Compounds > mogroside v

Page last updated: 2024-11-13

mogroside v

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

mogroside V: cucurbitane type sweet triterpene glycoside from fruit of Momordica grosvenori Swingle; RN given refers to (3beta,9beta,10alpha,11alpha,24R-all D)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Momordica	genus	A plant genus of the family CUCURBITACEAE. It is a source of momordin.[MeSH]	Cucurbitaceae	The gourd plant family of the order Violales, subclass Dilleniidae, class Magnoliopsida. It is sometimes placed in its own order, Cucurbitales. 'Melon' generally refers to CUCUMIS; CITRULLUS; or MOMORDICA.[MeSH]

Cross-References

ID Source	ID
PubMed CID	24721270
CHEMBL ID	1829228
SCHEMBL ID	4572693
MeSH ID	M0123642

Synonyms (23)

Synonym
mogrol-3-o-(beta-d-glucopyranosyl (1-6)-beta-d-glucopyranoside)-24-o-((beta-d-glucopyranosyl (1-2))-(beta-d-glucopyranosyl(1-6))-beta-d-glucopyranoside)
zff6z51tur ,
unii-zff6z51tur
beta-d-glucopyranoside, (3beta,9beta,10alpha,11alpha,24r)-3-((6-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl)oxy)-11,25-dihydroxy-9-methyl-19-norlanost-5-en-24-yl o-beta-d-glucopyranosyl-(1-2)-o-(beta-d-glucopyranosyl-(1-6))-
88901-36-4
mogroside v
CHEMBL1829228
S3815
(1s,4r,9beta,11alpha,24r)-1-{[6-o-(beta-d-glucopyranosyl)-beta-d-glucopyranosyl]oxy}-11,25-dihydroxy-9,10,14-trimethyl-4,9-cyclo-9,10-secocholest-5-en-24-yl beta-d-glucopyranosyl-(1->2)-[beta-d-glucopyranosyl-(1->6)]-beta-d-glucopyranoside
GHBNZZJYBXQAHG-KUVSNLSMSA-N
SCHEMBL4572693
Q-100878
mogroside-v
mfcd00238649
CS-0009025
HY-N0502
CCG-270667
AS-56272
AKOS037645029
.beta.-d-glucopyranoside, (3.beta.,9.beta.,10.alpha.,11.alpha.,24r)-3-((6-o-.beta.-d-glucopyranosyl-.beta.-d-glucopyranosyl)oxy)-11,25-dihydroxy-9-methyl-19-norlanost-5-en-24-yl o-.beta.-d-glucopyranosyl-(1->2)-o-(.beta.-d-glucopyranosyl-(1->6))-
mogrol-3-o-(.beta.-d-glucopyranosyl (1-6)-.beta.-d-glucopyranoside)-24-o-((.beta.-d-glucopyranosyl (1-2))-(.beta.-d-glucopyranosyl(1-6))-.beta.-d-glucopyranoside)
mogroside v [usp-rs]
(3.beta.,9.beta.,10.alpha.,11.alpha.,24r)-3-((6-o-.beta.-d-glucopyranosyl-.beta.-d-glucopyranosyl)oxy)-11,25-dihydroxy-9-methyl-19-norlanost-5-en-24-yl o-.beta.-d-glucopyranosyl-(1->2)-o-(.beta.-d-glucopyranosyl-(1->6))-.beta.-d-glucopyranoside

Research Excerpts

Overview

Mogroside V is a common natural sweetener extracted from the fruit of Siraitia grosvenorii. Its taste should be improved for marketability.

