Compounds > dibenzyl ether
Page last updated: 2024-12-05

dibenzyl ether

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Dibenzyl ether is a colorless liquid with a sweet, aromatic odor. It is used as a solvent and in the synthesis of other organic compounds. Dibenzyl ether is synthesized by reacting benzyl chloride with sodium hydroxide in the presence of a catalyst. Dibenzyl ether is a relatively unreactive compound, but it can be oxidized to benzophenone. Dibenzyl ether is studied for its potential applications in various fields, including organic synthesis, pharmaceuticals, and materials science. The compound is also used as a model system for studying the properties of ethers. Dibenzyl ether is a relatively safe compound, but it should be handled with care as it can be an irritant to the skin and eyes.'

benzyl ether : A compound of formula PhCH2OR (R =/= H). [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

dibenzyl ether : A benzyl ether in which the oxygen atom is connected to two benzyl groups. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID7657
CHEMBL ID152299
CHEBI ID87411
SCHEMBL ID27380
MeSH IDM0205998

Synonyms (87)

Synonym
BIDD:ER0268
nsc5931
wln: r1o1r
benzyl ether
benzene,1'-[oxybis(methylene)]bis-
benzyl oxide
ba (plasticizer)
103-50-4
plastikator ba
nsc-5931
dibenzyl ether
dibenzylether
nsc 5931
1,1'-(oxybis(methylene))bisbenzene
brn 1911156
ether, dibenzyl
ai3-02269
plasticator ba
benzene, 1,1'-(oxybis(methylene))bis-
hsdb 6030
einecs 203-118-2
fema no. 2371
fema number 2371
ccris 6085
dibenzylether [czech]
ba (van)
benzyl oxide [czech]
benzene, 1,1'-oxybis(methylene-
1,1-(oxybis(methylene))bisbenzene
1,1-oxybismethylene, bis benzene
benzene, 1,1'-[oxybis(methylene)]bis-
ether,dibenzyl
1,1'-[oxybis(methylene)]dibenzene
inchi=1/c14h14o/c1-3-7-13(8-4-1)11-15-12-14-9-5-2-6-10-14/h1-10h,11-12h
NCGC00091363-01
1,1-oxybis methylene, bis benzene
benzyl ether, >=98%, fcc, fg
benzyl ether, 98%
B0418
1-benzyloxymethylbenzene(benzyl ether)
chebi:87411 ,
CHEMBL152299
smr001216521
MLS001050086
phenylmethoxymethylbenzene
A800755
NCGC00091363-02
ec 203-118-2
2o6cno27rj ,
4-06-00-02240 (beilstein handbook reference)
unii-2o6cno27rj
tox21_200903
dtxsid5025819 ,
dtxcid005819
NCGC00258457-01
cas-103-50-4
[(benzyloxy)methyl]benzene
FT-0624653
AKOS015914994
dibenzyl ether [fcc]
dibenzyl ether [fhfi]
tribenoside impurity d [ep impurity]
benzyl ether [mi]
dibenzyl ether [hsdb]
bn2o
mono-benzyl ether
benzylether
SCHEMBL27380
(oxybis(methylene))dibenzene
Q-200956
[(benzyloxy)methyl]benzene #
mfcd00004780
dibenzyl ether, analytical standard
dibenzyl ether, purum, >=98.0% (gc)
tribenoside impurity d, european pharmacopoeia (ep) reference standard
1,1'-[oxybis(methylene)]bisbenzene, 9ci
fema 2371
phenylmethoxy-methyl-benzene
benzyl ether, 8ci
oxybis(methylene)dibenzene
Q11309584
ethyl?benzo[d]thiazole-6-carboxylate
BS-14196
dibenzyl ester
tribenoside impurity d
CS-W010535
?benzyl ether
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
benzyl etherA compound of formula PhCH2OR (R =/= H).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (5)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
thyroid stimulating hormone receptorHomo sapiens (human)Potency39.81070.001318.074339.8107AID926; AID938
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency50.11870.000214.376460.0339AID588532
pregnane X nuclear receptorHomo sapiens (human)Potency35.48130.005428.02631,258.9301AID720659
estrogen nuclear receptor alphaHomo sapiens (human)Potency1.02040.000229.305416,493.5996AID743075
Nuclear receptor ROR-gammaHomo sapiens (human)Potency26.60320.026622.448266.8242AID651802
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (13)

