel iron chelators with enhanced pFe(3+) values.
AID26827	Compound was tested for equilibrium constants (pKa2) of the (carboxyalkyl) pyridinone corresponds to the carboxylic function potentiometrically	1998	Journal of medicinal chemistry, Aug-27, Volume: 41, Issue:18	Synthesis, physicochemical properties, and evaluation of N-substituted-2-alkyl-3-hydroxy-4(1H)-pyridinones.
AID229913	Spectrophotometric selectivity ratio for pKa2 and pKa3	1998	Journal of medicinal chemistry, Aug-27, Volume: 41, Issue:18	Synthesis, physicochemical properties, and evaluation of N-substituted-2-alkyl-3-hydroxy-4(1H)-pyridinones.
AID26260	Partition coefficient (logD7.4)	1998	Journal of medicinal chemistry, Aug-27, Volume: 41, Issue:18	Synthesis, physicochemical properties, and evaluation of N-substituted-2-alkyl-3-hydroxy-4(1H)-pyridinones.
AID26619	Compound was tested for equilibrium constants (pKa1) potentiometrically	1998	Journal of medicinal chemistry, Aug-27, Volume: 41, Issue:18	Synthesis, physicochemical properties, and evaluation of N-substituted-2-alkyl-3-hydroxy-4(1H)-pyridinones.
AID28984	Partition coefficient (logD7.4)	1993	Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17	Synthesis, physicochemical properties, and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4(1H)-pyridinones: orally active iron chelators with clinical potential.
AID26574	Compound was determined for their affinity constants(log K3) with Fe(III) complex.	1998	Journal of medicinal chemistry, Aug-27, Volume: 41, Issue:18	Synthesis, physicochemical properties, and evaluation of N-substituted-2-alkyl-3-hydroxy-4(1H)-pyridinones.
AID26552	Compound was determined for their affinity constants(log K1) with Fe(III) complex.	1998	Journal of medicinal chemistry, Aug-27, Volume: 41, Issue:18	Synthesis, physicochemical properties, and evaluation of N-substituted-2-alkyl-3-hydroxy-4(1H)-pyridinones.
AID231251	Potentiometric selectivity ratio for pKa2 and pKa3	1998	Journal of medicinal chemistry, Aug-27, Volume: 41, Issue:18	Synthesis, physicochemical properties, and evaluation of N-substituted-2-alkyl-3-hydroxy-4(1H)-pyridinones.
AID19829	Partition coefficient (logP)	1999	Journal of medicinal chemistry, Nov-18, Volume: 42, Issue:23	Synthesis, physicochemical characterization, and biological evaluation of 2-(1'-hydroxyalkyl)-3-hydroxypyridin-4-ones: novel iron chelators with enhanced pFe(3+) values.
AID193974	The amount iron excretion in the bile duct-cannulated rats when iron chelator administered subcutaneously at dose 132 mg/kg	1998	Journal of medicinal chemistry, Aug-27, Volume: 41, Issue:18	Synthesis, physicochemical properties, and evaluation of N-substituted-2-alkyl-3-hydroxy-4(1H)-pyridinones.
AID26828	Compound was tested for equilibrium constants (pKa2) of the (carboxyalkyl) pyridinone corresponds to the carboxylic function spectrophotometrically..	1998	Journal of medicinal chemistry, Aug-27, Volume: 41, Issue:18	Synthesis, physicochemical properties, and evaluation of N-substituted-2-alkyl-3-hydroxy-4(1H)-pyridinones.
AID26570	Compound was determined for their affinity constants(log K2) with Fe(III) complex.	1998	Journal of medicinal chemistry, Aug-27, Volume: 41, Issue:18	Synthesis, physicochemical properties, and evaluation of N-substituted-2-alkyl-3-hydroxy-4(1H)-pyridinones.
AID23941	Compound was determined for their EDTA competition value(log beta3) of affinity constants.	1998	Journal of medicinal chemistry, Aug-27, Volume: 41, Issue:18	Synthesis, physicochemical properties, and evaluation of N-substituted-2-alkyl-3-hydroxy-4(1H)-pyridinones.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	5 (71.43)	18.2507
2000's	1 (14.29)	29.6817
2010's	1 (14.29)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
catechol [no description available]	1.98	1	catechols	allelochemical; genotoxin; plant metabolite
oxyquinoline Oxyquinoline: An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.. quinolin-8-ol : A monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes.	1.98	1	monohydroxyquinoline	antibacterial agent; antifungal agrochemical; antiseptic drug; iron chelator
acetaminophen Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.. paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.	2.08	1	acetamides; phenols	antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; cyclooxygenase 3 inhibitor; environmental contaminant; ferroptosis inducer; geroprotector; hepatotoxic agent; human blood serum metabolite; non-narcotic analgesic; non-steroidal anti-inflammatory drug; xenobiotic
