| ID Source | ID |
|---|---|
| PubMed CID | 701 |
| CHEMBL ID | 31596 |
| SCHEMBL ID | 41804 |
| MeSH ID | M0305422 |
| Synonym |
|---|
| MLS002177803 , |
| smr001261797 |
| ethyl alpha-methylacetylacetate |
| nsc 1102 |
| unii-ne9woz20je |
| ethyl alpha-acetylpropionate |
| alpha-methylacetoacetic ester |
| ai3-05606 |
| ne9woz20je , |
| einecs 210-179-9 |
| acetoacetic acid, 2-methyl-, ethyl ester |
| butanoic acid, 2-methyl-3-oxo-, ethyl ester |
| ethyl-2-methyl acetoacetate |
| NCGC00090968-01 |
| ethyl methylacetoacetate |
| .alpha.-methylacetoacetic ester |
| ethyl .alpha.-methylacetoacetate |
| ethyl .alpha.-methylacetylacetate |
| nsc1102 |
| ETHYL-2-METHYLACETOACETATE , |
| ethyl 2-methylacetoacetate |
| ethyl 2-methyl-3-oxobutanoate , |
| ethyl 2-acetylpropionate |
| ethyl .alpha.-acetylpropionate |
| nsc-1102 |
| 609-14-3 |
| ethyl 2-methyl-3-oxobutyrate |
| ethyl 2-methylacetoacetate, 90% |
| E-8300 |
| CHEMBL31596 |
| AKOS005138021 |
| M0698 |
| 2-acetylpropionic acid ethyl ester |
| 2-methylacetoacetic acid ethyl ester |
| A832951 |
| NCGC00090968-02 |
| ethyl-2-methyl-acetoacetate |
| NCGC00258690-01 |
| dtxsid2033493 , |
| dtxcid0013493 |
| cas-609-14-3 |
| tox21_201138 |
| FT-0613000 |
| AM20100481 |
| ethyl2-methylacetoacetate |
| SCHEMBL41804 |
| ethyl 2-methyl-3-oxidanylidene-butanoate |
| cid_701 |
| bdbm74254 |
| 3-keto-2-methyl-butyric acid ethyl ester |
| ethyl 2-methyl-acetoacetate |
| ethyl-alpha-methylacetoacetate |
| 2-methyl-3-oxobutanoic acid ethyl ester |
| 2-methyl acetoacetic acid ethyl ester |
| 2-methyl-3-oxo-butanoic acid ethyl ester |
| ethyl 2-methylaceto-acetate |
| alpha-methylacetoacetic acid ethyl ester |
| 2-methyl-3-oxo-butyric acid ethyl ester |
| ethyl 2-methyl-3-oxo-butyrate |
| ethyl 2-methylacetoaceate |
| 2-methyl acetoacetic ethyl ester |
| alpha-methyl-acetoacetic acid ethyl ester |
| 2-methyl-3-oxobutyric acid ethyl ester |
| ethyl ester of 2-methyl-3-oxobutanoic acid |
| ethyl 3-oxo-2-methylbutanoate |
| ethyl (+/-)-2-methylacetoacetate |
| acetoacetic acid, .alpha.-methyl-, ethyl ester |
| ethyl 2-acetylpropanoate |
| 1522-45-8 |
| F0001-1597 |
| CS-W004822 |
| mfcd00009164 |
| GS-3290 |
| SY005677 |
| F11259 |
| STL196835 |
| Q27284827 |
| BP-31062 |
| ethyl2-methyl-3-oxobutanoate |
| EN300-49163 |
| Z586248936 |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| WRN | Homo sapiens (human) | Potency | 15.8489 | 0.1683 | 31.2583 | 100.0000 | AID651768 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 354.8130 | 0.0316 | 37.5844 | 354.8130 | AID743255 |
| TDP1 protein | Homo sapiens (human) | Potency | 6.5131 | 0.0008 | 11.3822 | 44.6684 | AID686978; AID686979 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 48.9036 | 0.0007 | 14.5928 | 83.7951 | AID1259369 |
| 67.9K protein | Vaccinia virus | Potency | 1.5673 | 0.0001 | 8.4406 | 100.0000 | AID720579; AID720580 |
| IDH1 | Homo sapiens (human) | Potency | 0.9200 | 0.0052 | 10.8652 | 35.4813 | AID686970 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 74.9780 | 0.0006 | 27.2152 | 1,122.0200 | AID651741 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 89.1251 | 0.1000 | 28.9256 | 213.3130 | AID588591 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 100.0000 | 0.0316 | 22.3146 | 100.0000 | AID588579 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 0.0047 | 0.0266 | 22.4482 | 66.8242 | AID651802 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| ORF73 | Human gammaherpesvirus 8 | EC50 (µMol) | 75.0000 | 0.0600 | 8.1346 | 32.1400 | AID435023 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| nucleus | Nuclear receptor ROR-gamma | Homo sapiens (human) |
| nucleoplasm | Nuclear receptor ROR-gamma | Homo sapiens (human) |
| nuclear body | Nuclear receptor ROR-gamma | Homo sapiens (human) |
| chromatin | Nuclear receptor ROR-gamma | Homo sapiens (human) |
| nucleus | Nuclear receptor ROR-gamma | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID167125 | Eye irritation potential accessed using Draize in vivo rabbit eye irritation test | 2003 | Journal of medicinal chemistry, Apr-10, Volume: 46, Issue:8 | Mapping property distributions of molecular surfaces: algorithm and evaluation of a novel 3D quantitative structure-activity relationship technique. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||