Processvia Protein(s)Taxonomy
negative regulation of transcription by RNA polymerase IINuclear receptor ROR-gammaHomo sapiens (human)
xenobiotic metabolic processNuclear receptor ROR-gammaHomo sapiens (human)
regulation of glucose metabolic processNuclear receptor ROR-gammaHomo sapiens (human)
regulation of steroid metabolic processNuclear receptor ROR-gammaHomo sapiens (human)
intracellular receptor signaling pathwayNuclear receptor ROR-gammaHomo sapiens (human)
circadian regulation of gene expressionNuclear receptor ROR-gammaHomo sapiens (human)
cellular response to sterolNuclear receptor ROR-gammaHomo sapiens (human)
positive regulation of circadian rhythmNuclear receptor ROR-gammaHomo sapiens (human)
regulation of fat cell differentiationNuclear receptor ROR-gammaHomo sapiens (human)
positive regulation of DNA-templated transcriptionNuclear receptor ROR-gammaHomo sapiens (human)
adipose tissue developmentNuclear receptor ROR-gammaHomo sapiens (human)
T-helper 17 cell differentiationNuclear receptor ROR-gammaHomo sapiens (human)
regulation of transcription by RNA polymerase IINuclear receptor ROR-gammaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (10)

Processvia Protein(s)Taxonomy
RNA polymerase II cis-regulatory region sequence-specific DNA bindingNuclear receptor ROR-gammaHomo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificNuclear receptor ROR-gammaHomo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specificNuclear receptor ROR-gammaHomo sapiens (human)
DNA-binding transcription factor activityNuclear receptor ROR-gammaHomo sapiens (human)
protein bindingNuclear receptor ROR-gammaHomo sapiens (human)
oxysterol bindingNuclear receptor ROR-gammaHomo sapiens (human)
zinc ion bindingNuclear receptor ROR-gammaHomo sapiens (human)
ligand-activated transcription factor activityNuclear receptor ROR-gammaHomo sapiens (human)
sequence-specific double-stranded DNA bindingNuclear receptor ROR-gammaHomo sapiens (human)
nuclear receptor activityNuclear receptor ROR-gammaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (4)

Processvia Protein(s)Taxonomy
nucleusNuclear receptor ROR-gammaHomo sapiens (human)
nucleoplasmNuclear receptor ROR-gammaHomo sapiens (human)
nuclear bodyNuclear receptor ROR-gammaHomo sapiens (human)
chromatinNuclear receptor ROR-gammaHomo sapiens (human)
nucleusNuclear receptor ROR-gammaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Research

Studies (17)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (5.88)18.2507
2000's5 (29.41)29.6817
2010's9 (52.94)24.3611
2020's2 (11.76)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 52.89