Excerpt	Reference	Relevance
"Mogroside V is a triterpene glycoside isolated from S."	( Protective activity of mogroside V against ovalbumin-induced experimental allergic asthma in Kunming mice. Gao, Y; Lv, F; Pan, C; Qian, B; Song, JL; Wang, H; Zhou, Y, 2019)	1.55
"Mogroside V is a common natural sweetener extracted from the fruit of Siraitia grosvenorii, but its taste should be improved for marketability."	( Dekkera bruxellensis, a beer yeast that specifically bioconverts mogroside extracts into the intense natural sweetener siamenoside I. Chen, YC; Huang, ST; Lai, YJ; Lo, YC; Lu, TJ; Wang, R, 2019)	1.24
"Mogroside V is a triterpenoid glycoside from Siraitia grosvenorii."	( Mogroside V Inhibits Hyperglycemia-induced Lung Cancer Cells Metastasis through Reversing EMT and Damaging Cytoskeleton. Chen, J; Chen, Q; Jiang, C; Jiao, D; Li, Y; Song, J; Tang, X, 2019)	2.68

Toxicity

Excerpt	Reference	Relevance
" There were no significant adverse effects on any of these measures."	( Subchronic 90-day oral (Gavage) toxicity study of a Luo Han Guo mogroside extract in dogs. Heimbach, J; Qin, X; Ronggan, L; Shouji, G; Xiaojian, S; Yuxian, W; Zhunian, T, 2006)	0.33

Pharmacokinetics

Excerpt	Reference	Relevance
" A sensitive, robust and selective liquid chromatography tandem with mass spectrometry (LC-MS/MS) was developed and validated for the determination and pharmacokinetic investigation of mogroside V in rat plasma."	( Quantitative determination of mogroside V in rat plasma by LC-MS/MS and its application to a pharmacokinetic study. Qu, X; Tao, L; Yan, H; Zhang, S; Zhou, L, 2018)	0.96

Bioavailability

Excerpt	Reference	Relevance
"The objective of this work was to investigate the capacity of mogroside V (MOG-V), a food additive, as a novel carrier to improve the bioavailability and liver distribution of silybin (SLY)."	( Evaluation of Mogroside V as a Promising Carrier in Drug Delivery: Improving the Bioavailability and Liver Distribution of Silybin. Chen, Y; Gong, C; Luo, Y; Mo, L; Song, T; Wei, M; Wu, C; Zhang, J, 2020)	1.16

Dosage Studied

Excerpt	Relevance	Reference
" MG therapy had no effect on normal mice, except that low dosage MG could up-regulate the IL-4 expression levels."	( Effect of a Siraitia grosvenori extract containing mogrosides on the cellular immune system of type 1 diabetes mellitus mice. Bijun, X; Liegang, L; Ping, Y; Weijun, C; Xiangyang, Q, 2006)	0.33

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay ID	Title	Year	Journal	Article
AID620412	Activation of AMPK in human HepG2 cells assessed as increase in AMPK phosphorylation at 1 to 20 uM after 30 mins by Western blotting	2011	Bioorganic & medicinal chemistry, Oct-01, Volume: 19, Issue:19	Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (46)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (4.35)	18.7374
1990's	0 (0.00)	18.2507
2000's	7 (15.22)	29.6817
2010's	21 (45.65)	24.3611
2020's	16 (34.78)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 36.99

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	36.99 (24.57)
Research Supply Index	3.87 (2.92)
Research Growth Index	4.94 (4.65)
Search Engine Demand Index	73.21 (26.88)
Search Engine Supply Index	3.00 (0.95)

