Compounds > 2,4-difluoroaniline
Page last updated: 2024-12-05

2,4-difluoroaniline

Description

2,4-difluoroaniline: chemical intermediate manufactured by the Halex process; RN given refers to parent cpd; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9709
CHEMBL ID1423658
SCHEMBL ID11425
MeSH IDM0127881

Synonyms (65)

Synonym
BIDD:GT0098
benzenamine, 2,4-difluoro-
SDCCGMLS-0066219.P001
ccris 4621
brn 2802556
einecs 206-687-5
nsc 10297
ai3-52650
aniline, 2,4-difluoro-
2,4-difluorobenzenamine
aniline,4-difluoro-
367-25-9
nsc-10297
2,4-difluroaniline
2,4-difluoroaniline
benzenamine,4-difluoro-
nsc10297
NCGC00091684-01
2,4-difluoroaniline, 99%
AC-10532
2,4-difluorophenylamine
76563-56-9
inchi=1/c6h5f2n/c7-4-1-2-6(9)5(8)3-4/h1-3h,9h2
cepcpxllfxpzgw-uhfffaoysa-
D1508
AKOS000119718
A25254
2,4-difluoro-anilin;aniline, 2,4-difluoro-;benzenamine, 2,4-difluoro-
NCGC00091684-02
unii-40p93l7kwd
4-12-00-01112 (beilstein handbook reference)
40p93l7kwd ,
ec 206-687-5
tox21_200620
dtxcid905064
dtxsid6025064 ,
NCGC00258174-01
cas-367-25-9
2,4-difluoro-phenylamine
FT-0601172
AM20040294
STL264190
SCHEMBL11425
difluoroaniline, 2,4-
2,4-difluoroaniline [mi]
2,4difluoroaniline
2,4-difluoro aniline
2, 4-difluoroaniline
2,4 -difluoroaniline
2,4-di-fluoroaniline
2,4-difluoro-aniline
2,4 difluoro aniline
2.4-difluoroaniline
(2,4-difluorophenyl)amine
W-106593
CHEMBL1423658
CS-W020027
PS-9155
mfcd00007648
F2182-0028
n-boc-3-methylnipecoticacidethylester
CCG-302504
Q27258348
EN300-19930
Z104476120

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" However, by-products of disinfection may exert toxic effects."( Subacute toxicity assessment of water disinfection byproducts on zebrafish.
Baska, F; Csenki, Z; Gustafson, R; Hegyi, A; Kis, R; Kovács, R; Rácz, G; Sujbert, L; Szende, B; Urbányi, B; Zsákovics, I, 2012)		0.38

Dosage Studied

ExcerptRelevanceReference
" Experiments using rats dosed by the oral route as a model system show that measurement of methaemoglobin content provides a very rapid and simple monitoring method, but is not very sensitive."( 2,4-Difluoroaniline and 4-fluoroaniline exposure: monitoring by methaemoglobin and urine analyses.
Eadsforth, CV; Logan, CJ; Morrison, BJ; Warburton, PA, 1984)		1.71
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (4)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency39.81070.011212.4002100.0000AID1030
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency69.35760.003041.611522,387.1992AID1159552
aryl hydrocarbon receptorHomo sapiens (human)Potency61.81500.000723.06741,258.9301AID743085
Nuclear receptor ROR-gammaHomo sapiens (human)Potency10.59090.026622.448266.8242AID651802
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (13)

Processvia Protein(s)Taxonomy
negative regulation of transcription by RNA polymerase IINuclear receptor ROR-gammaHomo sapiens (human)
xenobiotic metabolic processNuclear receptor ROR-gammaHomo sapiens (human)
regulation of glucose metabolic processNuclear receptor ROR-gammaHomo sapiens (human)
regulation of steroid metabolic processNuclear receptor ROR-gammaHomo sapiens (human)
intracellular receptor signaling pathwayNuclear receptor ROR-gammaHomo sapiens (human)
circadian regulation of gene expressionNuclear receptor ROR-gammaHomo sapiens (human)
cellular response to sterolNuclear receptor ROR-gammaHomo sapiens (human)
positive regulation of circadian rhythmNuclear receptor ROR-gammaHomo sapiens (human)
regulation of fat cell differentiationNuclear receptor ROR-gammaHomo sapiens (human)
positive regulation of DNA-templated transcriptionNuclear receptor ROR-gammaHomo sapiens (human)
adipose tissue developmentNuclear receptor ROR-gammaHomo sapiens (human)
T-helper 17 cell differentiationNuclear receptor ROR-gammaHomo sapiens (human)
regulation of transcription by RNA polymerase IINuclear receptor ROR-gammaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (10)

Processvia Protein(s)Taxonomy
RNA polymerase II cis-regulatory region sequence-specific DNA bindingNuclear receptor ROR-gammaHomo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificNuclear receptor ROR-gammaHomo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specificNuclear receptor ROR-gammaHomo sapiens (human)
DNA-binding transcription factor activityNuclear receptor ROR-gammaHomo sapiens (human)
protein bindingNuclear receptor ROR-gammaHomo sapiens (human)
oxysterol bindingNuclear receptor ROR-gammaHomo sapiens (human)
zinc ion bindingNuclear receptor ROR-gammaHomo sapiens (human)
ligand-activated transcription factor activityNuclear receptor ROR-gammaHomo sapiens (human)
sequence-specific double-stranded DNA bindingNuclear receptor ROR-gammaHomo sapiens (human)
nuclear receptor activityNuclear receptor ROR-gammaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (4)

Processvia Protein(s)Taxonomy
nucleusNuclear receptor ROR-gammaHomo sapiens (human)
nucleoplasmNuclear receptor ROR-gammaHomo sapiens (human)
nuclear bodyNuclear receptor ROR-gammaHomo sapiens (human)
chromatinNuclear receptor ROR-gammaHomo sapiens (human)
nucleusNuclear receptor ROR-gammaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (14.29)18.7374
1990's1 (14.29)18.2507
2000's0 (0.00)29.6817
2010's4 (57.14)24.3611
2020's1 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 32.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index32.50 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.42 (4.65)
Search Engine Demand Index36.32 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (32.50)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
methanol
Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.		2.0710alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound		amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite
4-fluoroaniline
4-fluoroaniline: chemical intermediate manufactured by the Halex process; RN given refers to parent cpd; structure given in first source. 4-fluoroaniline : A primary arylamine that is the derivative of aniline in which the hydrogen at position 4 has been substituted by fluorine. It is used as an intermediate in the manufacture of pharmaceuticals, herbicides and plant growth regulators.		2.4220fluoroaniline;
primary arylamine
cps 49
CPS 49: has antineoplastic activity		2.0710
ConditionIndicatedRelationship StrengthStudiesTrials
Methemoglobinemia
The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)		01.9610
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