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index52.89 (24.57)
Research Supply Index2.89 (2.92)
Research Growth Index4.95 (4.65)
Search Engine Demand Index78.19 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (52.89)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (5.88%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other16 (94.12%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
benzyl alcohol
Benzyl Alcohol: A colorless liquid with a sharp burning taste and slight odor. It is used as a local anesthetic and to reduce pain associated with LIDOCAINE injection. Also, it is used in the manufacture of other benzyl compounds, as a pharmaceutic aid, and in perfumery and flavoring.. hydroxytoluene : Any member of the class of toluenes carrying one or more hydroxy substituents.. benzyl alcohol : An aromatic alcohol that consists of benzene bearing a single hydroxymethyl substituent.. aromatic alcohol : Any alcohol in which the alcoholic hydroxy group is attached to a carbon which is itself bonded to an aromatic ring.. aromatic primary alcohol : Any primary alcohol in which the alcoholic hydroxy group is attached to a carbon which is itself bonded to an aromatic ring.		3.9530benzyl alcoholsantioxidant;
fragrance;
metabolite;
solvent
chlorine
chloride : A halide anion formed when chlorine picks up an electron to form an an anion.		2.110halide anion;
monoatomic chlorine		cofactor;
Escherichia coli metabolite;
human metabolite
formaldehyde
paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy		2.0810aldehyde;
one-carbon compound		allergen;
carcinogenic agent;
disinfectant;
EC 3.5.1.4 (amidase) inhibitor;
environmental contaminant;
Escherichia coli metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
glycerol
Moon: The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil.		2.0810alditol;
triol		algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent
urea
pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.		2.4820isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
benzyl benzoate
benzyl benzoate: structure; acarosan, a moist powder composed of wetted cellulose and benzyl benzoate, is used on carpets as an acaricide. benzyl benzoate : A benzoate ester obtained by the formal condensation of benzoic acid with benzyl alcohol. It has been isolated from the plant species of the genus Polyalthia.		3.6120benzoate ester;
benzyl ester		acaricide;
plant metabolite;
scabicide
ether
Ether: A mobile, very volatile, highly flammable liquid used as an inhalation anesthetic and as a solvent for waxes, fats, oils, perfumes, alkaloids, and gums. It is mildly irritating to skin and mucous membranes.. ether : An organooxygen compound with formula ROR, where R is not hydrogen.. diethyl ether : An ether in which the oxygen atom is linked to two ethyl groups.		7.4920ether;
volatile organic compound		inhalation anaesthetic;
non-polar solvent;
refrigerant
sucrose
Saccharum: A plant genus of the family POACEAE widely cultivated in the tropics for the sweet cane that is processed into sugar.		2.0810glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent
methylene chloride
Methylene Chloride: A chlorinated hydrocarbon that has been used as an inhalation anesthetic and acts as a narcotic in high concentrations. Its primary use is as a solvent in manufacturing and food technology.. dichloromethane : A member of the class of chloromethanes that is methane in which two of the hydrogens have been replaced by chlorine. A dense, non-flammible colourless liquid at room temperature (b.p. 40degreeC, d = 1.33) which is immiscible with water, it is widely used as a solvent, a paint stripper, and for the removal of caffeine from coffee and tea.		2.2110chloromethanes;
volatile organic compound		carcinogenic agent;
polar aprotic solvent;
refrigerant
methylphenylsulfide
thioanisole : An aryl sulfide that is thiophenol in which the hydrogen of the thiol group has been replaced by a methyl group.		2.610aryl sulfide;
benzenes
tetrahydrofuran
oxolane : A cyclic ether that is butane in which one hydrogen from each methyl group is substituted by an oxygen.		3.2150cyclic ether;
oxolanes;
saturated organic heteromonocyclic parent;
volatile organic compound		polar aprotic solvent
benzyl sulfide
[no description available]		2.610
molybdenum
Molybdenum: A metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.95. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase.		2.4110chromium group element atommicronutrient
ferric chloride
ferric chloride: RN given refers to cpd with MF of Fe-Cl3; used to induce experimental arterial thrombosis to evaluate antithrombotic agents		2.110iron coordination entityastringent;
Lewis acid
p-tert-butylphenolformaldehyde resin
p-tert-butylphenolformaldehyde resin: irritant; used in glues; RN given refers to parent cpd; PTBP plastic is the macromolecular form of the resin		210
D-fructopyranose
[no description available]		2.0810cyclic hemiketal;
D-fructose;
fructopyranose		sweetening agent
ConditionIndicatedRelationship StrengthStudiesTrials
Injuries, Spinal Cord
[description not available]		02.2110
Spinal Cord Injuries
Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).		02.2110
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		02.0810
Dehydration
The condition that results from excessive loss of water from a living organism.		02.0710
Allergic Contact Dermatitis
[description not available]		0210
Dermatitis, Allergic Contact
A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.		0210
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		01.9810
Electrolytes
Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)		01.9810