This Compound (36.99)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (4.26%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	45 (95.74%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
lactic acid Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed). 2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.	2.41	1	2-hydroxy monocarboxylic acid	algal metabolite; Daphnia magna metabolite
berberine [no description available]	2.06	1	alkaloid antibiotic; berberine alkaloid; botanical anti-fungal agent; organic heteropentacyclic compound	antilipemic drug; antineoplastic agent; antioxidant; EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitor; EC 1.1.1.21 (aldehyde reductase) inhibitor; EC 1.13.11.52 (indoleamine 2,3-dioxygenase) inhibitor; EC 1.21.3.3 (reticuline oxidase) inhibitor; EC 2.1.1.116 [3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase] inhibitor; EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor; EC 2.7.11.10 (IkappaB kinase) inhibitor; EC 3.1.1.4 (phospholipase A2) inhibitor; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor; EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; geroprotector; hypoglycemic agent; metabolite; potassium channel blocker
letrozole [no description available]	7.41	1	nitrile; triazoles	antineoplastic agent; EC 1.14.14.14 (aromatase) inhibitor
corticosterone [no description available]	2.6	1	11beta-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; C21-steroid; glucocorticoid; primary alpha-hydroxy ketone	human metabolite; mouse metabolite
9,10-dimethyl-1,2-benzanthracene 9,10-Dimethyl-1,2-benzanthracene: Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.. 7,12-dimethyltetraphene : A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.	2.01	1	ortho-fused polycyclic arene; tetraphenes	carcinogenic agent
rotenone Derris: A plant genus of the family FABACEAE. The root is a source of rotenoids (ROTENONE) and flavonoids. Some species of Pongamia have been reclassified to this genus and some to MILLETTIA. Some species of Deguelia have been reclassified to this genus.. rotenoid : Members of the class of tetrahydrochromenochromene that consists of a cis-fused tetrahydrochromeno[3,4-b]chromene skeleton and its substituted derivatives. The term was originally restricted to natural products, but is now also used to describe semi-synthetic and fully synthetic compounds.	2.41	1	organic heteropentacyclic compound; rotenones	antineoplastic agent; metabolite; mitochondrial NADH:ubiquinone reductase inhibitor; phytogenic insecticide; piscicide; toxin
tetradecanoylphorbol acetate Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.	2.01	1	acetate ester; diester; phorbol ester; tertiary alpha-hydroxy ketone; tetradecanoate ester	antineoplastic agent; apoptosis inducer; carcinogenic agent; mitogen; plant metabolite; protein kinase C agonist; reactive oxygen species generator
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	3.87	3	D-glucopyranose	epitope; mouse metabolite
peroxynitrous acid Peroxynitrous Acid: A potent oxidant synthesized by the cell during its normal metabolism. Peroxynitrite is formed from the reaction of two free radicals, NITRIC OXIDE and the superoxide anion (SUPEROXIDES).	2.01	1	nitrogen oxoacid
stevioside stevioside: Kaurene glucoside from leaves of Stevia rebaudiana; 300 times as sweet as sugar. stevioside : A diterpene glycoside that is rubusoside in which the hydroxy group at position 2 of the allylic beta-D-glucoside has been converted to the corresponding beta-D-glucoside. It is a natural herbal sweetener that is 250-300 times sweeter than sucrose (though with a bitter aftertaste), extracted from the Stevia rebaudiana plant native to South America.. diterpene glycoside : A terpene glycoside in which the terpene moiety is a diterpenoid.	3.18	1	beta-D-glucoside; bridged compound; diterpene glycoside; ent-kaurane diterpenoid; tetracyclic diterpenoid	anti-inflammatory agent; antineoplastic agent; antioxidant; hypoglycemic agent; plant metabolite; sweetening agent
glycosides [no description available]	3.21	5
curcumin Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.. curcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.	7.6	1	aromatic ether; beta-diketone; diarylheptanoid; enone; polyphenol	anti-inflammatory agent; antifungal agent; antineoplastic agent; biological pigment; contraceptive drug; dye; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; EC 1.1.1.21 (aldehyde reductase) inhibitor; EC 1.1.1.25 (shikimate dehydrogenase) inhibitor; EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor; EC 1.8.1.9 (thioredoxin reductase) inhibitor; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; flavouring agent; food colouring; geroprotector; hepatoprotective agent; immunomodulator; iron chelator; ligand; lipoxygenase inhibitor; metabolite; neuroprotective agent; nutraceutical; radical scavenger
ovalbumin Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.	7.66	2
ex 527 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide: structure in first source. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide : A member of the class of carbazoles that is 2,3,4,9-tetrahydro-1H-carbazole which is substituted at position 1 by an aminocarbohyl group and at position 6 by a chlorine.	2.21	1	carbazoles; monocarboxylic acid amide; organochlorine compound
dinoprostone prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.	2.21	1	prostaglandins E	human metabolite; mouse metabolite; oxytocic
dizocilpine maleate Dizocilpine Maleate: A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.. dizocilpine maleate : A maleate salt obtained by reaction of dizocilpine with one equivalent of maleic acid.	2.25	1	maleate salt; tetracyclic antidepressant	anaesthetic; anticonvulsant; neuroprotective agent; nicotinic antagonist; NMDA receptor antagonist
beta-escin [no description available]	3.06	4
rebaudioside a rebaudioside A: glucoside isolated from the leaves of the paraguayan shrub, Stevia rebaudiana; has taste properties superior to stevioside; structure in first source. rebaudioside A : A rebaudioside that is rubusoside in which the hydroxy groups at positions 3 and 4 of the beta-D-glucopyranosyloxy group at the 13alpha position have both been converted to the corresponding beta-D-glucopyranoside.	3.18	1	beta-D-glucoside; rebaudioside; tetracyclic diterpenoid	sweetening agent
mogrol mogrol : A tetracyclic triterpenoid that is cucurbitadienol in which the side-chain double bond (position 24-25) has undergone formal oxidation to introduce hydroxy groups at positions 24 and 25 (the 24R stereoisomer). It is a biometabolite of mogrosides found in Siraitia grosvenorii.	2.06	1	hydroxy seco-steroid; tetracyclic triterpenoid	antineoplastic agent
sapogenins Sapogenins: The aglucon moiety of a saponin molecule. It may be triterpenoid or steroid, usually spirostan, in nature.	1.96	1
glycolipids [no description available]	2.1	1
cucurbitane cucurbitane: structure in first source. cucurbitane : A triterpene that is an isomer of lanostane obtained by migration of the methyl group from 10 to the 9beta position.	2.31	1	triterpene
silybin Silybin: The major active component of silymarin flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum; it is used in the treatment of HEPATITIS; LIVER CIRRHOSIS; and CHEMICAL AND DRUG INDUCED LIVER INJURY, and has antineoplastic activity; silybins A and B are diastereomers.	7.25	1

