zymosterol profile

Zymosterol is a sterol precursor to cholesterol. It is a C30 compound with a double bond at the C24 position, unlike cholesterol, which has a double bond at the C5 position. Zymosterol is synthesized in the liver and other tissues from the precursor lanosterol. It is a substrate for the enzyme C24-reductase, which reduces the double bond at the C24 position to form cholesterol. Zymosterol is also a potent inhibitor of the enzyme squalene synthase, which catalyzes the first committed step in cholesterol biosynthesis. This inhibition is believed to be responsible for the anti-inflammatory and anti-cancer effects of zymosterol. Studies have shown that zymosterol can inhibit the growth of various cancer cells, including breast cancer, prostate cancer, and melanoma. Zymosterol is also being investigated as a potential treatment for Alzheimer's disease, as it has been shown to reduce the formation of amyloid plaques in the brain. Zymosterol is a valuable tool for studying the biosynthesis and regulation of cholesterol, and it may have potential therapeutic applications.'

ID Source	ID
PubMed CID	92746
CHEMBL ID	4171014
CHEBI ID	18252
SCHEMBL ID	95293
MeSH ID	M0064944

Synonym
CHEBI:18252
zymostrol
delta8, 24-cholestadien-3beta-ol
128-33-6
delta8,24-cholestadien-3beta-ol
zymosterol ,
C05437
5alpha-cholesta-8,24-dien-3beta-ol
LMST01010066
bdbm50280400
chembl4171014 ,
(3s,5s,10s,13r,14r,17r)-10,13-dimethyl-17-[(2r)-6-methylhept-5-en-2-yl]-2,3,4,5,6,7,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-ol
8,24(5-alpha)-cholestadien-3-beta-ol
einecs 204-880-9
5-alpha-cholesta-8,24-dien-3-beta-ol
unii-pu2755pt4o
pu2755pt4o ,
(3.beta.,5.alpha.)-cholesta-8,24-dien-3-ol
SCHEMBL95293
CGSJXLIKVBJVRY-XTGBIJOFSA-N
cholest-8,24-dien-3b-ol
(3b,5a)- cholesta-8,24-dien-3-ol
(3s,10s,13r,14r,17r)-10,13-dimethyl-17-((r)-6-methylhept-5-en-2-yl)-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-3-ol
Q3576424
DTXSID201028211

Excerpt	Relevance	Reference
" Gene dosage experiments using the sphingolipid long chain sphingoid base (LCB) hydroxylase gene, SUR2, suggest that erg26-1 cells may accumulate LCB, thus placing one point of sterol regulation of sphingolipid synthesis possibly at the level of ceramide metabolism."	( Sterol-dependent regulation of sphingolipid metabolism in Saccharomyces cerevisiae. Baudry, K; Germann, M; McDonough, V; Nickels, JT; Stukey, J; Swain, E, 2002)	0.31

