Page last updated: 2024-12-07

aspidin bb

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Aspidin BB is a natural product isolated from the fern Dryopteris filix-mas. It is a sesquiterpene lactone with a complex structure containing a cyclopentenone ring, a furan ring, and a cyclohexane ring. Aspidin BB has been shown to exhibit a range of biological activities, including anti-inflammatory, anti-cancer, and anti-malarial effects. Its anti-parasitic activity against tapeworms has been investigated for centuries, and it was historically used as a treatment for tapeworm infections. Aspidin BB is also being studied for its potential to inhibit the growth of cancer cells. Its mechanism of action is thought to involve inhibiting the production of certain enzymes that are important for cell growth and division. However, Aspidin BB is toxic to humans at high doses, and its use as a medication is limited due to these toxic effects. Further research is necessary to understand the potential therapeutic applications of Aspidin BB and to develop safe and effective formulations.'

Cross-References

ID SourceID
PubMed CID120290
CHEMBL ID4085355
CHEBI ID2883
SCHEMBL ID155672
SCHEMBL ID1649659
MeSH IDM0055691

Synonyms (25)

Synonym
brn 2068604
aspidin vv
2,5-cyclohexadien-1-one, 2-((2,6-dihydroxy-4-methoxy-3-methyl-5-(1-oxobutyl)phenyl)methyl)-3,5-dihydroxy-4,4-dimethyl-6-(1-oxobutyl)-
584-28-1
aspidin
aspidin bb
2-butanoyl-6-[(3-butanoyl-2,6-dihydroxy-4-methoxy-5-methyl-phenyl)methyl]-3,5-dihydroxy-4,4-dimethyl-cyclohexa-2,5-dien-1-one
2-butyryl-6-(3-butyryl-2,6-dihydroxy-4-methoxy-5-methylbenzyl)-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one
2-butanoyl-4-[(3-butanoyl-2,6-dihydroxy-4-methoxy-5-methylphenyl)methyl]-3,5-dihydroxy-6,6-dimethylcyclohexa-2,4-dien-1-one
unii-n21sd2r570
4-08-00-03749 (beilstein handbook reference)
n21sd2r570 ,
ccris 8458
2-((2,6-dihydroxy-4-methoxy-3-methyl-5-(1-oxobutyl)phenyl)methyl)-3,5-dihydroxy-4,4-dimethyl-6-(1-oxobutyl)-2,5-cyclohexadien-1-one
aspidin [mi]
3'-((5-butyryl-2,4-dihydroxy-3,3-dimethyl-6-oxo-1,4-cyclohexadien-1-yl)methyl)-2',4'-dihydroxy-6'-methoxy-5'-methylbutyrophenone
SCHEMBL155672
SCHEMBL1649659
CHEBI:2883
2-butanoyl-4-[(3-butanoyl-2,6-dihydroxy-4-methoxy-5-methyl-phenyl)methyl]-3,5-dihydroxy-6,6-dimethyl-cyclohexa-2,4-dien-1-one
Q27105862
DTXSID00973947
CHEMBL4085355
CS-0027463
HY-108164

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID1608393Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by MTT assay2019Bioorganic & medicinal chemistry, 09-01, Volume: 27, Issue:17
Natural product derived promising anti-MRSA drug leads: A review.
AID1608392Antimicrobial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by colony counting method2019Bioorganic & medicinal chemistry, 09-01, Volume: 27, Issue:17
Natural product derived promising anti-MRSA drug leads: A review.
AID1439492Antiparasitic activity against Schistosoma mansoni2017European journal of medicinal chemistry, Mar-31, Volume: 129Medicinal plants used as anthelmintics: Ethnomedical, pharmacological, and phytochemical studies.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (20.00)18.7374
1990's1 (10.00)18.2507
2000's0 (0.00)29.6817
2010's7 (70.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.82

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.82 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.21 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.82)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]