Condition	Relationship Strength	Studies
Innate Inflammatory Response [description not available]	2.31	1
Experimental Lung Inflammation Inflammation of any part, segment or lobe, of the lung parenchyma.	2.76	2
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	7.31	1
Pneumonia Infection of the lung often accompanied by inflammation.	7.76	2
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.82	2
Encephalopathy, Toxic [description not available]	2.41	1
Idiopathic Parkinson Disease [description not available]	2.41	1
Parkinson Disease A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)	2.41	1
Polycystic Ovarian Syndrome [description not available]	2.41	1
Polycystic Ovary Syndrome A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; AMENORRHEA; ANOVULATION. Polycystic ovary syndrome is usually associated with bilateral enlarged ovaries studded with atretic follicles, not with cysts. The term, polycystic ovary, is misleading.	2.41	1
Cancer of Ovary [description not available]	2.41	1
Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.	2.41	1
Asthma, Bronchial [description not available]	2.21	1
Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).	7.21	1
Dementia Praecox [description not available]	2.25	1
Schizophrenia A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.	2.25	1
Diabetes Mellitus, Adult-Onset [description not available]	2.17	1
Diabetes Mellitus, Type 2 A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.	2.17	1
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	2.75	3
Fatty Liver, Nonalcoholic [description not available]	2.17	1
Obesity A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).	2.17	1
Non-alcoholic Fatty Liver Disease Fatty liver finding without excessive ALCOHOL CONSUMPTION.	2.17	1
Hyperglycemia, Postprandial Abnormally high BLOOD GLUCOSE level after a meal.	2.21	1
Cancer of Lung [description not available]	2.21	1
Metastase [description not available]	2.21	1
Hyperglycemia Abnormally high BLOOD GLUCOSE level.	7.21	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.21	1
Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	2.21	1
Lung Injury, Acute [description not available]	2.1	1
Acute Lung Injury A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).	7.1	1
Cancer of Skin [description not available]	2.01	1
Cocarcinogenesis The combination of two or more different factors in the production of cancer.	2.01	1
Skin Neoplasms Tumors or cancer of the SKIN.	2.01	1
Alloxan Diabetes [description not available]	2.03	1
Autoimmune Diabetes [description not available]	2.03	1
Diabetes Mellitus, Type 1 A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.	2.03	1

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