Role	Description
human metabolite	Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
Saccharomyces cerevisiae metabolite	Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae).
mouse metabolite	Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
3beta-sterol	A sterol in which the hydroxy group at position 3 has beta- configuration.
cholestanoid	Any steroid based on a cholestane skeleton and its derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathway	Proteins	Compounds
Metabolism	1496	1108
Metabolism of lipids	500	463
Metabolism of steroids	111	135
Cholesterol biosynthesis	22	49
Bloch pathway	4	10
Kandutsch-Russell pathway	4	10
Steroid Biosynthesis	21	42
Smith-Lemli-Opitz Syndrome (SLOS)	21	42
CHILD Syndrome	21	42
Desmosterolosis	21	42
Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2)	21	42
Lysosomal Acid Lipase Deficiency (Wolman Disease)	21	42
Ibandronate Action Pathway	21	43
Simvastatin Action Pathway	21	43
Pravastatin Action Pathway	21	43
Rosuvastatin Action Pathway	21	43
Alendronate Action Pathway	21	43
Hypercholesterolemia	21	42
Lovastatin Action Pathway	21	43
Zoledronate Action Pathway	21	43
Cerivastatin Action Pathway	21	43
Risedronate Action Pathway	21	43
Pamidronate Action Pathway	21	43
Fluvastatin Action Pathway	21	43
Atorvastatin Action Pathway	21	43
Cholesteryl Ester Storage Disease	21	42
Hyper-IgD Syndrome	21	42
Mevalonic Aciduria	21	42
Wolman Disease	21	42
Cholesterol biosynthesis and metabolism CE(14:0)	22	50
Cholesterol biosynthesis and metabolism CE(10:0)	22	50
Cholesterol Biosynthesis and Metabolism CE(12:0)	22	50
Cholesterol Biosynthesis and Metabolism CE(16:0)	22	50
Cholesterol biosynthesis and metabolism CE(18:0)	22	50
Cholesterol metabolism with Bloch and Kandutsch-Russell pathways	0	39
Cholesterol Biosynthesis and Metabolism	22	48
Bloch Pathway (Cholesterol Biosynthesis)	9	29
cholesterol biosynthesis I	4	28
zymosterol biosynthesis	0	20
Renz2020 - GEM of Human alveolar macrophage with SARS-CoV-2	0	490
Cholesterol biosynthesis with skeletal dysplasias	0	14
Cholesterol synthesis disorders	0	15
Cholesterol metabolism	2	14
Enterocyte cholesterol metabolism	1	11
Cholesterol biosynthesis pathway in hepatocytes	11	37
Ergosterol biosynthesis	3	32
superpathway of ergosterol biosynthesis I	21	56
ergosterol biosynthesis I	5	14
zymosterol biosynthesis	8	26
cholesterol biosynthesis I	9	44
cholesterol biosynthesis III (via desmosterol)	9	39
superpathway of cholesterol biosynthesis	21	78
superpathway of ergosterol biosynthesis	22	56
ergosterol biosynthesis	5	14
superpathway of sterol biosynthesis	0	50
Biochemical pathways: part I	0	466
Cholesterol biosynthesis I	1	18
Cholesterol biosynthesis II (via 24,25-dihydrolanosterol)	1	17
Cholesterol biosynthesis III (via desmosterol)	1	18