acetohydroxamic acid acetohydroxamic acid: urease inhibitor. oxime : Compounds of structure R2C=NOH derived from condensation of aldehydes or ketones with hydroxylamine. Oximes from aldehydes may be called aldoximes; those from ketones may be called ketoximes.. N-hydroxyacetimidic acid : A carbohydroximic acid consisting of acetimidic acid having a hydroxy group attached to the imide nitrogen.. acetohydroxamic acid : A member of the class of acetohydroxamic acids that is acetamide in which one of the amino hydrogens has been replaced by a hydroxy group.	1.98	1	acetohydroxamic acids; carbohydroximic acid	algal metabolite; EC 3.5.1.5 (urease) inhibitor
bromhexine Bromhexine: A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744). bromhexine : A substituted aniline that is 2,4-dibromoaniline which is substituted at position 6 by a [cyclohexyl(methyl)amino]methyl group. It is used (as the monohydrochloride salt) as a mucolytic for the treatment of respiratory disorders associated with productive cough (i.e. a cough characterised by the production of sputum).	2.08	1	organobromine compound; substituted aniline; tertiary amino compound	mucolytic
deferiprone Deferiprone: A pyridone derivative and iron chelator that is used in the treatment of IRON OVERLOAD in patients with THALASSEMIA.. deferiprone : A member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia.	2.68	3	4-pyridones	iron chelator; protective agent
deferoxamine Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.. desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.	1.98	1	acyclic desferrioxamine	bacterial metabolite; ferroptosis inhibitor; iron chelator; siderophore
mannitol [no description available]	2.08	1	mannitol	allergen; antiglaucoma drug; compatible osmolytes; Escherichia coli metabolite; food anticaking agent; food bulking agent; food humectant; food stabiliser; food thickening agent; hapten; metabolite; osmotic diuretic; sweetening agent
tricalcium phosphate tricalcium phosphate: a form of tricalcium phosphate used as bioceramic bone replacement material; see also records for alpha-tricalcium phosphate, beta-tricalcium phosphate, calcium phosphate; apatitic tricalcium phosphate Ca9(HPO4)(PO4)5(OH) is the calcium orthophosphate leading to beta tricalcium phosphate Ca3(PO4)2 (b-TCP). calcium phosphate : A calcium salt composed of calcium and phosphate/diphosphate ions; present in milk and used for the mineralisation of calcified tissues.	2.08	1	calcium phosphate
glycerol 1-stearate glycerol 1-stearate: isolated from the young fronds of the bracken fern Pteridium aquilinum; structure in first source. rac-1-monostearoylglycerol : A rac-1-monoacylglycerol composed of equal amounts of 3-stearoyl-sn-glycerol and 1-stearoyl-sn-glycerol.. 1-monostearoylglycerol : A 1-monoglyceride that has stearoyl as the acyl group.	2.08	1	1-acylglycerol 18:0; rac-1-monoacylglycerol	algal metabolite; Caenorhabditis elegans metabolite
transferrin Transferrin: An iron-binding beta1-globulin that is synthesized in the LIVER and secreted into the blood. It plays a central role in the transport of IRON throughout the circulation. A variety of transferrin isoforms exist in humans, including some that are considered markers for specific disease states.	1.99	1
pyromeconic acid pyromeconic acid: from herb Dengzhanhua; structure	1.98	1
1-hydroxy-2(1h)-pyridinone 1-hydroxy-2(1H)-pyridinone: structure in first source	1.98	1
1-methyl-2-ethyl-3-hydroxypyridin-4-one [no description available]	2.39	2
cp094 1,2-diethyl-3-hydroxypyridin-4-one: structure given in first source	2.91	4
cp 41 CP 41: structure in first source	2.91	4
1-ethyl-2-methyl-3-hydroxypyridin-4-one [no description available]	2.39	2
1-(ethan-1-ol)-2-methyl-3-hydroxypyridin-4-one 1-(ethan-1-ol)-2-methyl-3-hydroxypyridin-4-one: structure given in first source	2.39	2
calcium phosphate, dibasic, dihydrate calcium phosphate, dibasic, dihydrate: Molecular formula CaHPO(4)-2(H2O)	2.08	1	calcium salt; hydrate
3,4-dihydroxypyridine 3-hydroxy-4(1H)-pyridone: structure in first source	1.98	1	4-pyridones; dihydroxypyridine
1-propyl-2-methyl-3-hydroxypyrid-4-one [no description available]	2.39	2
cellulose DEAE-Cellulose: Cellulose derivative used in chromatography, as ion-exchange material, and for various industrial applications.	2.08	1	glycoside
pyridine-2-aldoxime pyridine-2-aldoxime: RN given refers to parent cpd	1.98	1

cp 102

Description

Cross-References

Synonyms (14)

Bioassays (19)

Research

Studies (7)

Study Types

cp 102

Description

Cross-References

Synonyms (14)

Bioassays (19)

Research

Studies (7)

Study Types

Related Drugs (23)

Related Conditions (0)