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Nuclear receptor ROR-gamma	Homo sapiens (human)	EC50 (µMol)	0.1100	0.0200	0.7035	9.0000	AID1505269
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
negative regulation of transcription by RNA polymerase II	Nuclear receptor ROR-gamma	Homo sapiens (human)
xenobiotic metabolic process	Nuclear receptor ROR-gamma	Homo sapiens (human)
regulation of glucose metabolic process	Nuclear receptor ROR-gamma	Homo sapiens (human)
regulation of steroid metabolic process	Nuclear receptor ROR-gamma	Homo sapiens (human)
intracellular receptor signaling pathway	Nuclear receptor ROR-gamma	Homo sapiens (human)
circadian regulation of gene expression	Nuclear receptor ROR-gamma	Homo sapiens (human)
cellular response to sterol	Nuclear receptor ROR-gamma	Homo sapiens (human)
positive regulation of circadian rhythm	Nuclear receptor ROR-gamma	Homo sapiens (human)
regulation of fat cell differentiation	Nuclear receptor ROR-gamma	Homo sapiens (human)
positive regulation of DNA-templated transcription	Nuclear receptor ROR-gamma	Homo sapiens (human)
adipose tissue development	Nuclear receptor ROR-gamma	Homo sapiens (human)
T-helper 17 cell differentiation	Nuclear receptor ROR-gamma	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Nuclear receptor ROR-gamma	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nuclear receptor ROR-gamma	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Nuclear receptor ROR-gamma	Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specific	Nuclear receptor ROR-gamma	Homo sapiens (human)
DNA-binding transcription factor activity	Nuclear receptor ROR-gamma	Homo sapiens (human)
protein binding	Nuclear receptor ROR-gamma	Homo sapiens (human)
oxysterol binding	Nuclear receptor ROR-gamma	Homo sapiens (human)
zinc ion binding	Nuclear receptor ROR-gamma	Homo sapiens (human)
ligand-activated transcription factor activity	Nuclear receptor ROR-gamma	Homo sapiens (human)
sequence-specific double-stranded DNA binding	Nuclear receptor ROR-gamma	Homo sapiens (human)
nuclear receptor activity	Nuclear receptor ROR-gamma	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
nucleus	Nuclear receptor ROR-gamma	Homo sapiens (human)
nucleoplasm	Nuclear receptor ROR-gamma	Homo sapiens (human)
nuclear body	Nuclear receptor ROR-gamma	Homo sapiens (human)
chromatin	Nuclear receptor ROR-gamma	Homo sapiens (human)
nucleus	Nuclear receptor ROR-gamma	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Assay ID	Title	Year	Journal	Article
AID1505269	Agonist activity at Gal4-fused RORgammat DNA binding domain (unknown origin) expressed in 293T cells assessed as SRC1 coactivator recruitment in presence of ursolic acid by TR-FRET assay	2018	Journal of medicinal chemistry, Jul-26, Volume: 61, Issue:14	Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Agonists as Potential Small Molecule Therapeutics for Cancer Immunotherapy.
AID1502696	Induction of sterol accumulation in human HL60 cells at 0.1 uM incubated for 24 hrs by GC-MS analysis	2017	European journal of medicinal chemistry, Nov-10, Volume: 140	New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	10 (31.25)	18.7374
1990's	8 (25.00)	18.2507
2000's	6 (18.75)	29.6817
2010's	6 (18.75)	24.3611
2020's	2 (6.25)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (3.03%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	32 (96.97%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
hydrogen Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.	1.99	1	elemental hydrogen; elemental molecule; gas molecular entity	antioxidant; electron donor; food packaging gas; fuel; human metabolite
isopentenyl pyrophosphate isopentenyl pyrophosphate: substrate for isopentenyl pyrophosphate isomerase; RN given refers to unlabeled cpd; a nonpeptide mycobacterial antigen that stimulates gamma delta T cells. isopentenyl diphosphate : A prenol phosphate comprising 3-methylbut-3-en-1-ol having an O-diphosphate substituent.	1.96	1	prenol phosphate	antigen; antioxidant; epitope; Escherichia coli metabolite; mouse metabolite; phosphoantigen
3-methylcholanthrene Methylcholanthrene: A carcinogen that is often used in experimental cancer studies.. 3-methylcholanthrene : A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.	1.97	1	ortho- and peri-fused polycyclic arene	aryl hydrocarbon receptor agonist; carcinogenic agent
ketoconazole 1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.	1.98	1	dichlorobenzene; dioxolane; ether; imidazoles; N-acylpiperazine; N-arylpiperazine
corticosterone [no description available]	1.96	1	11beta-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; C21-steroid; glucocorticoid; primary alpha-hydroxy ketone	human metabolite; mouse metabolite
triparanol Triparanol: Antilipemic agent with high ophthalmic toxicity. According to Merck Index, 11th ed, the compound was withdrawn from the market in 1962 because of its association with the formation of irreversible cataracts.	2.42	2	stilbenoid	anticoronaviral agent
pregnenolone [no description available]	1.96	1	20-oxo steroid; 3beta-hydroxy-Delta(5)-steroid; C21-steroid	human metabolite; mouse metabolite
trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride: An anti-cholesteremic agent that inhibits delta 7-reductase, delta 14 reductase, and sterol biosynthesis.	1.96	1
fluorobenzenes Fluorobenzenes: Derivatives of BENZENE that contain FLUORINE.. monofluorobenzene : The simplest member of the class of monofluorobenzenes that is benzene carrying a single fluoro substituent.. fluorobenzenes : Any fluoroarene that is a benzene or a substituted benzene carrying at least one fluoro group.	2.25	1	monofluorobenzenes	NMR chemical shift reference compound
2,3,4,5,6-pentafluorophenol 2,3,4,5,6-pentafluorophenol: RN given refers to parent cpd; structure given in first source	2.25	1
ethionine L-ethionine : An S-ethylhomocysteine that has S-configuration at the chiral centre.	1.96	1	S-ethylhomocysteine	antimetabolite; carcinogenic agent
phenyl acetate phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.	2.66	3	benzenes; phenyl acetates
25-hydroxycholesterol [no description available]	3.27	1	25-hydroxy steroid; oxysterol	human metabolite
tomatidine tomatidine: RN given refers to (3beta,5alpha,22beta,25S)-isomer; structure. tomatidine : A 3beta-hydroxy steroid resulting from the substitution of the 3beta-hydrogen of tomatidane by a hydroxy group.	2.11	1	3beta-hydroxy steroid; azaspiro compound; oxaspiro compound
lathosterol lathosterol: RN given refers to (3beta,5alpha)-isomer. 5alpha-cholest-7-en-3beta-ol : A cholestanoid that is (5alpha)-cholest-7-ene substituted by a beta-hydroxy group at position 3.	2.59	2	3beta-sterol; C27-steroid; cholestanoid; Delta(7)-sterol	human metabolite; mouse metabolite
trifluoperazine hydrochloride [no description available]	2.15	1	hydrochloride
cycloartenol [no description available]	2.01	1	3beta-sterol; pentacyclic triterpenoid; phytosterols	plant metabolite
fenpropimorph [no description available]	2	1	alkylbenzene
5-pregnene-3,20-diol 5-pregnene-3,20-diol: RN given refers to (3 beta,20 alpha)-isomer	2.15	1	corticosteroid hormone
zymostenol zymostenol: RN given refers to (3beta,5alpha)-isomer; RN for cpd without isomeric designation not available 9/88. 5alpha-cholest-8-en-3beta-ol : A cholestanoid that is 5alpha-cholestane substituted by a beta-hydroxy group at position 3.	7.38	2	3beta-sterol; cholestanoid	human metabolite; mouse metabolite
22-hydroxycholesterol [no description available]	1.96	1	cholanoid
4,4-dimethyl-5-alpha-cholesta-(8,24)-dien-3-beta-ol 4,4-dimethyl-5-alpha-cholesta-(8,24)-dien-3-beta-ol: RN given refers to (3beta,5alpha)-isomer. 14-demethyllanosterol : A 3beta-sterol formed formally by loss of a methyl group from the 14-position of lanosterol.	2.01	1	3beta-sterol	human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
(22r)-22-hydroxycholesterol (22R)-22-hydroxycholesterol : An oxysterol that is the 22R-hydroxy derivative of cholesterol.	3.27	1	22-hydroxy steroid; 3beta-hydroxy-Delta(5)-steroid; oxysterol
lanosterol [no description available]	3.25	6	14alpha-methyl steroid; 3beta-sterol; tetracyclic triterpenoid	bacterial metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite
mevalonic acid Mevalonic Acid: A dihydroxy monocarboxylic acid and precursor in the biosynthetic pathway known as the mevalonate pathway, which produces terpenes and steroids that are vital for diverse cellular functions.. mevalonic acid : A racemate composed of equimolar amounts of (R)- and (S)-mevalonic acid.. (R)-mevalonic acid : The (R)-enantiomer of mevalonic acid.	2.37	2	3,5-dihydroxy-3-methylpentanoic acid
7-dehydrocholesterol [no description available]	2.7	3	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; cholestanoid; Delta(5),Delta(7)-sterol	human metabolite; mouse metabolite
desmosterol Desmosterol: An intermediate in the synthesis of cholesterol.. desmosterol : A cholestanoid that is cholesta-5,24-diene substituted by a beta-hydroxy group at position 3. It is an intermediate metabolite obtained during the synthesis of cholesterol.	4.37	6	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; C27-steroid; cholestanoid	human metabolite; mouse metabolite
fecosterol [no description available]	1.96	1	3beta-sterol	Saccharomyces cerevisiae metabolite
24,25-dihydrolanosterol lanostenol: RN given refers to (3beta)-isomer; structure. 24,25-dihydrolanosterol : A 3beta-sterol formed from lanosterol by reduction across the C-24-C-25 double bond.	1.96	1	3beta-sterol; tetracyclic triterpenoid	human metabolite; mouse metabolite
ergosterol [no description available]	2.66	3	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; ergostanoid; phytosterols	fungal metabolite; Saccharomyces cerevisiae metabolite
squalene Addavax: an oil-water nanoemulsion and adjuvant containing squalene, Tween 80, and sorbitane trioleate	2.39	2	triterpene	human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite
cholecalciferol Cholecalciferol: Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.. calciol : A hydroxy seco-steroid that is (5Z,7E)-9,10-secocholesta-5,7,10(19)-triene in which the pro-S hydrogen at position 3 has been replaced by a hydroxy group. It is the inactive form of vitamin D3, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D3), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D3), the active hormone.	2.25	1	D3 vitamins; hydroxy seco-steroid; seco-cholestane; secondary alcohol; steroid hormone	geroprotector; human metabolite
2,3-oxidosqualene 2,3-oxidosqualene: an oxidized derivative of SQUALENE that can fold in several ways: chair-boat-chair-boat to LANOSTEROL; chair-chair-chair-boat to dammarane; or all chair to hopane and on to cycloartenol; RN given refers to (all-Z)-isomer. 2,3-epoxysqualene : A squalene triterpenoid obtained by formal epoxidation across the 2,3 C=C bond of squalene.	2.02	1	epoxide; squalene triterpenoid
1-palmitoyl-2-oleoylphosphatidylcholine 1-palmitoyl-2-oleoylphosphatidylcholine: RN given refers to (Z)-isomer	2.11	1
sr 31747 SR 31747: a sigma receptor antagonist and steroid isomerase inhibitor with immunosuppressive and anti-inflammatory activities; structure given in first source	2	1
u 18666a 3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one: inhibits cycloartenol synthase. 3beta-(2-diethylaminoethoxy)androst-5-en-17-one hydrochloride : A hydrochloride obtained by reaction of 3beta-(2-diethylaminoethoxy)androst-5-en-17-one with one equivalent of hydrochloric acid. It is a cholesterol synthesis and transport inhibitor.	2.15	1	hydrochloride	antiviral agent; EC 1.3.1.72 (Delta(24)-sterol reductase) inhibitor; Hedgehog signaling pathway inhibitor; nicotinic antagonist; sterol biosynthesis inhibitor
azacosterol Azacosterol: Diaza derivative of cholesterol which acts as a hypocholesteremic agent by blocking delta-24-reductase, which causes the accumulation of desmosterol.	1.97	1
phytosterols Phytosterols: A class of organic compounds known as sterols or STEROIDS derived from plants.. phytosterols : Sterols similar to cholesterol which occur in plants and vary only in carbon side chains and/or presence or absence of a double bond.	2.01	1
phosphatidylcholines Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.	2.11	1	1,2-diacyl-sn-glycero-3-phosphocholine
s-adenosylmethionine (R)-S-adenosyl-L-methionine : An S-adenosyl-L-methionine that has R-configuration.. S-adenosyl-L-methionine zwitterion : A zwitterionic tautomer of S-adenosyl-L-methionine arising from shift of the proton from the carboxy group to the amino group.. (R)-S-adenosyl-L-methionine zwitterion : An S-adenosyl-L-methionine zwitterion that has R-configuration; major species at pH 7.3.. (S)-S-adenosyl-L-methionine zwitterion : An S-adenosyl-L-methionine zwitterion that has S-configuration; major species at pH 7.3.. S-adenosyl-L-methionine : A sulfonium compound that is the S-adenosyl derivative of L-methionine. It is an intermediate in the metabolic pathway of methionine.	2.01	1	organic cation; sulfonium compound	coenzyme; cofactor; human metabolite; micronutrient; Mycoplasma genitalium metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
cholenic acid dimethylamide cholenic acid dimethylamide: binds LXRalpha receptor; structure in first source	2.15	1
glycolipids [no description available]	2.11	1
teriflunomide [no description available]	2.31	1	(trifluoromethyl)benzenes; aromatic amide; enamide; enol; nitrile; secondary carboxamide	drug metabolite; EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitor; hepatotoxic agent; non-steroidal anti-inflammatory drug; tyrosine kinase inhibitor
tomatine Tomatine: An alkaloid that occurs in the extract of leaves of wild tomato plants. It has been found to inhibit the growth of various fungi and bacteria. It is used as a precipitating agent for steroids. (From The Merck Index, 11th ed). tomatine : A steroid alkaloid that is tomatidine in which the hydroxy group at position 3 is linked to lycotetraose, a tetrasaccharide composed of two units of D-glucose, one unit of D-xylose, and one unit of D-galactose.	2.11	1
cholestyramine resin Cholestyramine Resin: A strongly basic anion exchange resin whose main constituent is polystyrene trimethylbenzylammonium Cl(-) anion.	1.95	1

Condition	Relationship Strength	Studies
Benign Neoplasms [description not available]	3.09	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	3.09	1
Central Nervous System Disease [description not available]	2.31	1
Clinically Isolated CNS Demyelinating Syndrome [description not available]	2.31	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.31	1
Central Nervous System Diseases Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.	2.31	1
Demyelinating Diseases Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.	2.31	1
Cancer of Liver [description not available]	1.98	1
Experimental Hepatoma [description not available]	1.98	1
Liver Neoplasms Tumors or cancer of the LIVER.	1.98	1
Kahler Disease [description not available]	1.96	1
Multiple Myeloma A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.	1.96	1

zymosterol

Cross-References

Synonyms (25)

Research Excerpts

Dosage Studied

Roles (3)

Drug Classes (2)

Pathways (54)

Protein Targets (1)

Activation Measurements

Biological Processes (13)

Molecular Functions (10)

Ceullar Components (4)

Bioassays (2)

Research

Studies (32)

Market Indicators

Research Demand Index: 34.70

Study Types